Abstract: The Anisakidae family nematodes are potentially zoonotic parasites; that infect a wide variety of aquatic species worldwide, with marine fish being the paratenic hosts. This family of eight genera could infest a wide variety of aquatic hosts during the development of their larval stages, mainly marine mammals, aquatic birds, such as pelicans, and freshwater fish, such crucian carp, these being the hosts where the life cycle is completed. These of clinical importance to human health are highlighted: Anisakis pegreffi, A. simplex sensu stricto, Contracaecum osculatum, Pseudoterranova azarazi, P. cattani, P. decipiens and P. krabbei. The geographical distribution of these genera and species is located mainly in the European continent, Asia, and South America, as well as in North and Central America and Australia. Its ability to adapt to the human organism has led to it being considered as a zoonotic agent. The disease in humans manifests nonspecifically, however the consumption of raw or semi-raw seafood is crucial information to link the presentation of the parasite with the disease. But what we need to know about the zoonosis, how do I know I have possible clinical presentation, and when I need to doubt if maybe I´m sick. We need to focus on knowledge education and clinical strategies.