Ophthalmic drug delivery focuses on administering medications directly to the eye to treat various ocular diseases and conditions such as glaucoma, infections, and macular degeneration. This specialized field aims to overcome the unique anatomical and physiological barriers of the eye, ensuring that therapeutic agents reach the targeted tissues in effective concentrations. Traditional methods include eye drops and ointments, which are easy to use but often suffer from poor bioavailability due to rapid tear turnover and limited corneal penetration. Advances in ophthalmic drug delivery have led to the development of innovative systems like sustained-release implants, nanoparticles, and in-situ forming gels, which provide prolonged drug release and improved therapeutic outcomes. These technologies aim to enhance patient adherence by reducing the frequency of administration and minimizing side effects. Moreover, targeted delivery systems, such as intravitreal injections and iontophoresis, enable direct delivery of drugs to the posterior segment of the eye, where many severe retinal diseases occur. The progress in ophthalmic drug delivery continues to improve the efficacy and safety of eye treatments, offering better management options for patients with ocular disorders.
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