{"id":5163,"date":"2024-05-23T04:14:37","date_gmt":"2024-05-23T04:14:37","guid":{"rendered":"https:\/\/mindspaceconferences.com\/neuroscience\/?post_type=program&p=5163"},"modified":"2025-06-11T12:22:02","modified_gmt":"2025-06-11T12:22:02","slug":"kenneth-b-storey","status":"publish","type":"program","link":"https:\/\/mindspaceconferences.com\/neuroscience\/program\/kenneth-b-storey\/","title":{"rendered":"Kenneth B. Storey"},"content":{"rendered":"

Abstract:<\/strong>
\nUnlike the brains of humans, animal brains are subject to extremes of environment \u2013 and must keep neural function intact during and after extreme conditions.\u00a0\u00a0 Frogs and turtles totally freeze in winter, displaying no measurable brain activity and a flat-lined heart. Hibernating ground squirrels have brains that survive weeks at 0oC. Mole rats survive deep hypoxia\/anoxia and maintain CNS function . \u00a0These states are termed \u201csuspended animation\u201d and are \u00a0characterized by global suppression of metabolic functions and the reprioritization of energy usage to essential survival processes . This extreme reorganization is elicited, in large part, by the regulatory controls of microRNAs. Our studies are \u00a0the first to investigate miRNA biogenesis and regulation in extreme \u00a0brains of vertebrates. \u00a0\u00a0\u00a0The studies are informed by the creation and analyses of miRNA \u201cOMES\u201d \u2013 complete RNA-seq studies \u00a0that have uncovered both up and down regulation of key microRNAs. These studies, coupled with quantitation of miRNA biogenesis factors, \u00a0illustrated an overall reduction in the majority of these processing proteins – \u00a0showing a potential suppression of miRNA maturation . Bioinformatic target enrichment of the \u00a0up-and-downregulated miRNAs of each extreme brain predicted their involvement in the potential activation of various neuroprotective processes such as synaptic signaling, intracellular signal transduction, and anoxia\/ischemia injury protection. The predominantly downregulated microRNA fingerprints identified in Nature, \u00a0suggests a microRNA-mediated cytoprotective mechanism responsible for maintaining neuronal functions and facilitating successful whole brain metabolic rate depression [ MRD].
\nBiography:
\n<\/strong>Ken Storey, PhD, FRSC, is a Professor of Biochemistry at Carleton University in Ottawa and holds the Canada Research Chair in Molecular Physiology. He graduated from University of Calgary (BSc 1971) and University of British Columbia (PhD 1974). Ken\u2019s field of interest is biochemical adaptation; in particular, mammalian hibernation and freeze tolerance are core topics in his over 1000 refereed publications. Ken won the 2010 Flavelle medal from the Royal Society\u00a0 of Canada , \u201cCryoFellow\u201d of the CryoBiology Society in 2012\u00a0 and the 2011 Fry medal from the Canadian Society of Zoologists.<\/p>\n","protected":false},"featured_media":5611,"template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_links_to":"","_links_to_target":""},"program_days":[32],"program_sessions":[58],"class_list":["post-5163","program","type-program","status-publish","has-post-thumbnail","hentry","program_days-day2","program_sessions-speakers"],"acf":[],"yoast_head":"\nKenneth B. Storey | Carleton University | Canada<\/title>\n<meta name=\"description\" content=\"Ken Storey, PhD, FRSC, is a Professor of Biochemistry at Carleton University in Ottawa and holds the Canada Research Chair in Molecular Physiology. He graduated from University of Calgary (BSc 1971) and University of British Columbia (PhD 1974). Ken\u2019s field of interest is biochemical adaptation; in particular, mammalian hibernation and freeze tolerance are core topics in his over 1000 refereed publications. Ken won the 2010 Flavelle medal from the Royal Society of Canada , \u201cCryoFellow\u201d of the CryoBiology Society in 2012 and the 2011 Fry medal from the Canadian Society of Zoologists.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindspaceconferences.com\/neuroscience\/program\/kenneth-b-storey\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kenneth B. Storey | Carleton University | Canada\" \/>\n<meta property=\"og:description\" content=\"Ken Storey, PhD, FRSC, is a Professor of Biochemistry at Carleton University in Ottawa and holds the Canada Research Chair in Molecular Physiology. 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