Abstract

We will present an overview of our long-term team(s) experience during forty five years in the field of photodynamic therapy (PDT) of tumors by LASER, from drug discovery to clinical applications. The lecture main topics include: 1) Our search for ideal photosensitizers and discovery of uroporphyrin ability to be selectively retained in tumors for PDT and mechanism of action as well as cell biochemistry and function. 2) We will show our novel approach of biodistribution and selective in-vivo tumor localization of endogenous porphyrins induced and stimulated by 5-Aminolevulinic acid (ALA) as a newly developed technique which we adopted to treat certain types of cancers. 3) Removal of skin phototoxicity after PDT of tumors using our novel approach. 4) We will show PDT – clinical applications for treatment of certain types of cancers. 5) Recent therapeutic application of our ALA technique in combination with high energy photons as Radiodynamic therapy (RDT) of deep-seated tumors in lungs and brain. 6) We will present our future vision for ways to increase PDT efficacy and where do we go from here.

Biography

Professor Mohamed El-Far, worked in biochemistry field for 45 years, published over 120 peer reviewed papers. He received Fulbright and British council fellowships several times as well as German DAAD grant to establish PDT (photodynamic therapy of tumors by laser)program at Munich, also received US-AID grant to establish first PDT unit in Egypt , besides establishing first PDT unit in University of California, USA . He is serving on the editorial boards and Hon. Editor to four international journals. He acts as UNESCO expert in science and technology. Dr. El-Far served as visiting professor to University of California as well as Utah laser center also Mayo clinic for several years. He also served as a visiting professor to Cardiff and Swansea University, UK. He is a member of international photodynamic Association and Royal Society of Chemistry, UK. Selected and served as expert and consultant for biochemistry in the national committee of suprime council of University in Egypt, which is the highest nation honor. Recently selected as a member of higher Education and Research committee for Mansoura University. Selected by the International Biographical Center, Cambridge, England to be among top 100 scientists 2012. Received honary doctorate of letters from International Biographical Centre, Cambridge, England. Selected on list of global speakers as a keynote speaker and honorable guest as well as chairman for several international conferences in cancer as leading pioneer in cancer research and therapy and diabetes as pioneer in using phytochemicals with nanoformulation besides using subcutaneous transplantation of bone marrow dearived stem cells in macroencapsulation derived device for treating diabetes as pioneer approaches, as well as other recent biomedical applications as stem cells and nanotechnology.

Dr. El-Far is an international expert in photodynamic therapy (PDT) of tumors by laser; he is first worldwide to use sildenafil as novel antiabortive agent in recurrent spontaneous abortion. Dr. El-Far was selected as person of the year/ 2018 by Mansoura University, also selected by Royal Swedish Academy of Sciences to nominate Nobel prize winners in his field , for which is most prestigious honor in the world. In 2025 , he was selected as best scientist in Mansoura University in his field .