Abstract

Autoimmune disease is now recognized as one of the most pervasive chronic health challenges of the modern era, affecting an estimated 50 million Americans and growing globally. Despite this epidemic, most conventional approaches remain focused on symptom suppression rather than root-cause resolution. In this presentation, we examine a deeper and more integrative paradigm, the Gut-Autoimmune Axis, to uncover where inflammation truly begins, and how restoring gut and immune harmony can offer lasting healing.

This talk bridges the worlds of functional medicine and Ayurveda to present a unified theory of chronic disease progression and reversal. At the core of both traditions lies a foundational truth: digestion governs immunity. When gut integrity is compromised, whether through dysbiosis, food sensitivities, stress, environmental toxins, or suppressed digestive fire, both modern and ancient systems agree that systemic inflammation and immune dysregulation soon follow.

We explore the physiological mechanisms behind intestinal permeability (leaky gut) and its role in triggering autoimmune responses via immune overactivation, molecular mimicry, and loss of oral tolerance. This is then juxtaposed with the Ayurvedic concept of ama, a toxic metabolic residue formed from incomplete digestion, which similarly travels through the system, blocks bodily channels (shrotas), and gives rise to inflammation, fatigue, and disease.

Through clinical case examples and detailed treatment frameworks, Dr. Singh will demonstrate how the integration of functional lab testing, gut-repair protocols, Ayurvedic digestive strategies, herbal medicine, and nervous system regulation creates a multi-layered, high-impact roadmap for reversing chronic autoimmune presentations. Real-world outcomes, including symptom reduction, improved lab markers (zonulin, antibodies, microbiome), and enhanced quality of life, will be highlighted.

This presentation is ideal for practitioners, clinicians, and wellness professionals seeking to deepen their understanding of gut-autoimmune connections and develop truly integrative, systems-based approaches that go beyond pills, protocols, or symptom chasing.

REFERENCES:

• Fasano (2012). Leaky Gut and Autoimmunity. Clinical Reviews in Allergy & Immunology
• Rescigno (2017). Gut Barrier Function. Trends in Immunology
• Tripathi D. (2003). Essentials of Medical Pharmacology (Ayurveda)
• Tiwari (2009). Ayurveda: A Comprehensive Guide
• Kshirsagar , Nagpaul M. (2011). The Answer to Cancer

Biography

Dr. Bhavna Singh, ND, AP, is a Naturopathic Doctor and Ayurvedic Practitioner specializing in gut health, autoimmune healing, and functional lab integration. Through her signature Functional Ayurveda approach, she bridges ancient Ayurvedic wisdom with cutting-edge functional medicine to help clients uncover root causes, restore digestion, and rebalance the immune system. Dr. Singh’s clinical focus includes digestive disorders, hormone imbalance, and chronic inflammation. A sought-after speaker and educator, she empowers both patients and practitioners with practical, holistic tools to heal from the inside out, starting with the gut. She is the founder of the high-touch healing program Gut Revive.

Abstract

Traditionally viewed as detrimental to performance, mental fatigue and cognitive overload are increasingly being reinterpreted through the lens of adaptive neuroplasticity. In this presentation, I introduce a novel framework positioning cognitive load—especially in the form of deliberate mental fatigue induction through Brain Endurance Training (BET) as a potent catalyst for enhanced conscious experience, including access to flow states and mindfulness-like awareness. Drawing from neuroscience, sport psychology, contemplative science, and consciousness research, I synthesize findings that support a common neural pathway underpinning BET, mindfulness training, and the flow experience.

BET, originally designed to train cognitive resilience in athletes, involves prolonged response-inhibition tasks (e.g., Stroop, n-back) during or around physical training. Recent neuroimaging data show that BET increases structural-functional coupling in core executive and salience network regions—including the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and anterior insula—while concurrently downregulating activity in default mode network (DMN) regions such as the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). These changes reflect a brain reconfiguration similar to what is observed in mindfulness meditation and flow: increased task-positive network efficiency, reduced self-referential processing, and heightened interoceptive awareness.

Mindfulness training, especially in athletes, has shown to improve inhibitory control, decrease subjective mental demand, and foster attentional stability during high-load states. Neurobiologically, mindfulness is associated with enhanced engagement of the ACC and insula, supporting focused awareness and non-reactivity. Similarly, flow states are characterized by intense task immersion, diminished self-monitoring, and intrinsic reward, underpinned by a unique neural signature: activation of DLPFC, ACC, insula, and motor areas, with deactivation of the DMN, amygdala, and memory-related medial temporal lobe structures.

These converging findings suggest a shared tri-network dynamic: flow and meditative states arise when the salience network (ACC, insula) detects challenge and mobilizes the central executive network (DLPFC, parietal cortex) while suppressing DMN activity. BET appears to trigger this same reconfiguration through sustained cognitive challenge. The result is a state of high neural efficiency, low emotional reactivity, and deep task absorption—a flow-ready brain.

Importantly, both BET and mindfulness produce these changes without altering physiological markers of fatigue (e.g., heart rate, blood lactate, muscle metabolism), implying a central rather than peripheral adaptation. In this way, deliberate exposure to cognitive load combined with physical training may paradoxically reduce the felt cost of mental effort while enhancing focus and awareness. Such outcomes raise compelling questions: Can cognitive stress, when applied systematically, serve as a training vehicle for accessing altered states? Is flow an emergent property of optimized brain network dynamics?

By bridging high-performance training, contemplative neuroscience, and flow theory, this framework redefines the role of cognitive effort. It positions potentially BET not merely as a performance enhancer but as a consciousness-modifying tool; a cognitive pathway to the same states sought through meditation and spiritual practice. In doing so, it opens the door to future interdisciplinary research exploring how cognitive demand, far from being an obstacle, might be a gateway to expanded states of awareness.

Biography

Dr. Walter Staiano is a cognitive neuroscientist and performance psychophysiologist exploring how mental fatigue, mindfulness, and cognitive load affect both cognitive and physical performance, while also serving as gateways to flow and expanded consciousness. A pioneer in the study of mental fatigue and sport performance, he is also known for developing Brain Endurance Training (BET), a method that enhances both cognitive and physical resilience while altering brain network dynamics similarly to meditation. His work seeks to push the boundaries of human performance by bridging neuroscience, psychophysiology, and contemplative practice, offering a novel framework to rewire the mind towards heightened presence and awareness.

Abstract

In our modern quest for health, we often separate the mind, the body, and the spirit. Yet within every embodied being lies a subtle decoding system: one where emotional memory images (EMIs) serve as pre-conscious patterns linking experience, autonomic regulation and immune-inflammatory responses. Drawing on my model of Split-Second Unlearning (SSU), I propose that EMIs act as implicit ‘information networks’ that, when unintegrated, may provoke dys-coherence in the neuro-immune system and trigger neurogenic inflammation, pain sensitivity and chronic dysregulation.

In this keynote I will:

1. Outline how emotional memories (especially those rooted in adverse childhood experiences) embed themselves as high-fidelity prediction networks, driving autonomic and interoceptive responses outside conscious control.
2. Map how this information-driven dys-coherence can manifest in the immune system (via peptides such as CGRP), microglia, mast cells and macrophages – thus forging a bridge between emotional experience and inflammation.
3. Explore the concept of coherence as a pivotal therapeutic goal – including how ancient traditions (e.g., in Ayurveda, TCM, indigenous healing) already lift the mind-body membrane by restoring alignment between subtle pattern, physiology and environment.
4. Illustrate how the intervention method of SSU enables rapid recalibration of emotional-memory networks, enabling reconsolidation, restoration of heart-brain afferent rhythms, autonomic balance, and neuro-immune homeostasis.
5. Propose integration pathways for traditional and alternative medicine settings: how clinicians may apply coherence-based frameworks to support somatic, emotional and immunological healing.
6. Conclude with a call for research synergy: merging fractal theory, information-theory, extracorporeal memory models and traditional healing practices into a unified paradigm of “information drives inflammation (or its resolution)”.

If we succeed in re-framing emotional memory as information that literally regulates physiology, we open exciting avenues for synergy between cutting-edge neuroscience, trauma-informed therapy, and ancient holistic systems. My hope is that this keynote will not only illuminate a new therapeutic frontier but also invite practitioners of traditional medicine to consider how the invisible architecture of emotional memory may hold the key to resilient, coherent health.

Biography

For more than 25 years, Matt Hudson has dedicated his career to exploring the complexities of the human mind through disciplines such as neuroscience and quantum physics. His unique personal journey has equipped him with an exceptional ability to help individuals overcome mental and emotional challenges—often uncovering underlying issues that may go unnoticed by conventional practitioners. A pivotal moment in Matt’s life came after undergoing ear surgery. During his post-operative consultation, the surgeon expressed astonishment that Matt was able to speak at all, given the condition of his ears. This revelation led Matt to recognise that his ability to communicate did not rely primarily on auditory input. Instead, he had developed an extraordinary sensitivity to subtle, non-verbal cues—micro-movements in the hands, slight facial expressions, and other nuanced signals tied directly to human neurology. This deeper form of communication now forms the foundation of Matt’s work. By tuning into these micro-signals, he helps people access and resolve challenges at the neurological level, empowering them to achieve lasting change.

Abstract

Context: Medicinal and aromatic plants play a central role in the therapeutic, dietary, and cosmetic practices of local populations.Objectives: To highlight traditional knowledge and inventory the diversity of flora and associated ethnobotanical practices.

Methods: Between March 2024 and March 2025, an ethnobotanical survey was conducted among 406 inhabitants of the Fez-Meknes region. The information collected through semi-open interviews on medicinal, dietary, and cosmetic uses was used to calculate the family use value (FUV), the use value (UV), the value of the plant parts used (PPV), and the informant agreement index (IAR). A multiple correspondence analysis (MCA) was also conducted to explore the links between plant uses and the sociodemographic characteristics of the respondents.

Results: The study identified 123 species belonging to 55 botanical families. Lamiaceae dominated the flora studied (FUV = 0.154), while Ajuga iva had the highest use value (UV = 0.57). Maceration was the most common method of preparation (63.87%), and leaves were the most commonly used plant part (PPV = 0.78). Painful and inflammatory conditions were the most frequently reported therapeutic category (IAR = 0.96).

Conclusions: The results highlight the richness of local biodiversity and traditional knowledge, while emphasizing the need for further phytochemical and pharmacological research to scientifically support therapeutic, food, and cosmetic uses.

Keywords: Ethnobotany, medicinal and aromatic plants, Fez-Meknes, phytotherapy.

Biography

Meryem Doubi, third-year doctoral student at the Faculty of Sciences of Ibn Tofaïl University, Morocco, where shework at the Natural Resources and Sustainable Development Laboratory. Her research focuses on medicinal plants in the Fez region, their biological activities, and their therapeutic applications. She is also interested in secondary metabolites, their extraction methods, and phytochemical screening. As a recipient of the CNRST “PASS” scholarship, she involved in several research projects and aim to develop environmentally friendly solutions based on plant resources.

Abstract

Obesity, along with dyslipidemia and hyperglycemia, is a metabolic disorder growing in prevalence that is linked to chronic diseases such as atherosclerosis, hypertension, and type 2 diabetes. This study evaluated the anti-obesity, lipid-lowering, and anti-hyperglycemic effects of CB-02 capsules containing dry extracts of Phyllanthus emblica L., Dendrobium cate natum Lindl., and Gynostemma pentaphyllum in  HFD (High-fat diet)-induced obese Swiss albino mice. After 12 weeks of HFD induction, mice were treated orally with CB-02 (576 or 1152 mg/kg/day) for 8 weeks. CB-02 significantly reduced Body weight gain, Abdominal circumference, the Lee obesity index, and the relative weights of visceral fat and major organs. It also improved lipid profiles by decreasing  TC (Total cholesterol), TG (Triglyceride), LDL-C (Low-density lipoprotein cholesterol), and non-HDL-C (Non-high-density lipoprotein cholesterol), while increasing HDL-C (High-density lipoprotein cholesterol). These effects were comparable to orlistat (60 mg/kg/day). Furthermore, CB-02 lowered fasting glucose and improved insulin sensitivity, as indicated by an increased QUICKI (Quantitative insulin sensitivity check index) and HOMA-β (Homeostatic model assessment for β-cell function) and reduced HOMA-IR (Homeostatic model assessment for insulin resistance). Histopathological evaluation showed that CB-02 reduced hepatic steatosis and inflammatory cell infiltration and also attenuated β-cell morphological alter ations and pancreatic histopathological damage. These results suggest that CB-02 may be a promising therapeutic candidate for managing obesity and its comorbidities, including dyslipidemia, hyperglycemia, and hepatic steatosis, contributing to the prevention of type 2 diabetes and cardiovascular diseases in obese individuals.

Biography

Dr. Le Hong Phu is a lecturer, researcher, and Deputy Director serving as Head of the Cardiology–Nephrology–Rheumatology Department at the Vietnam Military Institute of Traditional Medicine, located at 442 Kim Giang, Dinh Cong, Hanoi. He earned his Ph.D. from the Shanghai University of Traditional Chinese Medicine in 2006, following a Master of Science degree from the Military Institute of Traditional Medicine in 2001 and a Bachelor of Science from the Vietnam Military Medical University in 1992. Since 2010, Dr. Phu has been deeply engaged in evaluating the pharmacological activities of herbal medicines, natural products, and traditional formulations, particularly in experimental models of metabolic, cardiovascular, renal, and inflammatory disorders. His work also includes assessing toxicity and safety profiles of natural compounds in experimental animals and conducting clinical evaluations of the efficacy and safety of traditional medicine–based therapies. His primary research focuses on the pharmacological and clinical evaluation of herbal medicines and traditional formulations for metabolic, cardiovascular, and renal diseases, and he has published four scientific papers indexed on Google Scholar.

Abstract

Obesity, along with dyslipidemia and hyperglycemia, is a metabolic disorder growing in prevalence that is linked to chronic diseases such as atherosclerosis, hypertension, and type 2 diabetes. This study evaluated the anti-obesity, lipid-lowering, and anti-hyperglycemic effects of CB-02 capsules containing dry extracts of Phyllanthus emblica L., Dendrobium cate natum Lindl., and Gynostemma pentaphyllum in  HFD (High-fat diet)-induced obese Swiss albino mice. After 12 weeks of HFD induction, mice were treated orally with CB-02 (576 or 1152 mg/kg/day) for 8 weeks. CB-02 significantly reduced Body weight gain, Abdominal circumference, the Lee obesity index, and the relative weights of visceral fat and major organs. It also improved lipid profiles by decreasing  TC (Total cholesterol), TG (Triglyceride), LDL-C (Low-density lipoprotein cholesterol), and non-HDL-C (Non-high-density lipoprotein cholesterol), while increasing HDL-C (High-density lipoprotein cholesterol). These effects were comparable to orlistat (60 mg/kg/day). Furthermore, CB-02 lowered fasting glucose and improved insulin sensitivity, as indicated by an increased QUICKI (Quantitative insulin sensitivity check index) and HOMA-β (Homeostatic model assessment for β-cell function) and reduced HOMA-IR (Homeostatic model assessment for insulin resistance). Histopathological evaluation showed that CB-02 reduced hepatic steatosis and inflammatory cell infiltration and also attenuated β-cell morphological alter ations and pancreatic histopathological damage. These results suggest that CB-02 may be a promising therapeutic candidate for managing obesity and its comorbidities, including dyslipidemia, hyperglycemia, and hepatic steatosis, contributing to the prevention of type 2 diabetes and cardiovascular diseases in obese individuals.

Biography

Nguyen Hoang Ngan is a lecturer and researcher at the Vietnam Military Medical University, where he currently serves as Head of the Department of Pharmacology at the Institute of Pharmacy Education. He earned his Ph.D. from Toyama University in Japan in 2014, following a Master of Science degree in 2005 and a Bachelor of Science degree in 1999, both from the Vietnam Military Medical University. His work focuses on evaluating the pharmacological properties and toxicity of drugs and natural products, including their antioxidant, anticancer, anti-inflammatory, anti-diabetic, wound-healing, and immune-boosting activities. He also conducts clinical assessments to determine the efficacy and safety of these substances. His research centers on the biological, pharmacological, and clinical effects of drugs and natural compounds, and he has published 21 scientific papers indexed on Google Scholar.

Abstract

Women of all ages, starting from puberty, often encounter challenges related to premenstrual syndrome (PMS) and menstrual symptoms. These challenges can include abdominal pain and psychological effects such as stress and anxiety, which can significantly impact brain function. Primary dysmenorrhea, characterised by painful menstrual cramps without identifiable pelvic pathology, affects a significant proportion of women of reproductive age, often impairing quality of life and daily functioning. Non-pharmacological interventions such as Yoga Asanas have been increasingly recognised for their potential to modulate pain perception and improve physiological balance. However, the neurophysiological mechanisms underlying these effects remain inadequately explored.

Objectives: This study aims to assess the therapeutic impact of selected Yoga Asanas on primary dysmenorrhea in young women by evaluating neurophysiological responses using electroencephalographic (EEG) recordings and applying deep learning techniques for pattern classification.
This interventional study was conducted young female engineering college students aged 18 to 25, lasting for six months. Participants were selected for the intervention group and the control group after obtaining informed consent. The intervention group underwent a supervised 24-week yoga program, focusing on five specific asanas designed to alleviate menstrual symptoms. This program was conducted five days a week, with each session lasting 40 minutes..EEG recordings were carried out during the 1st week, 12th week, and 24th week of the program using an 8-channel OpenBCI system for both groups. Power spectral density (PSD) analysis was performed for different frequency bands across various time bins in different brain lobes. A deep learning model was then employed to classify EEG patterns associated with pain intensity and relaxation states, enabling objective assessment of therapeutic outcomes. Participants’ subjective responses to the asana practice were also collected, and suitable statistical tests were performed as needed. The control group did not participate in any yoga practice.

Results: Power Spectral Density (PSD) analysis indicates an increase in alpha brainwave activity after six months of practicing yoga asanas. One of the deep learning techniques used, Bidirectional Long Short-Term Memory (BI-LSTM), demonstrated an impressive ability to accurately classify the signals as pain, normal, or yoga-related, achieving a high accuracy rate of 94.11%, which surpassed previous studies. Additionally, 91% of the participants reported a reduction in menstrual abdominal pain as well as associated psychological symptoms like anxiety and stress.

Conclusion: The integration of electroencephalographic evaluation with deep learning analysis provides an innovative framework to objectively quantify the therapeutic effects of Yoga Asanas in primary dysmenorrhea. This study’s findings indicate that yoga asanas can effectively reduce menstrual pain and enhance cognitive functions, as demonstrated through EEG PSD analysis and participant feedback. This suggests that yoga may serve as a viable alternative treatment for primary dysmenorrhea in young women.Further large-scale studies are warranted to validate these findings and refine predictive neuro-markers of therapeutic efficacy

Keywords: Dysmenorrhea, Yoga with asanas, Young Women, EEG, PSD, OPEN BCI, BI-LSTM

Biography

Dr. Anuradha has 20 years of Experience in Teaching, currently working as a Professor in the Department of Computer Science and Engineering at Sri Ramakrishna Engineering College. Have completed Ph.D. in the Research Area Data Mining (Fuzzy logic) and has a Master’s degree in Computer Science Engineering and a Bachelor’s degree in Computer Hardware and Software Engineering. SPOC of the Artificial Intelligence-Research Group and guided projects in the areas of Artificial Intelligence, Machine Learning, Cryptography and Data Analytics. Life member of ISTE, IEANG, & CSI and published Research papers in Scopus indexed Journals and Conferences. Awarded Silver Partner faculty under Inspire -The Campus Connect, Faculty Partnership Model, Infosys. Worked on consultancy projects with G.E Healthcare & LTTS (L&T technology) in the domain of medical image processing and deep learning. Convener of Artificial Intelligence Research Group at SREC and Lead person representing SREC at Leadingindia.ai, a nationwide initiative for artificial intelligence skilling and research-Bennett University, Noida. Worked on a TANSCST Funded project that involves Women Health with Brain Computer Interface and Yoga therapy.

Abstract

Women of all ages, starting from puberty, often encounter challenges related to premenstrual syndrome (PMS) and menstrual symptoms. These challenges can include abdominal pain and psychological effects such as stress and anxiety, which can significantly impact brain function. Primary dysmenorrhea, characterised by painful menstrual cramps without identifiable pelvic pathology, affects a significant proportion of women of reproductive age, often impairing quality of life and daily functioning. Non-pharmacological interventions such as Yoga Asanas have been increasingly recognised for their potential to modulate pain perception and improve physiological balance. However, the neurophysiological mechanisms underlying these effects remain inadequately explored.

Objectives: This study aims to assess the therapeutic impact of selected Yoga Asanas on primary dysmenorrhea in young women by evaluating neurophysiological responses using electroencephalographic (EEG) recordings and applying deep learning techniques for pattern classification.
This interventional study was conducted young female engineering college students aged 18 to 25, lasting for six months. Participants were selected for the intervention group and the control group after obtaining informed consent. The intervention group underwent a supervised 24-week yoga program, focusing on five specific asanas designed to alleviate menstrual symptoms. This program was conducted five days a week, with each session lasting 40 minutes..EEG recordings were carried out during the 1st week, 12th week, and 24th week of the program using an 8-channel OpenBCI system for both groups. Power spectral density (PSD) analysis was performed for different frequency bands across various time bins in different brain lobes. A deep learning model was then employed to classify EEG patterns associated with pain intensity and relaxation states, enabling objective assessment of therapeutic outcomes. Participants’ subjective responses to the asana practice were also collected, and suitable statistical tests were performed as needed. The control group did not participate in any yoga practice.

Results: Power Spectral Density (PSD) analysis indicates an increase in alpha brainwave activity after six months of practicing yoga asanas. One of the deep learning techniques used, Bidirectional Long Short-Term Memory (BI-LSTM), demonstrated an impressive ability to accurately classify the signals as pain, normal, or yoga-related, achieving a high accuracy rate of 94.11%, which surpassed previous studies. Additionally, 91% of the participants reported a reduction in menstrual abdominal pain as well as associated psychological symptoms like anxiety and stress.

Conclusion: The integration of electroencephalographic evaluation with deep learning analysis provides an innovative framework to objectively quantify the therapeutic effects of Yoga Asanas in primary dysmenorrhea. This study’s findings indicate that yoga asanas can effectively reduce menstrual pain and enhance cognitive functions, as demonstrated through EEG PSD analysis and participant feedback. This suggests that yoga may serve as a viable alternative treatment for primary dysmenorrhea in young women.Further large-scale studies are warranted to validate these findings and refine predictive neuro-markers of therapeutic efficacy

Keywords: Dysmenorrhea, Yoga with asanas, Young Women, EEG, PSD, OPEN BCI, BI-LSTM

Biography

Mrs. G. Rathi earned her Master of Engineering degree in Computer Science and Engineering from Anna University of Technology, Coimbatore, in 2012. She completed her Bachelor of Engineering degree in Computer Science and Engineering at Bannari Amman Institute of Technology, affiliated with Bharathiyar University, in 2002. With 18 years of teaching experience, her research interests encompass the Internet of Things (IoT), Cognitive and Computational Brain Science, and Business Intelligence. Currently, she is pursuing a Doctor of Philosophy degree at Anna University, Chennai. Mrs. Rathi has authored approximately 20 publications across various national and international journals and conferences. Awarded Silver Partner faculty under Inspire -The Campus Connect, Faculty Partnership Model, Infosys. Worked on consultancy projects with various industries. She holds lifetime membership in the Indian Society for Technical Education (ISTE) and the Computer Society of India (CSI), and is also a member of the International Association of Engineers (IAENG).Worked on a TANSCST Funded project that involves Women Health with Brain Computer Interface and Yoga therapy.

Abstract

Nutraceuticals are the substances that derived from food sources with additional health benefits in addition to the basic nutritional value. It is well known that many compounds of plant origin can ameliorate various patho-physiological conditions. Reactive Oxygen Species and free radicals are the key factors associated with oxidative stress that induce cell damage by interfering the biomolecules including DNA. Any molecule/s that can scavenge the free radicals have a potential to use as a nutraceutical.

While screening the nutraceutical potential of algae we could isolate two algae Asterarcys quadricellulare and Scenedesmus vacuolatus and found that it produced a variety of pigments. It was identified that A. quadricellulare produced b-carotene, astexanthin, lutein and canthaxanthin under nutrient limited cultural conditions. These pigments were subjected for bioassay and noticed that it possessed in vitro free radical scavenging property, cytotoxicity on HeLa and Ht29 cell lines as well as anti-inflammatory property on RAW 264.7 macrophage cell lines by inhibiting the action of inflammatory mediators like COX, LOX, MPO and iNOS and reducing cellular nitrite level. The aplanospores of S. vacuolatus accumulated canthaxanthin, b-carotene, astaxanthin and lutein under Nitrogen-limited conditions in a two-stage cultivation system. These pigments were subjected for bioassay and found that they possessed cytotoxic property on HeLa and HT-29 cell lines. These results indicated the nutraceutical potential of A. quadricellulare and S. vacuolatus.

Our laboratory also conducted diverse study on phytochemicals of plant origin. The plant one which we focused was C. papaya. A preliminary study of the flavonoids of this plant showed that it possessed a variety of nutraceutical potential. Hence, we standardized the methodology for isolating its flavonoid fractions from the leaf further fractionating with HPTLC, identifying flavonoids through UPLC-Q-ToF-MS/MS analysis, quantification by HPLC and evaluating free radical scavenging potential using DPPH and FRAP assays.

The Flavonoid rich fraction and HPTLC separated fractions were characterized via UPLC-Q-ToF-MS/MS analysis and identified 11 flavonoids with 4 new ones. HPLC quantification revealed that mauritianin is one of the major flavonoids in FFCP, with its yield being twofold higher compared to previous reports. Flavonoid rich fraction exhibited significant free radical scavenging and metal-reducing property. The antioxidant activity of the HPTLC fractions of FFCP showed that the quercetin and its derivative-containing fraction (B3) exhibited superior antioxidant activity compared to the fraction containing kaempferol and its derivatives.

The in-vitro investigation demonstrated that the flavonoid fraction of exerts cytoprotective effects on human erythrocytes and peripheral blood mononuclear cells (PBMCs). It was ascertained by SEM, H2O2 induced oxidative damages such as lipid peroxidation, LDH leakage, DNA damages, effectively reduced intracellular ROS production and calcium mobilization. The efficacy was ascertained by increased the activity of antioxidant enzymes, upregulated Nrf2 gene expression and its nuclear translocation. ADMET and drug likeness prediction showed that all flavonoids have good ADME and drug likeness score to develop as a potential drug against oxidative stress associated diseases. Flavonoid rich fraction inhibited the activity of key inflammatory enzymes namely COX, LOX, and iNOS responsible for the production of proinflammatory markers such as prostaglandins, leukotrienes, and nitric oxide. Additionally, the fraction downregulated the expression of the NF-κB transcription factor and the subsequent production of pro-inflammatory markers such as TNF-α, IL-6, and IL-1β in LPS induced cells.
These studies revealing the potential of algal pigments obtained from two algae and flavonoids of plant origin have nutraceutical value to ameliorate the consequences of free radical medicated damages.

Biography

Prof. Krishnakumar. K, PhD in Biochemistry, currently working as a Professor in Department of Botany, Maharaja’s College, supervising research students in the field of nutraceuticals, published more than 25 research articles in the field of nutraceuticals, presented papers in national and international seminars, 25 years of teaching Botany.

Abstract

Autoimmune diseases, characterized by the immune system’s erroneous attack on the body’s own cells, present a complex pathophysiological challenge, often necessitating a comprehensive and integrative treatment strategy. The current emerging complementary therapies, such as Siddha and energy healing, offer a holistic approach to restoring immune balance by addressing both the underlying causes and symptomatic manifestations of autoimmune disorders. Crohn’s disease (CD), a chronic autoimmune disorder affecting the gastrointestinal tract, is characterized by inflammation, abdominal pain, diarrhea, weight loss, and malabsorption. Conventional treatments involve immunosuppressants, biologics, and surgery, but chances for relapse of the system are always present. Many patients seek complementary therapies to manage symptoms and improve quality of life in such conditions.

According to Siddha principles, Crohn’s is caused by an imbalance in the three humors (Vatham, Pitham, and Kapham), primarily Pitha aggravation, leading to chronic intestinal inflammation. Traditional Siddha medicine offers a holistic and integrative approach in managing Crohn’s disease, focusing on restoring immune balance, reducing inflammation, and healing the gut. This study presents two cases of Crohn’s disease successfully managed at Chakrasiddh, demonstrating significant clinical improvement through Siddha-based therapy, energy healing, and dietary modifications. Both cases exhibited marked improvements in laboratory biomarkers, symptomatic relief, and colonoscopic findings following treatment. Pre and post-therapy assessments, including biochemical parameters, inflammatory markers, and endoscopic evaluations, provide objective evidence of the therapeutic efficacy of this integrative approach. These findings highlight the potential role of Siddha therapies in complementing conventional treatments for autoimmune gastrointestinal disorders like Crohn’s disease, promoting both symptomatic relief and mucosal healing.

Biography

Dr. Sathya Sindhuja, a renowned 36th-generation Siddha healing practitioner, brings over 35 years of expertise in holistic wellness, having successfully treated nearly 100,000 patients worldwide. As the Founder and Director of Chakrasiddh Holistic Centre, she seamlessly integrates Siddha therapies with customized energy healing sessions, fostering profound remedials and balance. Recognized as a divine healer and esteemed astrologer, Dr. Sindhuja possesses the unique ability to read auras, offering insights into both past influences and future well-being. Her exceptional healing practices have garnered international recognition, attracting patients from around the globe. A dedicated philanthropist, she extends free treatments to the underprivileged, exemplifying her unwavering commitment to public welfare and holistic care. She has also served distinguished dignitaries, Telugu celebrities, and prominent personalities, earning widespread admiration. With a specialized focus on women’s health, mind-body interactions, and dietary wellness, Dr. Sindhuja has contributed extensively to the academic and medical communities, authoring 30 peer-reviewed articles and delivering numerous public lectures. Her contributions have been honored with prestigious accolades, including the Times Group’s Icon in Siddha Vaidyam Award and the Dr. A.P.J. Abdul Kalam Award for Ancient Siddha Therapy. Through her compassionate care, groundbreaking research, and holistic healing approach, Dr. Sathya Sindhuja continues to pioneer the global advancement of Siddha medicine, transforming lives and shaping the future of integrative healthcare.

Abstract

India is fast becoming an active hub neutraceuticals and is poised to take off to a higher trajectory of growth potential by 2030 reach to a 100 billion dollar industry* from the current growth rate of over 26 percent. It was during the Covid 19 pandemic the growth stabilized from 10 percent to over 16 percent and the shift is still positive. The holistic change was admittedly due to an increase in the wide number of Indians consuming basic nutraceuticals during the pandemic. It was during the pandemic period the Indian community woke up to fuel the growth and touch the present growth from an early meager rate of around ten percent.
It is a fact that the medicinal farming sector is vibrant in its 52 Agro-climatic zones with about 1700 medicinal plants and with the aid of IT applications, the environment is acting as a driving force for raw material supply chain for nutraceutical products. Besides, India has become a focus of vast number of world-class GMP facilities in the Formulation ecosystem and could proudly be termed as having the largest FDA-approved contract manufacturing facilities in the world with additional high-end nutraceutical manufacturing facilities. In fact, India has become a global contract manufacturing hub in nutraceuticals. Further, it is stated that the Start-up ecosystem in India is having around 7500 nutraceutical start-ups embracing latest technological transformation taking place across the entire ecosystem.
——————————-
*Survey Conducted by Nutrify Today*
One of the major issues that were currently faced was a lack of awareness among the consumers. The differentiated responsible nutraceutical portfolios need to be drawn up along with clinical validation outcomes. At the current pace and trend, India is likely to offer wealth of opportunities for the nutraceutical industry outside the USA.
From 2021 onwards, Immune health has become synonymous with maintaining a healthy lifestyle. However, except few products related to Black Pepper, Turmeric, Ginger, Fenugreek, Saffron, Pomegranate and few others, there has been a lack of innovation within the Immune Health category. In the wake of a turbulent Covid 2020, consumers are more focused on taking care of their health and are looking for safe, transparent, quality solutions focusing mainly to botanical and herbal solutions.
The emergence of nanotechnology has also changed the face of the booming nutraceuticals in India as well. New technologies like water dispersion technology, The use of Polar-Non-polar Sandwich (PNS) technology, The Hydroalcoholic extraction have also changed the face of nutraceutical industry in India.
New horizons that will contribute to advanced research in the field of Spices primarily leading to have detox potential, strategic nutrition for organ health and holistic health solutions have to be focused upon, including well designed Clinical Studies on a pharma level.

Biography

Dr. M P Suresh is a multi-disciplinary academic post-graduate and Doctoral Degree holder from World-class Madras University, across his career in Spices Board of India, he has handled myriad roles as Editor and Deputy Marketing Director and gained insightful experience in Marketing, Export Promotion, New Product Development, Quality and Safety of spices and spice products spanning over three decades. He gained hands on experience in policy formulation related to marketing, export promotion and export development including market access initiative projects in overseas markets, up-gradation of technology, and organised several National and International Seminars and Buyer-seller meets of Spices Board. Besides a Master trainer and Resource Person for various programmes on marketing and post-harvest improvement of spices, he presented several Papers in National and International Conference, Seminars and Workshops. He had also officiated as Chief Rapporteur in International Conferences including that organised by FAO and WHO.
Suresh has gained rich cross-cultural experience from his travel to Saudi Arabia, Malaysia, Singapore, USA, Brazil, China, Tokyo, UAE and Bahrain.
He has been teaching at prestigious universities like IGNOU, Government of India and Pondicherry University as a Senior Guest Faulty over the last 35 years in multi-disciplinary subjects at Bachelor and Master Level and as a media personnel, he did programmes over Television and also covered national and international events for print media with credit for over 300 articles in leading English publications on a variety of topics. He is a recipient of Fellowship of UNDP.

Abstract

Aedes aegypti (Linnaeus, 1762) is one of the most medically important mosquitoes because it is a vector of different arboviruses in urban areas, such as dengue, chikungunya and zika. The use of synthetic topical repellent based on N,N-diethyl-3-methylbenzamide (DEET) is one of the main methods of protection against the vector. However, studies show that mosquitoes have been showing resistance to the repellent action of DEET, which demonstrates the importance of alternative topical repellents, such as those based on essential oils (EOs). Among plant species that synthesize EOs is Croton sp. In this sense, the objective was to evaluate the in vitro topical repellent activity of the EO from Croton sp leaves against Ae. aegypti. For the test, mated female mosquitoes up to ten days old were used. Firstly, we sought to estimate two effective concentrations to repel 50 and 99% of mosquitoes from concentrations of 125; 100; 75; 50 and 25 mg/cm2 formulated in non-ionic emulsion. Each concentration was evaluated as follows: with 50 mosquitoes in the cage, five areas of 4.9 cm2 were marked on the upper part. A quantity of 0.1 g of the formulation initially containing the lowest concentration was applied to one of the markings. Subsequently, an artificial feeder containing 1 mL of blood from Capra aegagrus hircus (Linnaeus, 1758) preheated to 37 °C was placed over each concentration for three minutes (For the use of blood, the project was approved under registration 23076.058811/2020). The evaluation criterion was the number of landings. Next, the protection time of the 99% effective repellent concentration was evaluated. The same materials described above were used for the test. However, the evaluations were as follows: After 30 minutes of applying the 99% effective concentration, the artificial feeder was placed over the concentration for three minutes. Afterwards, the feeder was removed and placed in a water bath until the next evaluation, which occurred at 30-minute intervals, until 360 minutes were completed. The evaluation criteria were landings and blood feeding. The results showed that to repel 50 and 99% of mosquitoes, the estimated concentrations were 3 and 109 mg/cm2, respectively. The concentration of 109 mg/cm2 offered 64.8% protection against landings in 360 minutes and 100% against blood feeding for 150 minutes. The results indicate that Croton sp leaf EO is a promising alternative topical repellent in protection against the mosquito Ae. aegypti.

Biography

Prof. Janaina Freitas holds a degree in Biological Sciences (Licentiate and Bachelor’s) from the State University of Paraíba (UEPB, 2003) and a Ph.D. in Biochemistry from the Ribeirão Preto Medical School – University of São Paulo (FMRP-USP, 2008). Currently is a Full Professor at the State University of Southwest Bahia (UESB), teaching in the Chemistry, Environmental Engineering, Food Engineering, Animal Science, and Biological Sciences programs.

Currently is a permanent member of the Graduate Program in Environmental Sciences (PPGCA) and serves as the Local Coordinator of the Multicenter Program in Biochemistry and Molecular Biology (PMBqBM). Her research focuses on microbial metabolism and genetics, as well as biotechnology, particularly in fermentation processes for bioproduct production. She collaborates with the Innovation and Biotechnology Laboratory (InBiotec).

Abstract

SKY is increasingly gaining recognition as a means to relieve occupational stress and burnout especially in high-stress environments. The controlled breathing patterns of SKY are meant to bring about the relaxing effect, emotional regulation, and general improvement in employees’ mental well-being.
Research has shown that SKY can significantly reduce the levels of stress and elevate psychological well-being among professionals. For example, a randomized control trial with medical doctors showed a significant decrease in psychological distress and burnout among participants participating in a SKY program against those who just received standard training on stress management (Korkmaz, 2024). This is specifically relevant because doctors and other professionals in the healthcare line experience high rates of stress and burnout and this can worsen their effectiveness and well-being (Korkmaz, 2024). The study demonstrates the viability of applying SKY as a non-pharmacological intervention in boosting resilience and coping in high-stress occupations.
Additionally, the physiological aspects of SKY contribute to its effectiveness in handling workplace stress. The exercise is known to enhance vagal tone, associated with improved emotional regulation and decreased reactivity to stress (Parimala & Kanchibhotla, 2020; Goldstein et al., 2016). This physiological response is essential for individuals working in stressful work environments, as it may result in effective stress management and reduced anxiety levels (Parimala & Kanchibhotla, 2020). SKY has also been associated with enhanced cognitive functioning and attention, which are necessary for keeping one’s productivity and concentration in the workplace (Chandra et al., 2016; Kopańska et al., 2022).
Besides these, the effectiveness of SKY in reducing burnout is complemented by the fact that it instills a feeling of community and social support in practitioners. Practice in group sessions of SKY can enhance the sense of social connection, a protective factor for burnout, as indicated by Vasudev et al. (2022). This sense of community provides both emotional support and stimulates the sharing of coping strategies at work, therefore creating a work environment that fosters support.
There is a potential positive effect of integrating SKY into workplace wellness programs. Organizations that adopt SKY as part of their employee wellness initiatives have reported improvement in employee satisfaction, reduced absenteeism, and overall workplace morale (Bhaskar et al., 2020). These outcomes suggest the potential for SKY as a holistic approach to managing workplace stress and preventing burnout.
In conclusion, Sudarshan Kriya Yoga offers a multifaceted approach to addressing workplace stress and burnout. Its effectiveness in reducing psychological distress, enhancing emotional regulation, and fostering social support makes it a valuable intervention for individuals in high-stress occupations. Continued research and implementation of SKY in workplace settings could provide significant benefits for employee well-being and organizational health.

Biography

Dr. Monika Pathania is an accomplished medical professional serving as an Additional Professor in the Department of Medicine at the All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand. She has also held key administrative roles as Ex-Associate Dean (Research) and Ex-Assistant Dean (Student Welfare) at the institute. With a distinguished academic background, including an MD in Internal Medicine and certifications in Lifestyle Medicine (IBLM, ASLM, ISLM), Dr. Pathania has significantly contributed to healthcare innovation. She pioneered the institute’s first “Lifestyle Disease Clinic” and later expanded it into an Integrative Medicine Clinic and a Professional Burnout and Well-Being Clinic. Her research portfolio includes 112 publications and 18 projects. She is a DFID fellow in diabetes from CMC Vellore and a board-certified lifestyle medicine physician. Additionally, she is a certified yoga instructor under AYUSH (200 hours) and SSY. Dr. Pathania’s excellence has been recognized with several prestigious awards, including the Outstanding Woman Researcher in Internal Medicine Award (VIWA 2024), Excellence in Research of the Year Award (DISTF-2023), and Best Teacher Award (2018). She has also received accolades for her presentations at national conferences and achievements in yoga competitions.

Abstract

Anuloma Viloma Pranayama (AVP), also known as Alternate Nostril Breathing (ANB), is a widely practiced pranayama technique known for its regulatory effects on cardiovascular and brain activity. This study aimed to explore the simultaneous effects of AVP on heart rate variability (HRV) and brain wave activity in a cohort of 30 healthy volunteers practicing kriya yoga for over 15 years. The study was conducted from October to December 2021. ECG for HRV analysis and EEG recordings for brain wave spectrum analysis were collected during three phases: pre-AVP, during AVP, and post-AVP, each lasting five minutes.
Statistical analysis using repeated measures of analysis of variance (ANOVA) with Bonferroni and Holm’s post-hoc comparisons showed significant increases in time-domain HRV parameters (SDNN and RMSSD) during AVP compared to pre- and post-AVP. In frequency-domain analysis, total power, LF power, HF power, and LF/HF ratio also showed significant increases during AVP, with the LF/HF ratio remaining elevated post-AVP. EEG recordings revealed a significant rise in Alpha, Beta, and Gamma wave power during AVP compared to baseline and post-AVP phases. These findings suggest that the lungs, heart, and brain act as coupled oscillators, and AVP induces an aroused, attentive state without significantly affecting heart rate, while enhancing overall HRV.

Biography

Dr. Varun, MD, DNB, MNAMS, holds a diploma in Naturopathy and Yoga and has been a regular faculty member at several institutions. He previously served as a Professor and Head of the Department at Santosh Medical College and is currently an Additional Professor in the Department of Physiology at AIIMS Bhopal. With 22 years of experience, his research interests include Medical Education and Mind-Body Medicine. Dr. Varun conducts yoga and meditation sessions for students and staff and enjoys sharing his passion for physiology. He has received multiple awards, including the prestigious Shri Ram Murthy, VIHA, and ISSN awards.

Abstract

Unrelenting neuropathic pain presents challenges in diagnoses and treatment. The International Association for the Study of Pain (IASP) defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system.” The injury or disease may occur in the peripheral or central nervous system giving rise to painful conditions such as post herpetic neuralgia, painful diabetic neuropathy, post amputation pain, complex regional pain syndrome, trigeminal neuralgia, post stroke pain, and pain after spinal cord injury, to name a few. These patients are frequently disabled from severe pain, have poor quality of life, and suffer from anxiety, depression and sleep problems. They often strain the healthcare system with frequent visits. Treatment of neuropathic pain can be challenging, often exhausting conventional approaches. A multimodal approach integrating pharmacological, interventional and integrative modalities may be helpful. This talk will cover a brief review on the pathophysiology of pain and focus on interventions that specifically target neuropathic pain, such as neuromodulation, including peripheral nerve stimulation and infusions using ketamine.

Biography

Dr. Chin is Professor Emeritus of Anesthesiology and Critical Care Medicine at the George Washington (GW) University, Washington DC. She served as Director of the GW Pain Medicine Fellowship Program and Co Director of the GW Spine and Pain Center. Dr. Chin earned her medical degree at the University of Melbourne, Australia. Her interests include innovative pharmacological, interventional and neuromodulatory techniques for management of chronic neuropathic pain. She has published on topics in pain medicine including pain in women, written numerous articles and authored book chapters on both acute and chronic pain. She served on the American Society of Anesthesiologists (ASA) Pain Medicine Committee, the American Medical Association (AMA) advisory board for pain, the Anesthesia and Analgesia (A&A) Editorial board as a reviewer, and the American Board of Anesthesiologists (ABA) as an associate board examiner. She has presented and lectured on acute and chronic pain at national meetings including the ASA, the American Society of Regional Anesthesia and Pain Medicine and the American Academy of Pain Medicine. For the past twenty years she was consistently listed in Washington Top Docs for Pain Medicine and was recently awarded the Trailblazer Award from ASRA.