Scientific Sessions

Allergy and Clinical Immunology is a medical specialty that deals with the diagnosis and treatment of allergic and immunologic diseases. Allergies are abnormal reactions of the immune system to normally harmless substances, such as pollen, animal dander, and certain foods, which can cause symptoms such as sneezing, itching, and swelling. Clinical immunology, on the other hand, deals with the study of the immune system and its disorders, including autoimmune diseases, immunodeficiencies, and hypersensitivity reactions. Allergy and Clinical Immunology specialists use a range of diagnostic and treatment approaches, such as skin tests, blood tests, immunotherapy, and medication, to help patients manage their allergic and immunologic conditions.

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Clinical Management of Anaphylaxis refers to the medical care and treatment provided to individuals who experience severe and potentially life-threatening allergic reactions, known as anaphylaxis. Anaphylaxis is a serious allergic reaction that can affect multiple organ systems in the body and can be triggered by a variety of allergens, such as foods, medications, and insect venom. The clinical management of anaphylaxis involves rapid recognition of the signs and symptoms, prompt administration of epinephrine, and supportive care, such as oxygen therapy, intravenous fluids, and medications to treat symptoms such as itching, hives, and low blood pressure. Effective clinical management of anaphylaxis can prevent the progression of the reaction and improve the patient’s outcomes.

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Asthma management and control refer to the strategies and techniques used to prevent and alleviate the symptoms of asthma, a chronic respiratory disease characterized by inflammation and narrowing of the airways. The goal of asthma management and control is to minimize the frequency and severity of asthma attacks, improve lung function, and enhance the overall quality of life for people with asthma.

Asthma management involves several components, including identifying triggers that can cause asthma symptoms, such as allergens, pollution, or exercise, and avoiding them whenever possible. In addition, asthma management often involves the use of medications, such as bronchodilators or corticosteroids, to reduce inflammation and relax the airways. Education about proper inhaler technique and self-monitoring of symptoms are also important components of asthma management. Asthma control refers to the degree to which asthma symptoms are managed and kept under control. This can be assessed through monitoring of symptoms, lung function tests, and quality of life assessments. Achieving asthma control involves a collaborative approach between healthcare providers and patients, with regular follow-up appointments to adjust treatment plans as needed. With effective asthma management and control, people with asthma can lead active and healthy lives.

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Immunotoxicology is the study of immune system dysfunction that can occur as a result of occupational, accidental, or therapeutic exposure to a variety of chemical or biologic agents that affect human health and modify the immune system. Immunotoxicology can appear in a variety of ways, with immunosuppression being one of the most common. Immunotoxicology studies how medications and substances in the environment affect the immune system. Immune systems linked to a wide range of toxins are investigated. Immunotoxicologists study the immune-mediated effects of a variety of xenobiotics, including as pharmaceuticals, environmental pollutants, chemicals, and physical agents (i.e., UV light, radiation). In both experimental animal models and human investigations, efforts have been undertaken to investigate the links between laboratory markers of immune response and disease resistance. Immunotoxicology is primarily concerned with the identification of sensitive endpoints and the creation of experimental procedures to detect suspected immunotoxicants.

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The immune system is responsible for protecting the body against harmful pathogens such as bacteria, viruses, and fungi. Barrier surfaces such as the skin, gut, respiratory tract, and genitourinary tract play a critical role in preventing the entry of these pathogens into the body. The immunology of barrier surfaces involves the study of how the immune system interacts with these surfaces to prevent infections and maintain homeostasis.

The skin is the body’s first line of defense against pathogens and is equipped with a range of innate and adaptive immune cells that can quickly respond to invading pathogens. The gut and respiratory tract are lined with mucosal surfaces that contain specialized immune cells, such as T cells and B cells, that can recognize and neutralize pathogens. The genitourinary tract is also lined with mucosal surfaces that contain immune cells to protect against pathogens.

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Immunoassays are laboratory techniques used to measure the concentration of a particular analyte, such as a protein or hormone, in a biological sample. Immunoassays use the specific binding properties of an antibody or antigen to detect and quantify the target molecule. There are several different types of immunoassays, including enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), fluorescence immunoassays (FIAs), and chemiluminescent immunoassays (CLIAs), among others. Immunoassays are widely used in clinical laboratories and research settings to diagnose diseases, monitor treatment, and study biological processes.

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Immunoassays are laboratory techniques used to measure the concentration of a particular analyte, such as a protein or hormone, in a biological sample. Immunoassays use the specific binding properties of an antibody or antigen to detect and quantify the target molecule. There are several different types of immunoassays, including enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), fluorescence immunoassays (FIAs), and chemiluminescent immunoassays (CLIAs), among others. Immunoassays are widely used in clinical laboratories and research settings to diagnose diseases, monitor treatment, and study biological processes.

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Autoimmune disorders are a group of diseases where the body’s immune system mistakenly attacks its own healthy tissues, cells, and organs, instead of protecting them from foreign invaders like viruses and bacteria. Autoimmune disorders can affect various parts of the body, including the skin, joints, muscles, connective tissues, blood vessels, and organs such as the thyroid, pancreas, and kidneys.

Examples of autoimmune disorders include rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis, inflammatory bowel disease, and autoimmune hepatitis. The exact causes of autoimmune disorders are not fully understood, but genetics, environmental factors, and infections are believed to play a role. Treatment of autoimmune disorders typically involves suppressing the immune system to reduce inflammation and prevent further damage to tissues and organs.

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Immunotherapy for pediatric respiratory allergy is a treatment approach that uses the immune system to desensitize children who suffer from respiratory allergies, such as asthma, allergic rhinitis (hay fever), and allergic conjunctivitis. Immunotherapy, also known as allergy shots or sublingual immunotherapy, involves the administration of gradually increasing doses of the allergen to which the child is allergic. The goal of immunotherapy is to gradually desensitize the child’s immune system to the allergen, so that it no longer triggers an allergic reaction.

Immunotherapy for pediatric respiratory allergy can be particularly effective in children who do not respond well to traditional allergy medications or who experience side effects from these medications. The treatment is typically administered over a period of several months to several years, depending on the child’s response to the treatment. Immunotherapy has been shown to significantly reduce the severity and frequency of respiratory allergy symptoms in children, and can even lead to long-term remission of the allergy in some cases. However, immunotherapy does carry some risks, including the potential for allergic reactions to the treatment itself, and should only be administered under the supervision of a qualified healthcare professional.

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Food allergy and intolerance are two related but distinct conditions. Food allergy occurs when the immune system mistakenly identifies a harmless food protein as a threat and triggers an allergic reaction. Symptoms of food allergy can range from mild, such as hives and itching, to severe, such as anaphylaxis, a life-threatening allergic reaction that affects breathing and blood pressure. Common allergenic foods include peanuts, tree nuts, milk, eggs, fish, shellfish, wheat, and soy. On the other hand, food intolerance occurs when the body has difficulty digesting certain food components, such as lactose in dairy products or gluten in wheat products. The symptoms of food intolerance can be similar to those of food allergy, such as abdominal pain, bloating, and diarrhea, but are not caused by an immune system reaction.

Both food allergy and intolerance can have a significant impact on a person’s quality of life and require proper diagnosis and management. In the context of the Allergic Diseases sessions, the focus may be on the latest research and clinical practices related to the diagnosis, treatment, and prevention of food allergy and intolerance in various patient populations, including children and adults.

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Tumor immunology is the study of how the immune system interacts with cancer cells and tumors. The immune system has the ability to recognize and destroy abnormal cells, including cancer cells. However, cancer cells have developed various strategies to evade immune recognition and destruction. Tumor immunology aims to understand the underlying mechanisms of immune evasion by cancer cells and to develop immunotherapies that can boost the immune system’s ability to recognize and destroy cancer cells. Immunotherapies for cancer include treatments that target immune checkpoints, such as programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), as well as adoptive cell transfer therapies, such as chimeric antigen receptor (CAR) T-cell therapy. Tumor immunology research is also focused on identifying biomarkers that can predict response to immunotherapy and developing personalized treatment approaches based on the patient’s immune profile.

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The immune system is critical for protecting the body from infectious diseases and cancer. As we age, the immune system undergoes significant changes, which can have a significant impact on health and disease outcomes. The immune system is divided into two parts, the innate and adaptive immune systems. The innate immune system provides a rapid, non-specific response to pathogens, while the adaptive immune system is responsible for recognizing and responding to specific pathogens. One of the key changes that occur in the immune system with aging is immunosenescence, which is the gradual deterioration of immune function. This can result in a reduced response to pathogens, increased susceptibility to infections, and a reduced ability to mount an effective immune response to vaccines. In addition, the composition of immune cells changes with age, with a decrease in the number of naive T cells and an increase in memory T cells, which can lead to a reduced ability to respond to new infections.

Another change that occurs with aging is chronic inflammation, which is characterized by increased levels of pro-inflammatory cytokines and chemokines. This chronic inflammation can lead to tissue damage and is associated with many age-related diseases, such as cardiovascular disease, diabetes, and Alzheimer’s disease.

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Genetics and epigenetics play a crucial role in the development of allergic diseases. Allergic diseases such as asthma, eczema, allergic rhinitis, and food allergies have a significant genetic component, meaning they tend to run in families. Research has identified several genes that are associated with an increased risk of developing allergies. These genes are involved in the immune system and the body’s response to allergens.

Epigenetics refers to changes in gene expression that occur without changes to the underlying DNA sequence. Epigenetic modifications can be influenced by environmental factors, such as diet, pollutants, and stress. Epigenetic changes can alter gene expression in immune cells, leading to changes in the immune system’s response to allergens. Research in genetics and epigenetics of allergic diseases aims to identify specific genes and epigenetic modifications that contribute to the development of allergies. This knowledge can help researchers develop new therapies and treatments for allergic diseases. For example, understanding the genetics of asthma may lead to the development of personalized treatments based on an individual’s genetic makeup.

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Allergy prevention strategies refer to a set of measures that can be taken to prevent the development or reduce the severity of allergic diseases. These strategies can be broadly classified into primary prevention and secondary prevention.

Primary prevention aims to prevent the development of allergies in individuals who are not yet sensitized to allergens. This can be achieved through measures such as avoiding exposure to allergens, promoting a healthy lifestyle, and promoting exclusive breastfeeding in infants. Exposure to allergens can be reduced by avoiding environmental triggers such as pollen, dust mites, and animal dander, as well as by reducing exposure to food allergens in infants and young children.

Secondary prevention aims to reduce the severity of allergic reactions in individuals who are already sensitized to allergens. This can be achieved through measures such as allergen immunotherapy, which involves the administration of gradually increasing doses of allergens to desensitize the immune system and reduce the severity of allergic reactions. Other measures include the use of medications such as antihistamines, corticosteroids, and bronchodilators to control symptoms, as well as the use of emergency medications such as epinephrine to treat severe allergic reactions.

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Drug allergies and allergic rhinitis are two distinct types of allergic reactions.

Drug allergies occur when the immune system overreacts to a medication, resulting in symptoms such as rash, hives, swelling, or anaphylaxis. The symptoms can range from mild to severe, and may appear within minutes to hours after taking the medication. Allergic rhinitis, on the other hand, is a type of allergic reaction that affects the nasal passages. It is commonly known as hay fever and occurs when the immune system overreacts to allergens such as pollen, dust mites, or pet dander. The symptoms may include sneezing, runny nose, itchy eyes, and congestion.

Both drug allergies and allergic rhinitis can significantly impact a person’s quality of life and may require medical attention. Treatment options include avoiding the allergen, medications such as antihistamines and nasal sprays, and immunotherapy for allergic rhinitis. In the case of drug allergies, identifying the allergen and avoiding the medication is crucial, and in severe cases, emergency medical treatment may be required.

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Immunology research and therapies are focused on understanding and manipulating the immune system to treat various diseases. This field involves studying the mechanisms of immune response, including the identification and characterization of immune cells, signaling pathways, and immune-related genes. The goal is to develop immunotherapies that can modulate immune responses to treat diseases such as cancer, autoimmune disorders, and infectious diseases. Immunotherapy approaches include monoclonal antibodies, adoptive T-cell therapy, cancer vaccines, and gene therapy. The research in this field is rapidly evolving and has already led to the development of several successful immunotherapies.

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Computational immunology is an interdisciplinary field that combines immunology and computer science to study the immune system at a systems level. It involves the development and application of computational methods, algorithms, and models to analyze, simulate, and predict immune system behavior and its response to various stimuli, including pathogens, allergens, and drugs.

The main goal of computational immunology is to provide a comprehensive and quantitative understanding of the immune system’s complex and dynamic processes, such as immune cell activation, differentiation, migration, and interaction with other cells and molecules. This understanding can be used to design new drugs and therapies for immune-related diseases, such as cancer, autoimmune disorders, and infectious diseases. Computational immunology relies on various computational and mathematical techniques, such as machine learning, data mining, network analysis, and systems biology, to analyze large-scale experimental data from multiple sources, including genomics, proteomics, and metabolomics. These techniques can identify patterns and relationships within the data, and generate hypotheses that can be tested experimentally. One of the major applications of computational immunology is in vaccine design. Computational models can simulate the interaction between the immune system and the pathogen, and predict the most effective vaccine components and dosages to elicit a strong and specific immune response. This can greatly accelerate the vaccine development process and increase the success rate of clinical trials.

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Immunomodulation and immune regulation are the processes that the immune system uses to balance its response to pathogens and other foreign substances. The immune system is capable of recognizing and responding to a vast array of different antigens, but in some cases, the immune response can be too strong or too weak, leading to diseases such as autoimmune disorders or immunodeficiency.

Immunomodulation involves the use of agents or therapies to alter the immune response to achieve a better balance between a strong response to infection and preventing self-damage. Immune regulation is a natural process that helps the immune system maintain a state of equilibrium. It involves a range of different mechanisms, such as immune checkpoints and the production of regulatory T cells, to prevent an overactive immune response and protect against autoimmunity. Research in immunomodulation and immune regulation has led to the development of new therapies for a wide range of diseases, including cancer, autoimmune disorders, and infectious diseases. These therapies aim to enhance or suppress the immune response, depending on the specific disease and the needs of the patient.

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Immune development and aging refer to the study of how the immune system develops and changes over time, from birth to old age. It includes the investigation of how immune cells are produced and matured, how they respond to various stimuli, and how they change in number and function with age. The immune system plays a critical role in protecting the body from infections and diseases, but its efficacy decreases with age, leading to increased susceptibility to infections, autoimmunity, and cancer.

Understanding immune development and aging is crucial for the development of immunotherapies and vaccines that target specific age groups and for the treatment of age-related diseases that have an immune component. Research in this area has led to the discovery of new immune cells and pathways and has revealed the importance of the gut microbiome in regulating immune function.

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Allergy and hypersensitivity are conditions that result from an overactive immune response to a substance that is usually harmless. These substances, known as allergens, can include things like pollen, dust, certain foods, or medications. When the immune system overreacts to an allergen, it can cause symptoms such as itching, swelling, hives, or difficulty breathing.

In the context of immunology, the study of allergy and hypersensitivity focuses on understanding the mechanisms behind these immune reactions and developing strategies to prevent or treat them. This may involve investigating the cellular and molecular pathways involved in allergic responses, identifying new allergens, or developing immunotherapies to desensitize patients to certain allergens.

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Anaphylaxis is a severe and life-threatening allergic reaction that can be triggered by various allergens such as food, medications, and insect stings. Emergency management of anaphylaxis involves prompt recognition of symptoms and immediate administration of epinephrine, a medication that can reverse the severe symptoms of anaphylaxis and prevent further complications.

In this session, experts in the field of allergy and immunology will discuss the pathophysiology, diagnosis, and management of anaphylaxis. They will review the current guidelines for the emergency treatment of anaphylaxis, including the use of epinephrine auto-injectors, and provide practical tips for recognizing and managing anaphylactic reactions in different settings, such as schools, hospitals, and the community. The session will also address common misconceptions and myths surrounding anaphylaxis and provide up-to-date information on emerging therapies and future directions for research in this field.

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Immune pathology, researchers study the underlying mechanisms of immune-mediated diseases and their effects on different organs and tissues. This includes investigating the role of various immune cells, such as T cells, B cells, and natural killer cells, as well as cytokines and chemokines in the development and progression of diseases. By understanding the immune pathways involved in these diseases, researchers can develop new therapies to target these pathways and reduce disease severity.

Pharmacology is the study of drugs and their effects on the body. In the context of immune pathology, pharmacologists study the development and use of drugs that modulate the immune system. These include immunosuppressive drugs used to treat autoimmune diseases and prevent transplant rejection, as well as immunomodulatory drugs that enhance immune responses against cancer and infectious diseases. In summary, immune pathology and pharmacology are two interconnected fields that play a crucial role in the development of new treatments for immune-mediated diseases. Through a deeper understanding of immune pathways and the development of new drugs, researchers can improve patient outcomes and provide new hope for those affected by these diseases.

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Immunology of transplantation is a key area of study that deals with the immunological aspects of organ and tissue transplantation. When a person receives an organ or tissue transplant, the immune system of the recipient may recognize the transplanted tissue as foreign and mount an immune response against it. This immune response can lead to rejection of the transplant and failure of the transplant.

The sessions related to immunology of transplantation focus on understanding the mechanisms underlying transplant rejection and developing strategies to prevent it. Some of the key topics covered in these sessions include the role of T cells and antibodies in transplant rejection, the use of immunosuppressive drugs to prevent rejection, and the development of new therapies to promote transplant tolerance. Other important areas of study within immunology of transplantation include the use of stem cells for tissue engineering and regenerative medicine, as well as the ethical considerations surrounding organ donation and transplantation. Understanding the immunological mechanisms of transplantation is critical for improving the success rates of organ and tissue transplantation and improving the quality of life for transplant recipients.

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Environmental allergies refer to the allergic reactions caused by substances present in the environment such as pollen, mold, dust mites, pet dander, and certain foods. When an individual with an allergy comes into contact with an allergen, their immune system overreacts, causing symptoms such as sneezing, runny nose, itchy eyes, skin rash, and difficulty breathing.

Environmental allergies are quite common and affect a significant proportion of the population, particularly in developed countries. The prevalence of environmental allergies has been increasing over the years, which is thought to be due to factors such as urbanization, climate change, and air pollution. The management of environmental allergies involves identifying the specific allergen that triggers the reaction and implementing measures to avoid or reduce exposure to the allergen. Treatment options may include medications such as antihistamines, decongestants, and nasal corticosteroids, as well as immunotherapy or allergy shots, which can help desensitize the immune system to the allergen over time.

Prevention strategies for environmental allergies include keeping the indoor environment clean and free of allergens, avoiding exposure to pollen and other outdoor allergens during peak allergy seasons, and following a healthy lifestyle to support a strong immune system.

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Antigen research is a field of study that focuses on understanding the role and characteristics of antigens in the immune response. Antigens are substances that the immune system recognizes as foreign or non-self and triggers an immune response against them. These can be foreign pathogens such as bacteria, viruses, and parasites, as well as non-infectious substances like pollen, dust, or certain food proteins that can cause allergies.

Antigen research involves the identification and characterization of antigens, including their chemical and physical properties, molecular structure, and binding sites. This information is crucial for the development of diagnostic tools, vaccines, and immunotherapies that target specific antigens and modulate the immune response.

Antigen research also involves the study of the mechanisms that regulate the immune response to antigens, including the interaction between antigens and immune cells, such as T and B cells, cytokines, and chemokines. Understanding the complex interplay between antigens and the immune system is essential for the development of effective therapies for infectious diseases, cancer, autoimmune disorders, and allergies.

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Allergies are immune system reactions to substances that are typically harmless to most people. These substances, called allergens, can trigger a range of symptoms when they come into contact with the body. Common allergens include pollen, dust mites, pet dander, certain foods, insect stings, and certain medications.
Management and treatment of allergies depend on the type and severity of the allergy. Here are some key aspects of allergy management and treatment: Avoidance, Medications, Immunotherapy, Allergy Medications, Lifestyle Modifications, and Education.

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Allergic conjunctivitis is a common eye condition that occurs when the conjunctiva, the thin, transparent membrane covering the white part of the eye and the inner surface of the eyelids, becomes inflamed due to an allergic reaction. This condition is often triggered by exposure to allergens, such as pollen, dust mites, pet dander, or certain medications.
Hives, also known as urticaria, is a common skin condition characterized by raised, red, and itchy welts or bumps that can appear suddenly on the skin. These welts can vary in size and shape and often occur in clusters. Hives can be acute (lasting less than six weeks) or chronic (lasting longer than six weeks).

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T cell receptors (TCRs) and B cell receptors (BCRs) are two fundamental components of the immune system that play crucial roles in recognizing and responding to pathogens and foreign substances. They are essential for the adaptive immune response, which provides specific and targeted defense against infections. T cell receptors (TCRs) and B cell receptors (BCRs) are crucial components of the adaptive immune system. TCRs are found on the surface of T cells and recognize antigens presented by MHC molecules on infected or abnormal cells, while BCRs are found on the surface of B cells and can directly recognize antigens. Both receptors play pivotal roles in immune surveillance, pathogen recognition, and the generation of specific immune responses against infections and foreign substances.

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Psoriasis and Hashimoto’s thyroiditis are two distinct autoimmune conditions that can affect different parts of the body. Both psoriasis and Hashimoto’s thyroiditis are chronic conditions that require ongoing management. While they are distinct autoimmune diseases that primarily affect the skin (psoriasis) and the thyroid gland (Hashimoto’s thyroiditis), respectively, both conditions involve immune system dysfunction and may be influenced by genetic and environmental factors.

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Allergens and eczema, specifically atopic dermatitis, are closely related because eczema is often triggered or exacerbated by exposure to certain allergens. Allergens are substances that can trigger allergic reactions in individuals who are sensitive or allergic to them. Eczema, specifically atopic dermatitis, is a common chronic skin condition characterized by red, itchy, and inflamed patches of skin. It often occurs in individuals with a genetic predisposition to allergies or an overactive immune response.

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