{"id":4810,"date":"2023-07-12T07:12:54","date_gmt":"2023-07-12T07:12:54","guid":{"rendered":"https:\/\/mindspaceconferences.com\/neuroscience\/?post_type=program&p=4810"},"modified":"2023-07-12T07:12:54","modified_gmt":"2023-07-12T07:12:54","slug":"claudia-angeli","status":"publish","type":"program","link":"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/","title":{"rendered":"Claudia Angeli"},"content":{"rendered":"

Abstract<\/strong>
\nEmerging clinical data indicate that neuromodulation of the lumbosacral spinal cord restores motor and autonomic functions in those with chronic spinal cord injury. These discoveries provide evidence for the realistic potential of epidural stimulation to significantly improve function, health, and quality of life of those with chronic clinically incomplete and even complete spinal cord injury. To date, a major challenge related to the selection of stimulation parameters for promoting motor and autonomic function recovery in spinal cord injury individuals is that these parameters are task- and individual-specific. In addition, the combination of stimulation parameters potentially available is vast, as exemplified by the over 43 million different electrode configurations available when using a 16-electrode array. Our team relies on three components to guide tonic-interleaved functionally focused spinal cord epidural stimulation (scES). First, a neuroanatomical 3D spinal cord reconstruction model and intra-operative evoked potentials inform electrode lead placement. Second, spatial-temporal electrophysiological mapping informs motor and autonomic mapping. Lastly, task specific motor mapping and autonomic mapping will aid in identifying the tonic-interleaved functionally focused scES parameters. Immediate integrated movement and physiological responses to scES indicate the sophistication of the human lumbosacral spinal circuitry with the critical role for ongoing regulation of motor and autonomic function. We will present methods and tools for selection of task and individual configurations targeted for voluntary movement, standing, stepping, blood pressure stabilization and facilitation of bladder storage and emptying using tonic-interleaved excitation of the lumbosacral spinal cord. We will also present strategies used for selection of stimulation parameters for various motor and autonomic functions. Tonic-interleaved functionally focused neuromodulation targets a myriad of consequences from spinal cord injury with surgical implantation of the epidural electrode at a single location. This approach demonstrates the sophistication of the human spinal cord circuitry and important role in regulation of motor and autonomic functions in humans.
\nBiography<\/strong>
\nDr. Claudia Angeli is an Assistant Professor in the Department of Bioengineering at the J.B. Speed School of Engineering, and Director of the Epidural Stimulation Program at the Kentucky Spinal Cord Injury Center at the University of Louisville. She also holds an adjunct appointment at Frazier Rehab Institute, University of Louisville Health. Her research background and interests are focused in understanding mechanisms of control of human locomotion following neurologic injury. She has examined the impact of activity-based retraining of the nervous system following spinal cord injury. Currently, Dr. Angeli has been studying the use of spinal cord epidural stimulation combined with intense activity-based therapies for the restoration of function following motor complete spinal cord injury. Epidural stimulation uniquely targets recovery of movement patterns and augments functional gains through increase excitability of the spinal networks. The results of these studies contribute to the knowledge about the fundamental mechanisms of control of human locomotion and provide strategies for the rehabilitation of patients after neurologic injury. <\/p>\n","protected":false},"featured_media":4811,"template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_links_to":"","_links_to_target":""},"program_days":[33],"program_sessions":[58],"class_list":["post-4810","program","type-program","status-publish","has-post-thumbnail","hentry","program_days-day1","program_sessions-speakers"],"acf":[],"yoast_head":"\nClaudia Angeli - Neurology Conference<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Claudia Angeli - Neurology Conference\" \/>\n<meta property=\"og:description\" content=\"Abstract Emerging clinical data indicate that neuromodulation of the lumbosacral spinal cord restores motor and autonomic functions in those with chronic spinal cord injury. These discoveries provide evidence for the realistic potential of epidural stimulation to significantly improve function, health, and quality of life of those with chronic clinically incomplete and even complete spinal cord […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/\" \/>\n<meta property=\"og:site_name\" content=\"Neurology Conference\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindspaceconferences.com\/neuroscience\/wp-content\/uploads\/2023\/07\/Claudia-Angeli.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"210\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/\",\"url\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/\",\"name\":\"Claudia Angeli - Neurology Conference\",\"isPartOf\":{\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mindspaceconferences.com\/neuroscience\/wp-content\/uploads\/2023\/07\/Claudia-Angeli.jpg\",\"datePublished\":\"2023-07-12T07:12:54+00:00\",\"dateModified\":\"2023-07-12T07:12:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/#primaryimage\",\"url\":\"https:\/\/mindspaceconferences.com\/neuroscience\/wp-content\/uploads\/2023\/07\/Claudia-Angeli.jpg\",\"contentUrl\":\"https:\/\/mindspaceconferences.com\/neuroscience\/wp-content\/uploads\/2023\/07\/Claudia-Angeli.jpg\",\"width\":200,\"height\":210},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/mindspaceconferences.com\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"program\",\"item\":\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Claudia Angeli\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/mindspaceconferences.com\/neuroscience\/#website\",\"url\":\"https:\/\/mindspaceconferences.com\/neuroscience\/\",\"name\":\"Neurology Conference\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/mindspaceconferences.com\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Claudia Angeli - Neurology Conference","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindspaceconferences.com\/neuroscience\/program\/claudia-angeli\/","og_locale":"en_US","og_type":"article","og_title":"Claudia Angeli - Neurology Conference","og_description":"Abstract Emerging clinical data indicate that neuromodulation of the lumbosacral spinal cord restores motor and autonomic functions in those with chronic spinal cord injury. 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