Abstract

Bacterial infections are the most prevalent diseases affecting fish, often internal but sometimes external. During the survey, 13 out of 28 bacterial isolates were selected for further screening. Based on hemolysis, AR2 (Providencia rettgeri) was selected for further experimental study and found to be pathogenic in H. fossilis. Based on agar diffusion test, Withania somnifera was found most effective among herbal plants, whereas Eisenia fetida was found most effective among different earthworms. P. rettgeri is a Gram-negative, opportunistic bacterium. This study describes the isolation of the pathogenic bacterium P. rettgeri AR2HAU from diseased Heteropneustes fossilis. To our knowledge, this bacterium is the first report of a pathogenic bacterium from H. fossilis. This pathogenic bacterium was experimentally injected into healthy fish to confirm its pathogenicity. The experimentally induced infection resulted in skin darkening, accumulation of body fluids, and redness around the mouth and anal region. Histopathological examination of the intestines from experimentally infected fish revealed mild infiltration of mononuclear cells—mainly lymphocytes—within the mucosa, along with goblet cell hyperplasia.

Biography

Prof. R.K. Gupta, presently working as Head of Department Zoology, CCS Haryana Agricultural University is a Professor of zoology since 2009. Dr. Gupta did his graduation from Kurukshetra University, Kurukshetra. Post graduation and Doctorate from CCS Haryana Agricultural University. Dr. Gupta has completed many nationally funded projects on various aspects like, sustainability, conservation strategy of fisheries, water management and fish pathology. He was also associated with Academy of Environmental Biology, Lucknow and Indian Society of Life Sciences, Kanpur. He worked in different positions in Haryana Agricultural University. He guided 16 M.Sc and 8 PhD students. He is reviewer of many Journals. He authored 17 books/manual, 102 research papers in Journals of national and international repute, 10 book chapters, 57 poplar articles and presented more than 50 papers in national and international seminars/symposia and conferences. He has organized various training programmes for farmers and officers of the state department to disseminate the technology regarding agroforestry. He is associated with many professional societies as member/life member or executive member.

Abstract

Objectives: The prevalence of breast cancer is increased globally, there is need of promising drugs without side effects. So, we can design drugs against various breast cancer targets like ER, HER-2, CDK 4, PARP etc. 9-anilinoacridines play an important role as antitumor DNA-intercalating agents, due to their antiproliferative properties. Several anticancer agents with 9-anilinoacridines such as amascrine and nitracrine have been developed. But these drugs have some adverse effects

Methods: In the present study, for identification of potential ligands of 9-anilinoacridines as selective ERα inhibitors (2IOG.pdb) targeting breast cancer by using Schrodinger suit-2025-2, Maestro 14 version. In-silico design was performed using Schrodinger suite 2024-2. Thiazine substituted 9-anilino acridines were designed and docking studies were performed in Glide Module against ERα (2IOG.pdb) targeting breast cancer. ADMET studies were performed in Qikprop module, Binding free energy calculations by Prime-MMGBSA module and MD simulation study was done in Desmond module to check the behaviour of docking complex in our body environment. Based on in-silico results, the selective thiazine substituted 9-anilino acridines (7a-j) are synthesized by given scheme and the compounds are Characterized and confirmed by ¹H NMR, ¹³C NMR, IR, Mass spectra. Evaluation of In-vitro anti-breast cancer activity against MCF-7 cell by MTT assay, ER binding assay and gene expression are performed. The In vivo efficacy of compound was assessed using an MCF-7 xenograft mouse model

Results: The 9-anilinoacridine derivatives 4a-j have good binding affinity with Glide score in the range of –8.11 to -12.64  Kcal/mol when compared with the standard Nitracrine (-5.61) and tamoxifen (-7.81). The ADMET screening of the designed molecules are within the recommended values. MM-GBSA binding results of most potent inhibitor displayed stable and favorable.  A 100ns MD simulation study also confirms the stability of docking complex. The compounds with good Glide scores are synthesized, characterized and evaluation of Anti-breast Cancer activity against MCF-7 Cell lines also performed Two of the synthesized compounds 4f & 4j had shown good IC₅₀ values 123.3µM and 164µM. ER binding assay and gene expression by RT-PCR method had also proven that these compounds are good antagonist to estrogen receptor.

Conclusion: The results reveal that, this study provides evidence for consideration of valuable ligands in 9-anilinoacridine derivatives as potential ERα inhibitor and the compounds, 4f & 4j have significant anti-breast cancer activity and are useful as drugs after further refinement.

Biography

Dr. Kalirajan Rajagopal graduated both UG and PG in Pharmaceutical Chemistry at The Tamilnadu Dr. MGR medical University, Chennai. He received his PhD degree in 2013 at JSS University, India. He has 26 years of teaching and research experience and currently working as Professor and Head in department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education & Research, India since July, 2006. He has nominated as BOS member in various universities.  He Published 143 research/review papers with IF range 0.1 to 7.2 and H-index 18 by Scopus and 25 by Google scholar. He also published 13 patents and 16 books. Presented more than 40 research papers in various conferences. Received 5 research grants as PI/Co-PI worth of Rs. 40 lakhs. Organized many conference/ seminar/ workshop etc and received Rs.12.95 lakhs grants from various funding agencies.

Abstract

Background: Breast cancer treatment has improved significantly, contributing to a 5-year relative survival rate of 99% for localized cases. However, post-treatment survivors are reported to have significantly poor cardiovascular fitness which affects their health-related quality of life (HRQoL). In the United Arab Emirates (UAE), evidence for practice addressing post-treatment concerns is scarce.

Objective: To analyse the changes in cardiorespiratory fitness and HRQoL domains for breast cancer survivors in the UAE using a 2-month physical rehabilitation program.

Methodology:
Design: parallel group, randomized controlled trial.
Participants and Setting: The study included breast cancer survivors who were treated with chemotherapy and/or radiotherapy, aged 18-65 years, and able to provide informed consent. Participants were recruited by referral from Al Tawam Hospital, a national referral center for oncology, and Dubai Hospital.

Interventions: The intervention group (IG) received a 2-month individualized rehabilitation program adapted from the BREX program in terms of its training components with 2 supervised sessions and 3 at-home sessions per week. The sessions were held at Thumbay Physical Therapy and Rehabilitation Hospital. The control group (CG) received standard care at their treatment facility. Randomization for subject allocation was double-blinded (conducted by a third party not involved in research) and facilitated through a person not involved in the study.

Outcome: The changes in cardiorespiratory fitness were measured by Cosmed fitmate Pro device while assessing the change in peak oxygen uptake (VO2peak) for the 2 km walk test, and Peak Expiratory Flow Rate (PEFR) by peak flow meter, HRQoL, measured by the QLQ-C30 questionnaire. Outcomes were measured at baseline, post-intervention, and 3 months post-intervention. Allocation of intervention was not blinded due to the nature of the intervention; however, the outcome accessors were blinded.

Results: A total of 62 breast cancer survivors were randomly allocated to the intervention group (n=31) and the control group (n=31). Data from all participants who completed the 5-month trial were analyzed. The intervention group showed a significant improvement from baseline to follow-up in terms of cardiorespiratory fitness: VO2peak increased by 8.3 ± 4.6 mL/kg/min and PEFR by 81 ± 2.73 L/min, while the control group demonstrated a decrease of 1.1 ± 2.1 mL/kg/min and 4 ± 2.48 L/min, respectively (between-group difference, p<0.001). The intervention program was also significantly effective in improving HRQoL in all functional domains of scale except cognitive and social, and there was a notable reduction in the symptoms of fatigue, dyspnea, pain, and sleep disturbances.

Conclusions: The intervention group showed significant improvement in cardiorespiratory fitness and multiple domains of HRQoL among breast cancer survivors in the UAE, which were sustained at 3 months.

Biography

Dr. Animesh Hazari is currently working as an Associate Professor at the College of Health Sciences at Gulf Medical University, Ajman, UAE. He is actively involved in supervising and encouraging research activities of students at undergraduate and postgraduate levels at GMU. He is also supervising and guiding PhD students at international Universities. He is a well-known researcher across the globe for his valuable contribution to areas of Diabetic Foot, Health Aging, Physical Activity, Oncorehabilitation, Biomechanics, and Neuromuscular function, with over 45 indexed publications and multiple guest speakers at international conferences. At GMU, his research output has been significant in terms of internal and external grants. A recently awarded externally funded research grant from the Badminton World Federation has yielded significant outputs. He is also involved in a research grant from the Department of Science and Technology, Govt. of India, on biomechanical analysis in children with cerebral palsy. Dr. Hazari has 2 patents under his name for areas of his work excellence. Adding to his research in academic excellence, he has authored three books published by Springer and five copyrights from the Ministry of Economy, United Arab Emirates.

Abstract

Objective: The purpose of this report was to describe a chiropractic multimodal treatment approach for a patient with a migraine headache.

Clinical Features: A 28-year-old woman with a 14-year history of migraines presented with symptoms of visual disturbances with head and neck pain.

Intervention and Outcome: A multimodal approach of chiropractic care, including chiropractic manipulative therapy and soft tissue therapy for suboccipital, levator scapula, and trapezius muscles, was used. Treatment included 2 visits that were spaced 2 days apart. Based on patient-reported symptoms, the clinician observed clinical improvement and no additional migraine symptoms. Seven months after the initiation of chiropractic care, the patient reported no migraine episodes.

Conclusion: A nonpharmacologic chiropractic approach employing multiple therapies resulted in observable clinical progress for a patient who reported migraine with aura symptoms. (J Chiropr Med 2025;00;1-6)

Key Indexing Terms: Migraine; Chiropractic; Manipulation

Biography

Dr. Adam McRoberts is a chiropractic physician based in Wisconsin, USA. He earned his Doctor of Chiropractic degree from National University of Health Sciences (NUHS) in Illinois. In addition to his chiropractic training, Dr. McRoberts holds two master’s degrees in Sociology and Nutrition/Human Performance.

He is currently pursuing a PhD in Integrative and Functional Nutrition at Saybrook University in California. Dr. McRoberts’ academic and clinical interests focus on musculoskeletal care and the role of integrative approaches in managing complex health conditions. His research areas include epileptic seizures, migraines, and fibromyalgia.

Through his clinical practice and ongoing doctoral research, Dr. McRoberts is committed to advancing evidence-informed approaches that integrate chiropractic care with functional and nutritional strategies to improve patient outcomes.

Abstract

The aging process is characterized by multidimensional changes, including cognitive decline, dysregulation of the autonomic nervous system (ANS), and reduced brain plasticity. In recent years, mind–body exercises such as Yoga and Tai Chi have been suggested to contribute not only to physical flexibility and balance but also to functional brain organization, heart–brain interaction, and cognitive performance. This synthesis study integrates findings related to electroencephalography (EEG), heart rate variability (HRV), and executive functions within a comprehensive framework.
Evidence indicates that regular Yoga practice may induce changes in EEG power bands, particularly increases in alpha and beta activity, which are associated with attention, memory, and executive processes [1]. Moreover, meta-analytic findings report that Yoga and Tai Chi interventions can improve HRV parameters by enhancing parasympathetic activity and balancing sympathetic dominance [2]. HRV has been linked especially to executive functions and decision-making processes, with higher parasympathetic tone often associated with better cognitive performance [3], [4].

Within the framework of the Neurovisceral Integration Model, the functional relationship between vagal tone and the prefrontal cortex supports the role of HRV as a potential biomarker of cognitive regulation [5]. In older adults, increases in HRV associated with executive functions have been observed particularly following long-term exercise interventions [6]. However, some large-scale cohort studies have not identified consistent associations between HRV and cognitive decline, highlighting the heterogeneous and multifactorial nature of this relationship [7].

Overall, current evidence suggests that Yoga and Tai Chi may contribute to cognitive preservation during aging by improving ANS balance, regulating stress responses, and supporting neuroplastic mechanisms. Nevertheless, further long-term randomized controlled trials incorporating biomarker-based assessments are required to clarify causal pathways and to determine which populations may benefit most from specific intervention durations and modalities.

Keywords: Aging; Heart Rate Variability (HRV); Neuroplasticity; Executive Functions; Autonomic Regulation

Biography

Associate Professor Eda Ağaşçıoğlu completed her undergraduate education in 1995 at the Department of Physical Education and Sports at Middle East Technical University (METU). In 1998, she became a part-time Master’s student in Molecular Biology at the Department of Biology, York University, Canada.
In 2000, she completed her first Master’s degree at METU in the Department of Physical Education and Sports, where she investigated the effects of rowing training on muscle strength. In 2003, she completed her second Master’s degree in Molecular Biology and Biotechnology at the Department of Biology, Vrije Universiteit Brussel (VUB), Belgium.

She earned her Ph.D. in 2007 from the Department of Sports Sciences and Technology at Hacettepe University, focusing on protein oxidation markers in cardiac muscle under hypoxic conditions. Between 2010 and 2012, she conducted postdoctoral research as a The Scientific and Technological Research Council of Türkiye (TÜBİTAK) at the METU Central Laboratory, investigating oxygen-sensitive soleus muscle gene expression levels in acute and chronic hypoxia.
Additionally, Dr. Ağaşçıoğlu worked as a research fellow at the Defence and Civil Institute of Environmental Medicine (DCIEM), Canada (1997–1998), and at Université Libre de Bruxelles (ULB), Belgium (2003–2005). Dr. Ağaşçıoğlu is currently conducting research on the effects of exercise on the aging process in brain tissue.

She currently serves at Istanbul Rumeli University, Faculty of Sports Sciences, Department of Exercise and Sports Sciences.

Abstract

The age-old Indian healthcare practice known as Ayurveda places a high value on mental, physical, and spiritual equilibrium for a healthy lifestyle. Ayurveda, which has historically relied on alternative treatments and lifestyle modifications, provides a holistic strategy for health. Improving the reliability, accuracy, and international acceptability of Ayurvedic medicine requires incorporating recent scientific and technical developments for most disease control including wound healing.

Dermal patch technology has greater advantage over other wound healing managements for its minimum side effects, controlled and fast drug release. Amongst dermal patches, scaffold has a greater advantage over films and dry powder because of its porous structure which help in greater aeration of the wound. Traditional medicine from plant extract (Panchavalkal) and other traditional mineral have been used to prepare various formulations in the form of hybrid scaffolds using biodegradable polymer matrix. The drug was dispersed uniformly. In – vitro drug release study shows that the release kinetics is much faster in case of hybrid scaffold as compared to pure polymer film. The cause of slow release has been worked out through spectroscopic techniques. It is also observed that drug is spontaneously released till 5 days which minimize the damages of the healthy granulation and epithelial tissues due to wound dressing. A preliminary clinical trial has been performed by applying the hybrid scaffold of biodegradable polymer which exhibit remarkable wound healing ability. Hybrid scaffold has lot of advantages over commercial patch as it is more porous and permeable for wound exudates and easily detachable from wound for redressing.  Rate of wound healing using hybrid scaffold dressed wound was found to be faster as compared to wound dressed with normal gauze dressing soaked with traditional medicine.

Biography

Dr. Pralay Maiti is currently a senior professor and ex-coordinator in the School of Materials Science and Technology, IIT (BHU), Varanasi. Prof. Maiti has received his Master in Chemistry from Indian Institute of Technology, Kharagpur in 1991 and Ph.D. in Polymer in 1996 from The Indian Association for the Cultivation of Science (Jadavpur University). He was COE Researcher and Lecturer at Venture Business Laboratory, Hiroshima University, Japan (1997-1999) and was post-doctoral fellow at Toyota Technological Institute, Japan (1999-2001). He was Visiting Scientist at Cornell University, USA from 2002 to 2004. He was Quick Hire Fellow at Central Leather Research Institute, Chennai before joining the School of Materials Science and Technology as Reader in December 2004. His current research interests include drug delivery vehicle, biomaterials and energy materials.

Most innovative contribution of Prof. Maiti is in the field of materials chemistry related to drug delivery using biodegradable polymers, self-assembly and formulation of traditional medicine for wound care, hemostatic patch and bone healing. He has published more than 270 papers in high impact peer reviewed journals, 39 patents (few of them are commercialized), 34 book chapters and h-index of 61 and his citation is more than 18,500. Prof. Maiti is the recipient of many awards like National award for Technology Innovation, APA Young Scientist award, Prof. Santappa Silver Jubilee medal, NASI-Reliance platinum jubilee award, Tata innovation fellowship, Advanced Materials Award, Dare to Dream 4.0 are few of them. He is a fellow of Indian National Academy of Engineering (FNAE), West Bengal Academy of Science and Technology (FAScT) and International Association of Advanced Materials.

Abstract

Over the last 20 years, increasing evidence has shown that mindfulness meditation effectively reduces stress while improving mental and physical health, as well as cognitive abilities. While neuroimaging research has begun to pinpoint specific brain areas and networks linked to these positive effects, the exact neural mechanisms driving these changes remain poorly understood. Mindfulness, which is defined as the practice of being aware of the present moment without judgment, has emerged as a key topic in modern neuroscience research.

A detailed search of five international databases—Web of Science (WOS), PubMed, Embase, Scopus, and the Cochrane Library—was conducted to identify original research articles published between 2017 and 2024 that examined the effects of mindfulness practices using magnetic resonance imaging (MRI).

The results reveal that meditation activates and alters brain areas associated with self-referential processing, self-regulation, focused attention, adaptive behaviour, interoceptive awareness, and problem-solving. Both structural and functional neuroplastic changes were noted in meditators, especially in regions related to self-awareness and cognitive control, as well as in extensive functional brain connectivity networks.

Overall, the evidence indicates that identifiable biological mechanisms support mindfulness meditation and may aid in disease prevention and in enhancing overall health. These results provide a neuroscientific basis for understanding the extensive benefits of meditation and highlight its potential as a preventive and therapeutic approach.

Key words: Mindfulness, brain networks, self-regulation, functional connections

Biography

Dr. Mamta Trichal is a Senior Lecturer of social work, hosted in the Department of Sociology and Anthropology at the University of Dar es Salaam. She holds a PhD from Mahatma Gandhi Kashi Vidyapeeth and a Postgraduate Diploma in Clinical Psychology from Global Institute of Medical Sciences (GIMS).

With over two decades of academic and clinical experience across India and Tanzania, Dr. Trichal specializes in mental health, gender studies, criminology, social psychiatry, and public health. Her interdisciplinary work bridges sociology, psychology, and community health, with a strong focus on vulnerable populations including women, children, adolescents, and the elderly. She has 12 publications in peer-reviewed, indexed national and international journals; authorship of 2 books; and a contribution to 1 book chapter with a reputed publisher. Dr. Trichal’s recent research centres on mindfulness and neuropsychological well-being, including a 2026 systematic review on mindfulness and brain connectivity and a book chapter on its application in borderline personality disorder. Dr. Trichal’s scholarship reflects a deep commitment to advancing evidence-based mental health practices, particularly mindfulness-based approaches that bridge neuroscience, psychology, and social well-being. Trichal has also led funded research projects on child abuse and delinquency, community mental health awareness, and psychosocial risk factors. In addition to her scholarly contributions, she has extensive experience in clinical counselling, psychiatric social work, family and marital therapy, and academic mentorship.

Her work demonstrates a sustained commitment to advancing mental health research through mindfulness studies, while integrating social science perspectives with advocacy and community-based interventions.

Abstract

Berberis aristata (B. aristata), commonly known as Daruhaldi, is a spinous herb belonging to the Berberidaceae family and is native to the Northern Himalayas. Traditionally, and in Ayurvedic medicine, it has been used for its antibacterial, anti-inflammatory, and anti-neoplastic properties, as well as an intestinal antiseptic and bitter stomachic. The present study aimed to evaluate the therapeutic effects of a standardized B. aristata bark extract in an acetic acid induced colitis model in mice. Phytochemical analysis, quantitative estimation of phytoconstituents, and chromatographic profiling (TLC and HPTLC) were performed to characterize the extract. Colitis was induced via intra-rectal administration of acetic acid (150 µL, 5%) on day 8. The extract was administered orally at doses of 12.5, 25, and 50 mg/kg for 11 consecutive days. Disease severity was assessed by measuring colon length, spleen weight, ulcer area, and ulcer index, along with histological evaluation using hematoxylin and eosin (H&E) staining. Phytochemical analysis confirmed the presence of carbohydrates (26.25 dextrose equivalents), reducing sugars, proteins, flavonoids (5.64 mg/g), alkaloids (0.24% w/w), and total phenolic content (11.58 mg/g). TLC analysis yielded an Rf value of 0.39, while HPTLC, performed using an n-propanol: water: formic acid (90:8:0.4) solvent system, revealed two distinct spots. Administration of B. aristata extract (12.5 mg/kg) significantly ameliorated macroscopic and histological damage, reduced malondialdehyde (MDA) levels, and preserved glutathione (GSH) and catalase (CAT) activity in affected tissues. Furthermore, inflammatory markers, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), myeloperoxidase (MPO), and cyclooxygenase (COX) activity, showed significant improvement in the treatment groups compared to the acetic acid-induced colitis group. Liver function markers (SGOT, SGPT) remained statistically non-significant relative to the control group. The protective effects of B. aristata extract may be attributed to its ability to modulate oxidative stress and inflammatory pathways at the colorectal site, likely due to the presence of berberine and other bioactive phytoconstituents.

Keywords: Berberis aristata, colitis, oxidative stress, inflammatory markers, phytochemicals, berberine

Biography

Dr. Venkata Suresh Babu Agala, currently serving as a Dean at School of Pharmacy, G.H. Raisoni Skill Tech University, Nagpur, and Maharashtra, India. With 16 years of comprehensive experience in teaching, research, and administration, I have contributed significantly to the field of Pharmacy. My research endeavors include 50 published articles in various indexed National and International journals, authoring 8 textbooks, and contributing a book chapter to reputed publishers like Elsevier and Springer and 2 patents granted and 8 patents published.

Abstract

The seasonal flu virus can cause serious illness or death. Medical therapies and vaccinations have reduced influenza infections, yet they remain a public health hazard. Folk medicine uses Canarium patentinervium Miq, to cure respiratory problems and inflammation. Nevertheless, little is known about this plant’s antiviral properties. This study aims to test the antiviral activity of several extracts and isolated compounds from Canarium patent- inervium Miq. against the H1N1 virus in insilico and invitro models. The leaf and bark ethanol extracts exhibited the highest activity, with CC50 > 300 μg/mL, IC50= 30.2 μg/mL, and SI = 10. Catechin was isolated from the plant leaf and bark along with scopoletin, scoparone, hyperin, and cynaroside. All the isolated compounds were tested against H1N1 drug targets neuraminidase, hemagglutinin, and matrix protein 2 in insilico study. Catechin had the highest affinity (ΔG= − 10.4 Kcal/mol) and binding free energy (ΔGbind= − 92.6 ± 0.3 KJ/mol) for matrix protein 2. The in vitro investigation demonstrated that catechin had minimal toxicity and some effect on the H1N1 virus (CC50>300 μg/mL, IC50= 41.5 μg/mL, and SI = 7). Catechin and oseltamivir synergy was tested using virus yield reduction assays. Influenza decreased significantly by oseltamivir-catechin at 1 and 100 μg/mL dosages with strong synergy indicated through viral titer. For the first time, the antiviral activity of the Canarium patentinervium miq plant was reported in this study, and it suggests that using plant phytochemicals in combi- nation with oseltamivir may improve flu outcomes, especially for patients who are very sick or immunocompromised.

Biography

Dr. Najwan Jubair holds a PhD in Pharmaceutical Sciences from UCSI University, Malaysia, where she was awarded the Outstanding PhD Award (2023) in recognition of her research excellence and six peer-reviewed publications completed during her doctoral studies. She currently serves as the Head of Research at the College of Pharmacy, Al-Ameen University, Baghdad, Iraq.

Dr. Jubair’s research expertise lies in natural product chemistry, drug discovery, and organic synthesis, with a strong focus on the isolation, structural elucidation, and biological evaluation of bioactive compounds derived from medicinal plants. She is actively involved in a national collaborative project documenting Iraqi medicinal flora with therapeutic potential, in partnership with SAWA Pharmaceutical Manufacturer in Iraq. Her work aims to integrate traditional botanical knowledge with modern pharmaceutical research to support drug development and promote sustainable utilization of Iraq’s plant biodiversity.

Abstract

Milk thistle (Silybum marianum) is a medicinal plant recognized for its high content of phenolic compounds, notably flavonolignans, flavonoids, and simple phenolic acids, which contribute to its significant antioxidant and hepatoprotective activities. This study aimed to characterize the biochemical composition and to assess the activities of key enzymes—phenylalanine ammonia lyase (PAL) and polyphenol oxidase (PPO)—involved in phenolic biosynthesis in various plant parts and commercial extracts across different growth stages. Plant samples, including leaves, stems, flowers, seeds, and commercial extracts, were collected monthly over a six-month period, and standard protocols were used for biochemical and enzymatic analyses. Results showed that PPO and PAL activities peaked at the fourth and third month, respectively, then declined, with aerial parts exhibiting higher activity than flowers, seeds, or commercial extracts. Total phenols and flavonoids increased with plant age, while carotenoids, chlorophylls, and β-carotene showed distinct temporal patterns. Notably, commercial extracts demonstrated negligible enzyme activity and generally lower levels of bioactive compounds. Study limitations include limited sampling frequency, absence of environmental data, and a lack of individual phenolic profiling or bioactivity assays. Future research should employ advanced metabolite identification, assess additional enzymes and gene expression, integrate environmental monitoring, and directly evaluate biological activities. These findings provide insight into the dynamic biochemical profile of milk thistle and highlight areas for further investigation to optimize its medicinal use.

Keywords: Silybum marianum, Phenylalanine ammonia-lyase, Polyphenol oxidase, Secondary metabolites, Developmental stages, Hepatoprotective compounds.

Biography

Mohmmad Asif Gawhari earned his bachelor’s degree in Chemistry from Kabul University in 2016. He subsequently served as a Biochemistry Lecturer at Melat Medical Institute. In 2019, he pursued a master’s degree in Clinical Biochemistry in India, completing the program in 2021. He is currently a Ph.D. scholar in the Department of Biotechnology and Food Technology at Punjabi University, Patiala. His doctoral research focuses on the phenolic characterization of Silybum marianum using bio-analytical techniques and the in vitro evaluation of its hepatoprotective potential.

Abstract

So far, we had more new, modern and scientific awareness about the issues of TEM as follows:

Modernized & scientificized concepts of the TEM: Yin, yang, jing, qi, shen, xue, jin, ye and qi gong’ therapy belong to the TEM. We had awarenesses about these  issues as follows: The yin 陰includes: The anabolism, metabolic materials, zang, etc. The yang 陽includes: The catabolism, metabolism, fu, etc. The qi 氣is the metabolism. The xue 血is the metabolic materials. The jing 精is the genotype or structure. The shen 神is the phenotype or function. The true qi gong 氣功will be adjusted or restored or changed the metabolisms of the body or any of the part follow wish. All those things created the developed TEM more modernly, scientificly, fastly.

Modernized & scientificized Yin Yang theory be applied in the Medicine: The yin yang’ 陰陽 theory is very important theory of TEM. When applied in the medicine, we have realized its contents according to the bases of modern science. All related to the anabolism, catabolism, metabolism and metabolic material of the body (The most important issues for the health of the human as well as every living organism).  When being disease, that’s the imbalances by or increase or/and reduction of those issues at the one or many certain zang fu 臟腑, jing luo 經絡 in the body. The treatments by the herbal medicine, acupuncture, moxibustion, etc are the bio-physicochemical interactions to adjust and recuperate those imbalances of so issues at the corresponding ill zang fu, jing luo. The prevention is also therapies, solutions aim avoid create those imbalances of so issues in the body. All those things help also us more realize that: “The Creator is very perfect”.

Hypotheses about the structure of Meridian – Acupoint’ system (MAS) & interactive mechanism of Acupuncture and Moxibustion therapies (IMAMT) : We had two hypotheses about the structure of  MAS & IMAMT. The MAS is a stretching convergence of the cell’ organizations have metabolisms in close connection with the functions of each acupoint, each meridian, each viscera and of entire meridian system at connective system. The IMAMT is adjustment and recuperation of the physicsochemical properties of the interstitial fluid, whereby will be adjusted and recuperated the metabolisms at some acupoints, at the meridian, at the viscera and entire meridian system. So, our two hypotheses ensure the problem that the structure always fits with the function by the metabolisms and also coincide with the current views: Should research on the cell’s organizations at the MAS at the more deep and wide levels. At the same time, those hypotheses can fully explain the concepts in the acupuncture and moxibustion books as well as in the facts. When testing those hypotheses, we very need to be received the scientists’ helps in many fields of the Biomedicine.

We had two hypotheses about the structure of  MAS & IMAMT. The MAS is a stretching convergence of the cell’ organizations have metabolisms in close connection with the functions of each acupoint.

Biography

Thuy Nguyen Minh has been involved in medical education and clinical practice for nearly four decades. From 1986 to 2024, he lectured on Traditional Eastern Medicine (TEM) at Haiphong University of Medicine and Pharmacy. Between 2007 and 2017, he served as Head of the Department of Traditional Medicine at Haiphong Medical University Hospital. From 2006 to 2024, he was a Master’s degree holder and principal lecturer at Haiphong University of Medicine and Pharmacy. Since May 2024, he has been a member of the Vietnamese Acupuncture Association.

Abstract

The Census of India 2011 defines ‘houseless household’ as, “households who do not live in buildings or census houses but live in the open on roadside, pavements, under flyovers and staircases, or in the open in places of worship, mandaps, railway platforms, etc.” India had 17.73 lakh unhoused people, with over 700,000 of them being women. Tuberculosis (TB) affected an estimated 8.7 million people …. globally in 2011, including 0.5 million women. Biography: Short biography of Presenting author and attach latest HD photo. The WHO has set targets to end the global TB epidemic by 2035. In India Revised National Tuberculosis Control Program [called National TB Elimination Program (NTEP) since 2020] set out National Strategic Plan for Tuberculosis: 2017-25 for Elimination By 2025.

Humana People to People India (HPPI) newer projects -TASA (TB Affected Street Activist) and SWEET (Street Women Empowered and Engaged to Stop TB) — specifically focus on homeless and street-dwelling women. The objectives of study on two projects: 1. To understand the determinants of Tuberculosis and assess barriers to TB care faced by homeless people, poor migrant workers and people living in unauthorized slums of Delhi. 2. To assess the “effectiveness of community -based interventions—specifically the TASA and SWEET projects — in empowering homeless and other vulnerable and marginalised people in Delhi to increase TB awareness, enhanced community-level engagement, improved participation of women, better access to social entitlements, and reduction in TB related stigma. 3. To demonstrate that trained homeless women can function as effective health advocates by identifying presumptive TB cases, facilitating testing, supporting treatment adherence, and addressing TB related stigma and discrimination in their communities.

Biography

Dr. Joyce Felicia Vaghela, MPH (Johns Hopkins University, USA) and MBBS (Christian Medical College & Hospital, Punjab), is a public health professional with over two decades of experience in community health and hospital administration. She served as the former Head of the Community Health Department at St. Stephen’s Hospital, Delhi, and was an active faculty member for 21 years (1999–2020). During her tenure, she led and implemented several impactful projects, including Mother NGO initiatives for homeless citizens; community development and health programs with Humana People to People Foundation for elderly populations and adolescents; home-based care for MDR-TB patients in collaboration with Eli Lilly and United Way Worldwide; a community mental health project with The Hans Foundation; and the Swastha Saarthi preventive health program for auto and taxi drivers with Indraprastha Gas Limited. Dr. Vaghela is the first author of over 25 published research papers and also served as Deputy Director (Material Management) from 2011 to 2020. In addition, she chaired multiple institutional committees, including Emergency Preparedness and Disaster Management and the Internal Complaints Committee for the Prevention of Sexual Harassment at the Workplace.

Abstract

Autoimmune disease is now recognized as one of the most pervasive chronic health challenges of the modern era, affecting an estimated 50 million Americans and growing globally. Despite this epidemic, most conventional approaches remain focused on symptom suppression rather than root-cause resolution. In this presentation, we examine a deeper and more integrative paradigm, the Gut-Autoimmune Axis, to uncover where inflammation truly begins, and how restoring gut and immune harmony can offer lasting healing.

This talk bridges the worlds of functional medicine and Ayurveda to present a unified theory of chronic disease progression and reversal. At the core of both traditions lies a foundational truth: digestion governs immunity. When gut integrity is compromised, whether through dysbiosis, food sensitivities, stress, environmental toxins, or suppressed digestive fire, both modern and ancient systems agree that systemic inflammation and immune dysregulation soon follow.

We explore the physiological mechanisms behind intestinal permeability (leaky gut) and its role in triggering autoimmune responses via immune overactivation, molecular mimicry, and loss of oral tolerance. This is then juxtaposed with the Ayurvedic concept of ama, a toxic metabolic residue formed from incomplete digestion, which similarly travels through the system, blocks bodily channels (shrotas), and gives rise to inflammation, fatigue, and disease.

Through clinical case examples and detailed treatment frameworks, Dr. Singh will demonstrate how the integration of functional lab testing, gut-repair protocols, Ayurvedic digestive strategies, herbal medicine, and nervous system regulation creates a multi-layered, high-impact roadmap for reversing chronic autoimmune presentations. Real-world outcomes, including symptom reduction, improved lab markers (zonulin, antibodies, microbiome), and enhanced quality of life, will be highlighted.

This presentation is ideal for practitioners, clinicians, and wellness professionals seeking to deepen their understanding of gut-autoimmune connections and develop truly integrative, systems-based approaches that go beyond pills, protocols, or symptom chasing.

REFERENCES:

• Fasano (2012). Leaky Gut and Autoimmunity. Clinical Reviews in Allergy & Immunology
• Rescigno (2017). Gut Barrier Function. Trends in Immunology
• Tripathi D. (2003). Essentials of Medical Pharmacology (Ayurveda)
• Tiwari (2009). Ayurveda: A Comprehensive Guide
• Kshirsagar , Nagpaul M. (2011). The Answer to Cancer

Biography

Dr. Bhavna Singh, ND, AP, is a Naturopathic Doctor and Ayurvedic Practitioner specializing in gut health, autoimmune healing, and functional lab integration. Through her signature Functional Ayurveda approach, she bridges ancient Ayurvedic wisdom with cutting-edge functional medicine to help clients uncover root causes, restore digestion, and rebalance the immune system. Dr. Singh’s clinical focus includes digestive disorders, hormone imbalance, and chronic inflammation. A sought-after speaker and educator, she empowers both patients and practitioners with practical, holistic tools to heal from the inside out, starting with the gut. She is the founder of the high-touch healing program Gut Revive.

Abstract

The objective of this systematic review is to assess the effectiveness and safety of Chinese Herbal Medicine (CHM) for anxiety disorders and obsessive-compulsive disorder (OCD). EMBase, PubMed, CINAHL, CNKI, Wanfang, CQVIP, clinicaltrials.gov and Chinese Clinical Trial Registry were searched from database inception to January 2025 using search terms defining “anxiety/OCD”, “Chinese herbal medicine” and “randomized controlled trial”. From a total of 9,805 reports screened, 92 randomised-controlled trials in which CHM was tested against anxiolytics in the treatment of anxiety disorders and OCD were included in the review. The sample size, mean and standard deviation at end-of-intervention (for continuous outcomes) and number of participants who experienced adverse events were collected for each arm. Compared to anxiolytic medication, CHM was more effective in reducing anxiety (Hamilton Anxiety Rating Scale Mean Difference = -1.50 points, 95% CI -2.21 to -0.78, p < 0.001) and produced fewer adverse events (Incidence Rate Ratio = 0.33, 95% CI 0.24 to 0.45, p < 0.001) in participants with generalized anxiety disorder. These results are supported by studies with a low risk of bias. No study with a low risk of bias tested CHM for panic disorders and OCD. This systematic review indicates a favourable risk/benefit profile of CHM compared with anxiolytic medication for GAD, and therefore CHM could be considered as an alternative to anxiolytics. Studies with a low risk of bias are required to assess the effectiveness of CHM for panic disorders, phobic disorders and OCD.

Biography

Dr. Yoann Birling is a Chinese medicine practitioner, lecturer, and researcher with a strong commitment to mental health and integrative medicine. Trained at the top Chinese medicine university in the world, he brings extensive clinical and academic experience, having contributed to more than 30 clinical studies and authored over 25 academic publications. Dr. Birling is a leading advocate for a holistic, evidence-informed approach to mental health—one that moves beyond one-size-fits-all models and embraces the full range of effective therapeutic options. His work focuses on improving community mental health outcomes while optimizing the use of resources through rigorous, high-quality research.

Abstract

Traditionally viewed as detrimental to performance, mental fatigue and cognitive overload are increasingly being reinterpreted through the lens of adaptive neuroplasticity. In this presentation, I introduce a novel framework positioning cognitive load—especially in the form of deliberate mental fatigue induction through Brain Endurance Training (BET) as a potent catalyst for enhanced conscious experience, including access to flow states and mindfulness-like awareness. Drawing from neuroscience, sport psychology, contemplative science, and consciousness research, I synthesize findings that support a common neural pathway underpinning BET, mindfulness training, and the flow experience.

BET, originally designed to train cognitive resilience in athletes, involves prolonged response-inhibition tasks (e.g., Stroop, n-back) during or around physical training. Recent neuroimaging data show that BET increases structural-functional coupling in core executive and salience network regions—including the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and anterior insula—while concurrently downregulating activity in default mode network (DMN) regions such as the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). These changes reflect a brain reconfiguration similar to what is observed in mindfulness meditation and flow: increased task-positive network efficiency, reduced self-referential processing, and heightened interoceptive awareness.

Mindfulness training, especially in athletes, has shown to improve inhibitory control, decrease subjective mental demand, and foster attentional stability during high-load states. Neurobiologically, mindfulness is associated with enhanced engagement of the ACC and insula, supporting focused awareness and non-reactivity. Similarly, flow states are characterized by intense task immersion, diminished self-monitoring, and intrinsic reward, underpinned by a unique neural signature: activation of DLPFC, ACC, insula, and motor areas, with deactivation of the DMN, amygdala, and memory-related medial temporal lobe structures.

These converging findings suggest a shared tri-network dynamic: flow and meditative states arise when the salience network (ACC, insula) detects challenge and mobilizes the central executive network (DLPFC, parietal cortex) while suppressing DMN activity. BET appears to trigger this same reconfiguration through sustained cognitive challenge. The result is a state of high neural efficiency, low emotional reactivity, and deep task absorption—a flow-ready brain.

Importantly, both BET and mindfulness produce these changes without altering physiological markers of fatigue (e.g., heart rate, blood lactate, muscle metabolism), implying a central rather than peripheral adaptation. In this way, deliberate exposure to cognitive load combined with physical training may paradoxically reduce the felt cost of mental effort while enhancing focus and awareness. Such outcomes raise compelling questions: Can cognitive stress, when applied systematically, serve as a training vehicle for accessing altered states? Is flow an emergent property of optimized brain network dynamics?

By bridging high-performance training, contemplative neuroscience, and flow theory, this framework redefines the role of cognitive effort. It positions potentially BET not merely as a performance enhancer but as a consciousness-modifying tool; a cognitive pathway to the same states sought through meditation and spiritual practice. In doing so, it opens the door to future interdisciplinary research exploring how cognitive demand, far from being an obstacle, might be a gateway to expanded states of awareness.

Biography

Dr. Walter Staiano is a cognitive neuroscientist and performance psychophysiologist exploring how mental fatigue, mindfulness, and cognitive load affect both cognitive and physical performance, while also serving as gateways to flow and expanded consciousness. A pioneer in the study of mental fatigue and sport performance, he is also known for developing Brain Endurance Training (BET), a method that enhances both cognitive and physical resilience while altering brain network dynamics similarly to meditation. His work seeks to push the boundaries of human performance by bridging neuroscience, psychophysiology, and contemplative practice, offering a novel framework to rewire the mind towards heightened presence and awareness.

Abstract

In our modern quest for health, we often separate the mind, the body, and the spirit. Yet within every embodied being lies a subtle decoding system: one where emotional memory images (EMIs) serve as pre-conscious patterns linking experience, autonomic regulation and immune-inflammatory responses. Drawing on my model of Split-Second Unlearning (SSU), I propose that EMIs act as implicit ‘information networks’ that, when unintegrated, may provoke dys-coherence in the neuro-immune system and trigger neurogenic inflammation, pain sensitivity and chronic dysregulation.

In this keynote I will:

1. Outline how emotional memories (especially those rooted in adverse childhood experiences) embed themselves as high-fidelity prediction networks, driving autonomic and interoceptive responses outside conscious control.
2. Map how this information-driven dys-coherence can manifest in the immune system (via peptides such as CGRP), microglia, mast cells and macrophages – thus forging a bridge between emotional experience and inflammation.
3. Explore the concept of coherence as a pivotal therapeutic goal – including how ancient traditions (e.g., in Ayurveda, TCM, indigenous healing) already lift the mind-body membrane by restoring alignment between subtle pattern, physiology and environment.
4. Illustrate how the intervention method of SSU enables rapid recalibration of emotional-memory networks, enabling reconsolidation, restoration of heart-brain afferent rhythms, autonomic balance, and neuro-immune homeostasis.
5. Propose integration pathways for traditional and alternative medicine settings: how clinicians may apply coherence-based frameworks to support somatic, emotional and immunological healing.
6. Conclude with a call for research synergy: merging fractal theory, information-theory, extracorporeal memory models and traditional healing practices into a unified paradigm of “information drives inflammation (or its resolution)”.

If we succeed in re-framing emotional memory as information that literally regulates physiology, we open exciting avenues for synergy between cutting-edge neuroscience, trauma-informed therapy, and ancient holistic systems. My hope is that this keynote will not only illuminate a new therapeutic frontier but also invite practitioners of traditional medicine to consider how the invisible architecture of emotional memory may hold the key to resilient, coherent health.

Biography

For more than 25 years, Matt Hudson has dedicated his career to exploring the complexities of the human mind through disciplines such as neuroscience and quantum physics. His unique personal journey has equipped him with an exceptional ability to help individuals overcome mental and emotional challenges—often uncovering underlying issues that may go unnoticed by conventional practitioners. A pivotal moment in Matt’s life came after undergoing ear surgery. During his post-operative consultation, the surgeon expressed astonishment that Matt was able to speak at all, given the condition of his ears. This revelation led Matt to recognise that his ability to communicate did not rely primarily on auditory input. Instead, he had developed an extraordinary sensitivity to subtle, non-verbal cues—micro-movements in the hands, slight facial expressions, and other nuanced signals tied directly to human neurology. This deeper form of communication now forms the foundation of Matt’s work. By tuning into these micro-signals, he helps people access and resolve challenges at the neurological level, empowering them to achieve lasting change.

Abstract

Context: Medicinal and aromatic plants play a central role in the therapeutic, dietary, and cosmetic practices of local populations.Objectives: To highlight traditional knowledge and inventory the diversity of flora and associated ethnobotanical practices.

Methods: Between March 2024 and March 2025, an ethnobotanical survey was conducted among 406 inhabitants of the Fez-Meknes region. The information collected through semi-open interviews on medicinal, dietary, and cosmetic uses was used to calculate the family use value (FUV), the use value (UV), the value of the plant parts used (PPV), and the informant agreement index (IAR). A multiple correspondence analysis (MCA) was also conducted to explore the links between plant uses and the sociodemographic characteristics of the respondents.

Results: The study identified 123 species belonging to 55 botanical families. Lamiaceae dominated the flora studied (FUV = 0.154), while Ajuga iva had the highest use value (UV = 0.57). Maceration was the most common method of preparation (63.87%), and leaves were the most commonly used plant part (PPV = 0.78). Painful and inflammatory conditions were the most frequently reported therapeutic category (IAR = 0.96).

Conclusions: The results highlight the richness of local biodiversity and traditional knowledge, while emphasizing the need for further phytochemical and pharmacological research to scientifically support therapeutic, food, and cosmetic uses.

Keywords: Ethnobotany, medicinal and aromatic plants, Fez-Meknes, phytotherapy.

Biography

Meryem Doubi, third-year doctoral student at the Faculty of Sciences of Ibn Tofaïl University, Morocco, where shework at the Natural Resources and Sustainable Development Laboratory. Her research focuses on medicinal plants in the Fez region, their biological activities, and their therapeutic applications. She is also interested in secondary metabolites, their extraction methods, and phytochemical screening. As a recipient of the CNRST “PASS” scholarship, she involved in several research projects and aim to develop environmentally friendly solutions based on plant resources.

Abstract

Obesity, along with dyslipidemia and hyperglycemia, is a metabolic disorder growing in prevalence that is linked to chronic diseases such as atherosclerosis, hypertension, and type 2 diabetes. This study evaluated the anti-obesity, lipid-lowering, and anti-hyperglycemic effects of CB-02 capsules containing dry extracts of Phyllanthus emblica L., Dendrobium cate natum Lindl., and Gynostemma pentaphyllum in  HFD (High-fat diet)-induced obese Swiss albino mice. After 12 weeks of HFD induction, mice were treated orally with CB-02 (576 or 1152 mg/kg/day) for 8 weeks. CB-02 significantly reduced Body weight gain, Abdominal circumference, the Lee obesity index, and the relative weights of visceral fat and major organs. It also improved lipid profiles by decreasing  TC (Total cholesterol), TG (Triglyceride), LDL-C (Low-density lipoprotein cholesterol), and non-HDL-C (Non-high-density lipoprotein cholesterol), while increasing HDL-C (High-density lipoprotein cholesterol). These effects were comparable to orlistat (60 mg/kg/day). Furthermore, CB-02 lowered fasting glucose and improved insulin sensitivity, as indicated by an increased QUICKI (Quantitative insulin sensitivity check index) and HOMA-β (Homeostatic model assessment for β-cell function) and reduced HOMA-IR (Homeostatic model assessment for insulin resistance). Histopathological evaluation showed that CB-02 reduced hepatic steatosis and inflammatory cell infiltration and also attenuated β-cell morphological alter ations and pancreatic histopathological damage. These results suggest that CB-02 may be a promising therapeutic candidate for managing obesity and its comorbidities, including dyslipidemia, hyperglycemia, and hepatic steatosis, contributing to the prevention of type 2 diabetes and cardiovascular diseases in obese individuals.

Biography

Dr. Le Hong Phu is a lecturer, researcher, and Deputy Director serving as Head of the Cardiology–Nephrology–Rheumatology Department at the Vietnam Military Institute of Traditional Medicine, located at 442 Kim Giang, Dinh Cong, Hanoi. He earned his Ph.D. from the Shanghai University of Traditional Chinese Medicine in 2006, following a Master of Science degree from the Military Institute of Traditional Medicine in 2001 and a Bachelor of Science from the Vietnam Military Medical University in 1992. Since 2010, Dr. Phu has been deeply engaged in evaluating the pharmacological activities of herbal medicines, natural products, and traditional formulations, particularly in experimental models of metabolic, cardiovascular, renal, and inflammatory disorders. His work also includes assessing toxicity and safety profiles of natural compounds in experimental animals and conducting clinical evaluations of the efficacy and safety of traditional medicine–based therapies. His primary research focuses on the pharmacological and clinical evaluation of herbal medicines and traditional formulations for metabolic, cardiovascular, and renal diseases, and he has published four scientific papers indexed on Google Scholar.

Abstract

Obesity, along with dyslipidemia and hyperglycemia, is a metabolic disorder growing in prevalence that is linked to chronic diseases such as atherosclerosis, hypertension, and type 2 diabetes. This study evaluated the anti-obesity, lipid-lowering, and anti-hyperglycemic effects of CB-02 capsules containing dry extracts of Phyllanthus emblica L., Dendrobium cate natum Lindl., and Gynostemma pentaphyllum in  HFD (High-fat diet)-induced obese Swiss albino mice. After 12 weeks of HFD induction, mice were treated orally with CB-02 (576 or 1152 mg/kg/day) for 8 weeks. CB-02 significantly reduced Body weight gain, Abdominal circumference, the Lee obesity index, and the relative weights of visceral fat and major organs. It also improved lipid profiles by decreasing  TC (Total cholesterol), TG (Triglyceride), LDL-C (Low-density lipoprotein cholesterol), and non-HDL-C (Non-high-density lipoprotein cholesterol), while increasing HDL-C (High-density lipoprotein cholesterol). These effects were comparable to orlistat (60 mg/kg/day). Furthermore, CB-02 lowered fasting glucose and improved insulin sensitivity, as indicated by an increased QUICKI (Quantitative insulin sensitivity check index) and HOMA-β (Homeostatic model assessment for β-cell function) and reduced HOMA-IR (Homeostatic model assessment for insulin resistance). Histopathological evaluation showed that CB-02 reduced hepatic steatosis and inflammatory cell infiltration and also attenuated β-cell morphological alter ations and pancreatic histopathological damage. These results suggest that CB-02 may be a promising therapeutic candidate for managing obesity and its comorbidities, including dyslipidemia, hyperglycemia, and hepatic steatosis, contributing to the prevention of type 2 diabetes and cardiovascular diseases in obese individuals.

Biography

Nguyen Hoang Ngan is a lecturer and researcher at the Vietnam Military Medical University, where he currently serves as Head of the Department of Pharmacology at the Institute of Pharmacy Education. He earned his Ph.D. from Toyama University in Japan in 2014, following a Master of Science degree in 2005 and a Bachelor of Science degree in 1999, both from the Vietnam Military Medical University. His work focuses on evaluating the pharmacological properties and toxicity of drugs and natural products, including their antioxidant, anticancer, anti-inflammatory, anti-diabetic, wound-healing, and immune-boosting activities. He also conducts clinical assessments to determine the efficacy and safety of these substances. His research centers on the biological, pharmacological, and clinical effects of drugs and natural compounds, and he has published 21 scientific papers indexed on Google Scholar.

Abstract

Women of all ages, starting from puberty, often encounter challenges related to premenstrual syndrome (PMS) and menstrual symptoms. These challenges can include abdominal pain and psychological effects such as stress and anxiety, which can significantly impact brain function. Primary dysmenorrhea, characterised by painful menstrual cramps without identifiable pelvic pathology, affects a significant proportion of women of reproductive age, often impairing quality of life and daily functioning. Non-pharmacological interventions such as Yoga Asanas have been increasingly recognised for their potential to modulate pain perception and improve physiological balance. However, the neurophysiological mechanisms underlying these effects remain inadequately explored.

Objectives: This study aims to assess the therapeutic impact of selected Yoga Asanas on primary dysmenorrhea in young women by evaluating neurophysiological responses using electroencephalographic (EEG) recordings and applying deep learning techniques for pattern classification.
This interventional study was conducted young female engineering college students aged 18 to 25, lasting for six months. Participants were selected for the intervention group and the control group after obtaining informed consent. The intervention group underwent a supervised 24-week yoga program, focusing on five specific asanas designed to alleviate menstrual symptoms. This program was conducted five days a week, with each session lasting 40 minutes..EEG recordings were carried out during the 1st week, 12th week, and 24th week of the program using an 8-channel OpenBCI system for both groups. Power spectral density (PSD) analysis was performed for different frequency bands across various time bins in different brain lobes. A deep learning model was then employed to classify EEG patterns associated with pain intensity and relaxation states, enabling objective assessment of therapeutic outcomes. Participants’ subjective responses to the asana practice were also collected, and suitable statistical tests were performed as needed. The control group did not participate in any yoga practice.

Results: Power Spectral Density (PSD) analysis indicates an increase in alpha brainwave activity after six months of practicing yoga asanas. One of the deep learning techniques used, Bidirectional Long Short-Term Memory (BI-LSTM), demonstrated an impressive ability to accurately classify the signals as pain, normal, or yoga-related, achieving a high accuracy rate of 94.11%, which surpassed previous studies. Additionally, 91% of the participants reported a reduction in menstrual abdominal pain as well as associated psychological symptoms like anxiety and stress.

Conclusion: The integration of electroencephalographic evaluation with deep learning analysis provides an innovative framework to objectively quantify the therapeutic effects of Yoga Asanas in primary dysmenorrhea. This study’s findings indicate that yoga asanas can effectively reduce menstrual pain and enhance cognitive functions, as demonstrated through EEG PSD analysis and participant feedback. This suggests that yoga may serve as a viable alternative treatment for primary dysmenorrhea in young women.Further large-scale studies are warranted to validate these findings and refine predictive neuro-markers of therapeutic efficacy

Keywords: Dysmenorrhea, Yoga with asanas, Young Women, EEG, PSD, OPEN BCI, BI-LSTM

Biography

Dr. Anuradha has 20 years of Experience in Teaching, currently working as a Professor in the Department of Computer Science and Engineering at Sri Ramakrishna Engineering College. Have completed Ph.D. in the Research Area Data Mining (Fuzzy logic) and has a Master’s degree in Computer Science Engineering and a Bachelor’s degree in Computer Hardware and Software Engineering. SPOC of the Artificial Intelligence-Research Group and guided projects in the areas of Artificial Intelligence, Machine Learning, Cryptography and Data Analytics. Life member of ISTE, IEANG, & CSI and published Research papers in Scopus indexed Journals and Conferences. Awarded Silver Partner faculty under Inspire -The Campus Connect, Faculty Partnership Model, Infosys. Worked on consultancy projects with G.E Healthcare & LTTS (L&T technology) in the domain of medical image processing and deep learning. Convener of Artificial Intelligence Research Group at SREC and Lead person representing SREC at Leadingindia.ai, a nationwide initiative for artificial intelligence skilling and research-Bennett University, Noida. Worked on a TANSCST Funded project that involves Women Health with Brain Computer Interface and Yoga therapy.

Abstract

Women of all ages, starting from puberty, often encounter challenges related to premenstrual syndrome (PMS) and menstrual symptoms. These challenges can include abdominal pain and psychological effects such as stress and anxiety, which can significantly impact brain function. Primary dysmenorrhea, characterised by painful menstrual cramps without identifiable pelvic pathology, affects a significant proportion of women of reproductive age, often impairing quality of life and daily functioning. Non-pharmacological interventions such as Yoga Asanas have been increasingly recognised for their potential to modulate pain perception and improve physiological balance. However, the neurophysiological mechanisms underlying these effects remain inadequately explored.

Objectives: This study aims to assess the therapeutic impact of selected Yoga Asanas on primary dysmenorrhea in young women by evaluating neurophysiological responses using electroencephalographic (EEG) recordings and applying deep learning techniques for pattern classification.
This interventional study was conducted young female engineering college students aged 18 to 25, lasting for six months. Participants were selected for the intervention group and the control group after obtaining informed consent. The intervention group underwent a supervised 24-week yoga program, focusing on five specific asanas designed to alleviate menstrual symptoms. This program was conducted five days a week, with each session lasting 40 minutes..EEG recordings were carried out during the 1st week, 12th week, and 24th week of the program using an 8-channel OpenBCI system for both groups. Power spectral density (PSD) analysis was performed for different frequency bands across various time bins in different brain lobes. A deep learning model was then employed to classify EEG patterns associated with pain intensity and relaxation states, enabling objective assessment of therapeutic outcomes. Participants’ subjective responses to the asana practice were also collected, and suitable statistical tests were performed as needed. The control group did not participate in any yoga practice.

Results: Power Spectral Density (PSD) analysis indicates an increase in alpha brainwave activity after six months of practicing yoga asanas. One of the deep learning techniques used, Bidirectional Long Short-Term Memory (BI-LSTM), demonstrated an impressive ability to accurately classify the signals as pain, normal, or yoga-related, achieving a high accuracy rate of 94.11%, which surpassed previous studies. Additionally, 91% of the participants reported a reduction in menstrual abdominal pain as well as associated psychological symptoms like anxiety and stress.

Conclusion: The integration of electroencephalographic evaluation with deep learning analysis provides an innovative framework to objectively quantify the therapeutic effects of Yoga Asanas in primary dysmenorrhea. This study’s findings indicate that yoga asanas can effectively reduce menstrual pain and enhance cognitive functions, as demonstrated through EEG PSD analysis and participant feedback. This suggests that yoga may serve as a viable alternative treatment for primary dysmenorrhea in young women.Further large-scale studies are warranted to validate these findings and refine predictive neuro-markers of therapeutic efficacy

Keywords: Dysmenorrhea, Yoga with asanas, Young Women, EEG, PSD, OPEN BCI, BI-LSTM

Biography

Mrs. G. Rathi earned her Master of Engineering degree in Computer Science and Engineering from Anna University of Technology, Coimbatore, in 2012. She completed her Bachelor of Engineering degree in Computer Science and Engineering at Bannari Amman Institute of Technology, affiliated with Bharathiyar University, in 2002. With 18 years of teaching experience, her research interests encompass the Internet of Things (IoT), Cognitive and Computational Brain Science, and Business Intelligence. Currently, she is pursuing a Doctor of Philosophy degree at Anna University, Chennai. Mrs. Rathi has authored approximately 20 publications across various national and international journals and conferences. Awarded Silver Partner faculty under Inspire -The Campus Connect, Faculty Partnership Model, Infosys. Worked on consultancy projects with various industries. She holds lifetime membership in the Indian Society for Technical Education (ISTE) and the Computer Society of India (CSI), and is also a member of the International Association of Engineers (IAENG).Worked on a TANSCST Funded project that involves Women Health with Brain Computer Interface and Yoga therapy.

Abstract

As chronic diseases and stress-related conditions rise globally, the need for a preventive, patient-centred approach to health has never been more urgent. Integrative Medicine offers an effective model—uniting the precision of Western science with the depth and balance of Eastern healing traditions. In this session, Dr Cesar Daoud explores how these complementary systems can work together to restore harmony, strengthen resilience, and support longevity. Drawing on more than two decades of clinical experience, he demonstrates how ancient diagnostic principles and modern evidence-based practices can merge to address the physical, emotional, and energetic dimensions of well-being. Participants will gain practical insights into how Integrative Medicine can be applied in daily life to reduce inflammation, balance hormones, and optimise vitality—helping individuals not only treat illness but prevent it. This talk invites a redefinition of modern health—one that empowers individuals to take charge of their wellness journey through awareness, balance, and sustainable vitality.

Biography

Dr. Cesar Daoud, Doctor of Acupuncture & Traditional Chinese Medicine, Integrative Medicine, and Health & Longevity Expert, is the founder of Bioenergy, established in 2008. With over 21 years of international experience, he has helped thousands—from children to heads of state—restore balance, manage chronic conditions, and cultivate vitality through a unique blend of Eastern and Western medicine. Dr. Daoud received his academic and clinical training in Lebanon, France, and China, and pursued advanced studies in the Netherlands and the UK. His multidisciplinary background includes Acupuncture, Traditional Chinese Medicine, Physical Therapy, Posturology, Osteopathy, Qigong, Biopuncture, and Vitamin Therapy. Now based in Cyprus, Dr. Daoud integrates ancient healing wisdom with modern science to promote energy, longevity, and a pain-free life. Dr. Daoud is renowned for his expertise in chronic pain, women’s health, emotional balance, and hormonal and nervous system optimization, as well as for his guidance in stress management and resilience. A passionate Health & Longevity Lecturer, he inspires audiences to embrace an integrative, preventive approach—bridging tradition and innovation for lasting well-being.

Abstract

Background: Indigenous health has long been marginalised within biomedical systems, despite the persistence of traditional practices that address both physical and spiritual well-being. Among the Tenetehara-Tembé people of the Alto Rio Guamá Indigenous Land (TIARG), located in northeastern Pará (Eastern Amazonia), traditional healing practices continue to play a central role in community resilience, particularly during times of crisis such as the COVID-19 pandemic.
Objectives: This lecture seeks to analyse how the Tenetehara-Tembé conceptualise and practice healing in relation to morbidity, with a particular focus on the interplay between official medical systems and alternative Indigenous practices. A decolonial perspective is adopted to highlight Indigenous epistemologies of prevention and care.
Methods: Ethnographic engagement was carried out in the Zawara Uhu village, with attention to the roles of community leaders, midwives, and shamans in health-related practices. The study draws on lived experiences and narratives shared by the Tembé during and beyond the COVID-19 pandemic, situating these within broader discussions on Indigenous health and environmental transformations.
Results: Findings underscore that pandemics, such as COVID-19, reflect the consequences of negligent modernity and its impacts on ecosystems. The Tembé’s practices illustrate a holistic understanding of health—encompassing body and soul—and reveal alternative frameworks for disease prevention and healing. These practices are not merely cultural survivals but constitute adaptive strategies of resilience and citizenship in the face of ongoing social and environmental challenges.
Conclusion: The Tembé’s healing practices highlight the critical importance of Indigenous knowledge in confronting morbidities that arise both from modern illnesses and from the ecological crises of the civilizing process. By integrating traditional and alternative approaches to care, the Tembé demonstrate pathways toward more inclusive and sustainable health systems.

Keywords: Disease; Tembé; Morbidity; Healing Practices

Biography

José Augusto Carvalho de Araújo holds a PhD in Sociology from the Federal University of São Carlos (UFSCar-SP), where he also completed his postdoctoral studies. He earned a Master’s degree in Sociology from the Federal University of Paraíba (UFPB), a specialization in Political Science from the Federal University of Pará (UFPA/IUPERJ), and a Bachelor’s degree in Social Sciences from the University of the Amazon. Since 1993, he has served as a professor at the State University of Pará (UEPa), where he is currently Adjunct Professor with Full-Time and Exclusive Dedication (TIDE) and a permanent faculty member of the Graduate Program (stricto sensu) in Environmental Sciences. With 32 years of experience in higher education, his research and teaching focus on Sociology and Anthropology, with an emphasis on health and the environment.

Abstract

The Free State province in South Africa has become an epicenter for a novel form of violence wherein criminal youth gangs incorporate elements of African witchcraft and esoteric belief ideology into their gang practices. A vital component of these practices is the use of traditional African medicine or ‘muti’ which is comprised of plants, herbs and in extreme cases, human organs and blood, and is utilized to further coercive, ritualistic and violent purposes within gangs. Despite growing reports of muti-related rituals including organ harvesting, the consumption of human blood, and the use of paraphernalia believed to enhance invincibility, official crime statistics and empirical literature remain limited. Moreover, no studies in the region have been conducted directly exploring gang members’ perspectives and lived realities regarding how muti is conceptualized and used within the context of the gang. Grounded in subcultural and cultural transmission theory, this study draws on qualitative data to examine the symbolic, functional and ideological roles of muti in youth gangs in the Free State. Data were collected through semi-structured interviews with 23 active gang members, 16 non-gang-affiliated offenders and 18 criminal justice professionals, and analysed using reflexive thematic analysis. The findings revealed that muti is not merely a symbolic tool but is embedded in gang initiation rites, hierarchy, identity, ideology and violence. Gang members believed muti to be a means of acquiring supernatural protection and enhance spiritual power, instilling fear, and affirming loyalty to the gang. The manipulation of muti for criminal gain represents a distinct departure from conventional gang norms and signals a broader spiritualisation of gang identity in the province, while simultaneously perpetuating illegal organ harvesting and trade within the region. This study offers a unique contribution to gang scholarship by documenting how indigenous belief systems are appropriated and weaponised in youth criminal subcultures. Moreover, the study provides critical insights for the development of culturally informed intervention strategies, particularly in contexts where traditional spirituality intersects with organised violence.
Keywords: occult-gang, youth gang, typology, witchcraft, devil worship, ritual, muti , demon.

Biography

Dr Ashwill Ramon Phillips is a Lecturer in the Department of Criminology at the University of the Free State, South Africa. He holds a PhD in Criminology and specializes in youth deviance, gang subcultures, and criminogenic risk trajectories. His research focuses on the socio-cultural dynamics of youth gangs, including the intersection of gang identity with occult practices and symbolic violence. Dr Phillips has published and presented extensively on pathways to youth misconduct, resilience, and the formation of deviant identities. His work is rooted in qualitative and reflexive methodologies, and he is committed to advancing criminological knowledge that informs both theory and practice. Dr Phillips is also actively involved in curriculum development, postgraduate supervision, and community engagement initiatives with the Department of Correctional Services.

Abstract

Nutraceuticals are the substances that derived from food sources with additional health benefits in addition to the basic nutritional value. It is well known that many compounds of plant origin can ameliorate various patho-physiological conditions. Reactive Oxygen Species and free radicals are the key factors associated with oxidative stress that induce cell damage by interfering the biomolecules including DNA. Any molecule/s that can scavenge the free radicals have a potential to use as a nutraceutical.

While screening the nutraceutical potential of algae we could isolate two algae Asterarcys quadricellulare and Scenedesmus vacuolatus and found that it produced a variety of pigments. It was identified that A. quadricellulare produced b-carotene, astexanthin, lutein and canthaxanthin under nutrient limited cultural conditions. These pigments were subjected for bioassay and noticed that it possessed in vitro free radical scavenging property, cytotoxicity on HeLa and Ht29 cell lines as well as anti-inflammatory property on RAW 264.7 macrophage cell lines by inhibiting the action of inflammatory mediators like COX, LOX, MPO and iNOS and reducing cellular nitrite level. The aplanospores of S. vacuolatus accumulated canthaxanthin, b-carotene, astaxanthin and lutein under Nitrogen-limited conditions in a two-stage cultivation system. These pigments were subjected for bioassay and found that they possessed cytotoxic property on HeLa and HT-29 cell lines. These results indicated the nutraceutical potential of A. quadricellulare and S. vacuolatus.

Our laboratory also conducted diverse study on phytochemicals of plant origin. The plant one which we focused was C. papaya. A preliminary study of the flavonoids of this plant showed that it possessed a variety of nutraceutical potential. Hence, we standardized the methodology for isolating its flavonoid fractions from the leaf further fractionating with HPTLC, identifying flavonoids through UPLC-Q-ToF-MS/MS analysis, quantification by HPLC and evaluating free radical scavenging potential using DPPH and FRAP assays.

The Flavonoid rich fraction and HPTLC separated fractions were characterized via UPLC-Q-ToF-MS/MS analysis and identified 11 flavonoids with 4 new ones. HPLC quantification revealed that mauritianin is one of the major flavonoids in FFCP, with its yield being twofold higher compared to previous reports. Flavonoid rich fraction exhibited significant free radical scavenging and metal-reducing property. The antioxidant activity of the HPTLC fractions of FFCP showed that the quercetin and its derivative-containing fraction (B3) exhibited superior antioxidant activity compared to the fraction containing kaempferol and its derivatives.

The in-vitro investigation demonstrated that the flavonoid fraction of exerts cytoprotective effects on human erythrocytes and peripheral blood mononuclear cells (PBMCs). It was ascertained by SEM, H2O2 induced oxidative damages such as lipid peroxidation, LDH leakage, DNA damages, effectively reduced intracellular ROS production and calcium mobilization. The efficacy was ascertained by increased the activity of antioxidant enzymes, upregulated Nrf2 gene expression and its nuclear translocation. ADMET and drug likeness prediction showed that all flavonoids have good ADME and drug likeness score to develop as a potential drug against oxidative stress associated diseases. Flavonoid rich fraction inhibited the activity of key inflammatory enzymes namely COX, LOX, and iNOS responsible for the production of proinflammatory markers such as prostaglandins, leukotrienes, and nitric oxide. Additionally, the fraction downregulated the expression of the NF-κB transcription factor and the subsequent production of pro-inflammatory markers such as TNF-α, IL-6, and IL-1β in LPS induced cells.
These studies revealing the potential of algal pigments obtained from two algae and flavonoids of plant origin have nutraceutical value to ameliorate the consequences of free radical medicated damages.

Biography

Prof. Krishnakumar. K, PhD in Biochemistry, currently working as a Professor in Department of Botany, Maharaja’s College, supervising research students in the field of nutraceuticals, published more than 25 research articles in the field of nutraceuticals, presented papers in national and international seminars, 25 years of teaching Botany.

Abstract

Autoimmune diseases, characterized by the immune system’s erroneous attack on the body’s own cells, present a complex pathophysiological challenge, often necessitating a comprehensive and integrative treatment strategy. The current emerging complementary therapies, such as Siddha and energy healing, offer a holistic approach to restoring immune balance by addressing both the underlying causes and symptomatic manifestations of autoimmune disorders. Crohn’s disease (CD), a chronic autoimmune disorder affecting the gastrointestinal tract, is characterized by inflammation, abdominal pain, diarrhea, weight loss, and malabsorption. Conventional treatments involve immunosuppressants, biologics, and surgery, but chances for relapse of the system are always present. Many patients seek complementary therapies to manage symptoms and improve quality of life in such conditions.

According to Siddha principles, Crohn’s is caused by an imbalance in the three humors (Vatham, Pitham, and Kapham), primarily Pitha aggravation, leading to chronic intestinal inflammation. Traditional Siddha medicine offers a holistic and integrative approach in managing Crohn’s disease, focusing on restoring immune balance, reducing inflammation, and healing the gut. This study presents two cases of Crohn’s disease successfully managed at Chakrasiddh, demonstrating significant clinical improvement through Siddha-based therapy, energy healing, and dietary modifications. Both cases exhibited marked improvements in laboratory biomarkers, symptomatic relief, and colonoscopic findings following treatment. Pre and post-therapy assessments, including biochemical parameters, inflammatory markers, and endoscopic evaluations, provide objective evidence of the therapeutic efficacy of this integrative approach. These findings highlight the potential role of Siddha therapies in complementing conventional treatments for autoimmune gastrointestinal disorders like Crohn’s disease, promoting both symptomatic relief and mucosal healing.

Biography

Dr. Sathya Sindhuja, a renowned 36th-generation Siddha healing practitioner, brings over 35 years of expertise in holistic wellness, having successfully treated nearly 100,000 patients worldwide. As the Founder and Director of Chakrasiddh Holistic Centre, she seamlessly integrates Siddha therapies with customized energy healing sessions, fostering profound remedials and balance. Recognized as a divine healer and esteemed astrologer, Dr. Sindhuja possesses the unique ability to read auras, offering insights into both past influences and future well-being. Her exceptional healing practices have garnered international recognition, attracting patients from around the globe. A dedicated philanthropist, she extends free treatments to the underprivileged, exemplifying her unwavering commitment to public welfare and holistic care. She has also served distinguished dignitaries, Telugu celebrities, and prominent personalities, earning widespread admiration. With a specialized focus on women’s health, mind-body interactions, and dietary wellness, Dr. Sindhuja has contributed extensively to the academic and medical communities, authoring 30 peer-reviewed articles and delivering numerous public lectures. Her contributions have been honored with prestigious accolades, including the Times Group’s Icon in Siddha Vaidyam Award and the Dr. A.P.J. Abdul Kalam Award for Ancient Siddha Therapy. Through her compassionate care, groundbreaking research, and holistic healing approach, Dr. Sathya Sindhuja continues to pioneer the global advancement of Siddha medicine, transforming lives and shaping the future of integrative healthcare.

Abstract

India is fast becoming an active hub neutraceuticals and is poised to take off to a higher trajectory of growth potential by 2030 reach to a 100 billion dollar industry* from the current growth rate of over 26 percent. It was during the Covid 19 pandemic the growth stabilized from 10 percent to over 16 percent and the shift is still positive. The holistic change was admittedly due to an increase in the wide number of Indians consuming basic nutraceuticals during the pandemic. It was during the pandemic period the Indian community woke up to fuel the growth and touch the present growth from an early meager rate of around ten percent.
It is a fact that the medicinal farming sector is vibrant in its 52 Agro-climatic zones with about 1700 medicinal plants and with the aid of IT applications, the environment is acting as a driving force for raw material supply chain for nutraceutical products. Besides, India has become a focus of vast number of world-class GMP facilities in the Formulation ecosystem and could proudly be termed as having the largest FDA-approved contract manufacturing facilities in the world with additional high-end nutraceutical manufacturing facilities. In fact, India has become a global contract manufacturing hub in nutraceuticals. Further, it is stated that the Start-up ecosystem in India is having around 7500 nutraceutical start-ups embracing latest technological transformation taking place across the entire ecosystem.
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*Survey Conducted by Nutrify Today*
One of the major issues that were currently faced was a lack of awareness among the consumers. The differentiated responsible nutraceutical portfolios need to be drawn up along with clinical validation outcomes. At the current pace and trend, India is likely to offer wealth of opportunities for the nutraceutical industry outside the USA.
From 2021 onwards, Immune health has become synonymous with maintaining a healthy lifestyle. However, except few products related to Black Pepper, Turmeric, Ginger, Fenugreek, Saffron, Pomegranate and few others, there has been a lack of innovation within the Immune Health category. In the wake of a turbulent Covid 2020, consumers are more focused on taking care of their health and are looking for safe, transparent, quality solutions focusing mainly to botanical and herbal solutions.
The emergence of nanotechnology has also changed the face of the booming nutraceuticals in India as well. New technologies like water dispersion technology, The use of Polar-Non-polar Sandwich (PNS) technology, The Hydroalcoholic extraction have also changed the face of nutraceutical industry in India.
New horizons that will contribute to advanced research in the field of Spices primarily leading to have detox potential, strategic nutrition for organ health and holistic health solutions have to be focused upon, including well designed Clinical Studies on a pharma level.

Biography

Dr. M P Suresh is a multi-disciplinary academic post-graduate and Doctoral Degree holder from World-class Madras University, across his career in Spices Board of India, he has handled myriad roles as Editor and Deputy Marketing Director and gained insightful experience in Marketing, Export Promotion, New Product Development, Quality and Safety of spices and spice products spanning over three decades. He gained hands on experience in policy formulation related to marketing, export promotion and export development including market access initiative projects in overseas markets, up-gradation of technology, and organised several National and International Seminars and Buyer-seller meets of Spices Board. Besides a Master trainer and Resource Person for various programmes on marketing and post-harvest improvement of spices, he presented several Papers in National and International Conference, Seminars and Workshops. He had also officiated as Chief Rapporteur in International Conferences including that organised by FAO and WHO.
Suresh has gained rich cross-cultural experience from his travel to Saudi Arabia, Malaysia, Singapore, USA, Brazil, China, Tokyo, UAE and Bahrain.
He has been teaching at prestigious universities like IGNOU, Government of India and Pondicherry University as a Senior Guest Faulty over the last 35 years in multi-disciplinary subjects at Bachelor and Master Level and as a media personnel, he did programmes over Television and also covered national and international events for print media with credit for over 300 articles in leading English publications on a variety of topics. He is a recipient of Fellowship of UNDP.

Abstract

Aedes aegypti (Linnaeus, 1762) is one of the most medically important mosquitoes because it is a vector of different arboviruses in urban areas, such as dengue, chikungunya and zika. The use of synthetic topical repellent based on N,N-diethyl-3-methylbenzamide (DEET) is one of the main methods of protection against the vector. However, studies show that mosquitoes have been showing resistance to the repellent action of DEET, which demonstrates the importance of alternative topical repellents, such as those based on essential oils (EOs). Among plant species that synthesize EOs is Croton sp. In this sense, the objective was to evaluate the in vitro topical repellent activity of the EO from Croton sp leaves against Ae. aegypti. For the test, mated female mosquitoes up to ten days old were used. Firstly, we sought to estimate two effective concentrations to repel 50 and 99% of mosquitoes from concentrations of 125; 100; 75; 50 and 25 mg/cm2 formulated in non-ionic emulsion. Each concentration was evaluated as follows: with 50 mosquitoes in the cage, five areas of 4.9 cm2 were marked on the upper part. A quantity of 0.1 g of the formulation initially containing the lowest concentration was applied to one of the markings. Subsequently, an artificial feeder containing 1 mL of blood from Capra aegagrus hircus (Linnaeus, 1758) preheated to 37 °C was placed over each concentration for three minutes (For the use of blood, the project was approved under registration 23076.058811/2020). The evaluation criterion was the number of landings. Next, the protection time of the 99% effective repellent concentration was evaluated. The same materials described above were used for the test. However, the evaluations were as follows: After 30 minutes of applying the 99% effective concentration, the artificial feeder was placed over the concentration for three minutes. Afterwards, the feeder was removed and placed in a water bath until the next evaluation, which occurred at 30-minute intervals, until 360 minutes were completed. The evaluation criteria were landings and blood feeding. The results showed that to repel 50 and 99% of mosquitoes, the estimated concentrations were 3 and 109 mg/cm2, respectively. The concentration of 109 mg/cm2 offered 64.8% protection against landings in 360 minutes and 100% against blood feeding for 150 minutes. The results indicate that Croton sp leaf EO is a promising alternative topical repellent in protection against the mosquito Ae. aegypti.

Biography

Prof. Janaina Freitas holds a degree in Biological Sciences (Licentiate and Bachelor’s) from the State University of Paraíba (UEPB, 2003) and a Ph.D. in Biochemistry from the Ribeirão Preto Medical School – University of São Paulo (FMRP-USP, 2008). Currently is a Full Professor at the State University of Southwest Bahia (UESB), teaching in the Chemistry, Environmental Engineering, Food Engineering, Animal Science, and Biological Sciences programs.

Currently is a permanent member of the Graduate Program in Environmental Sciences (PPGCA) and serves as the Local Coordinator of the Multicenter Program in Biochemistry and Molecular Biology (PMBqBM). Her research focuses on microbial metabolism and genetics, as well as biotechnology, particularly in fermentation processes for bioproduct production. She collaborates with the Innovation and Biotechnology Laboratory (InBiotec).

Abstract

SKY is increasingly gaining recognition as a means to relieve occupational stress and burnout especially in high-stress environments. The controlled breathing patterns of SKY are meant to bring about the relaxing effect, emotional regulation, and general improvement in employees’ mental well-being.
Research has shown that SKY can significantly reduce the levels of stress and elevate psychological well-being among professionals. For example, a randomized control trial with medical doctors showed a significant decrease in psychological distress and burnout among participants participating in a SKY program against those who just received standard training on stress management (Korkmaz, 2024). This is specifically relevant because doctors and other professionals in the healthcare line experience high rates of stress and burnout and this can worsen their effectiveness and well-being (Korkmaz, 2024). The study demonstrates the viability of applying SKY as a non-pharmacological intervention in boosting resilience and coping in high-stress occupations.
Additionally, the physiological aspects of SKY contribute to its effectiveness in handling workplace stress. The exercise is known to enhance vagal tone, associated with improved emotional regulation and decreased reactivity to stress (Parimala & Kanchibhotla, 2020; Goldstein et al., 2016). This physiological response is essential for individuals working in stressful work environments, as it may result in effective stress management and reduced anxiety levels (Parimala & Kanchibhotla, 2020). SKY has also been associated with enhanced cognitive functioning and attention, which are necessary for keeping one’s productivity and concentration in the workplace (Chandra et al., 2016; Kopańska et al., 2022).
Besides these, the effectiveness of SKY in reducing burnout is complemented by the fact that it instills a feeling of community and social support in practitioners. Practice in group sessions of SKY can enhance the sense of social connection, a protective factor for burnout, as indicated by Vasudev et al. (2022). This sense of community provides both emotional support and stimulates the sharing of coping strategies at work, therefore creating a work environment that fosters support.
There is a potential positive effect of integrating SKY into workplace wellness programs. Organizations that adopt SKY as part of their employee wellness initiatives have reported improvement in employee satisfaction, reduced absenteeism, and overall workplace morale (Bhaskar et al., 2020). These outcomes suggest the potential for SKY as a holistic approach to managing workplace stress and preventing burnout.
In conclusion, Sudarshan Kriya Yoga offers a multifaceted approach to addressing workplace stress and burnout. Its effectiveness in reducing psychological distress, enhancing emotional regulation, and fostering social support makes it a valuable intervention for individuals in high-stress occupations. Continued research and implementation of SKY in workplace settings could provide significant benefits for employee well-being and organizational health.

Biography

Dr. Monika Pathania is an accomplished medical professional serving as an Additional Professor in the Department of Medicine at the All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand. She has also held key administrative roles as Ex-Associate Dean (Research) and Ex-Assistant Dean (Student Welfare) at the institute. With a distinguished academic background, including an MD in Internal Medicine and certifications in Lifestyle Medicine (IBLM, ASLM, ISLM), Dr. Pathania has significantly contributed to healthcare innovation. She pioneered the institute’s first “Lifestyle Disease Clinic” and later expanded it into an Integrative Medicine Clinic and a Professional Burnout and Well-Being Clinic. Her research portfolio includes 112 publications and 18 projects. She is a DFID fellow in diabetes from CMC Vellore and a board-certified lifestyle medicine physician. Additionally, she is a certified yoga instructor under AYUSH (200 hours) and SSY. Dr. Pathania’s excellence has been recognized with several prestigious awards, including the Outstanding Woman Researcher in Internal Medicine Award (VIWA 2024), Excellence in Research of the Year Award (DISTF-2023), and Best Teacher Award (2018). She has also received accolades for her presentations at national conferences and achievements in yoga competitions.

Abstract

Anuloma Viloma Pranayama (AVP), also known as Alternate Nostril Breathing (ANB), is a widely practiced pranayama technique known for its regulatory effects on cardiovascular and brain activity. This study aimed to explore the simultaneous effects of AVP on heart rate variability (HRV) and brain wave activity in a cohort of 30 healthy volunteers practicing kriya yoga for over 15 years. The study was conducted from October to December 2021. ECG for HRV analysis and EEG recordings for brain wave spectrum analysis were collected during three phases: pre-AVP, during AVP, and post-AVP, each lasting five minutes.
Statistical analysis using repeated measures of analysis of variance (ANOVA) with Bonferroni and Holm’s post-hoc comparisons showed significant increases in time-domain HRV parameters (SDNN and RMSSD) during AVP compared to pre- and post-AVP. In frequency-domain analysis, total power, LF power, HF power, and LF/HF ratio also showed significant increases during AVP, with the LF/HF ratio remaining elevated post-AVP. EEG recordings revealed a significant rise in Alpha, Beta, and Gamma wave power during AVP compared to baseline and post-AVP phases. These findings suggest that the lungs, heart, and brain act as coupled oscillators, and AVP induces an aroused, attentive state without significantly affecting heart rate, while enhancing overall HRV.

Biography

Dr. Varun, MD, DNB, MNAMS, holds a diploma in Naturopathy and Yoga and has been a regular faculty member at several institutions. He previously served as a Professor and Head of the Department at Santosh Medical College and is currently an Additional Professor in the Department of Physiology at AIIMS Bhopal. With 22 years of experience, his research interests include Medical Education and Mind-Body Medicine. Dr. Varun conducts yoga and meditation sessions for students and staff and enjoys sharing his passion for physiology. He has received multiple awards, including the prestigious Shri Ram Murthy, VIHA, and ISSN awards.

Abstract

Unrelenting neuropathic pain presents challenges in diagnoses and treatment. The International Association for the Study of Pain (IASP) defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system.” The injury or disease may occur in the peripheral or central nervous system giving rise to painful conditions such as post herpetic neuralgia, painful diabetic neuropathy, post amputation pain, complex regional pain syndrome, trigeminal neuralgia, post stroke pain, and pain after spinal cord injury, to name a few. These patients are frequently disabled from severe pain, have poor quality of life, and suffer from anxiety, depression and sleep problems. They often strain the healthcare system with frequent visits. Treatment of neuropathic pain can be challenging, often exhausting conventional approaches. A multimodal approach integrating pharmacological, interventional and integrative modalities may be helpful. This talk will cover a brief review on the pathophysiology of pain and focus on interventions that specifically target neuropathic pain, such as neuromodulation, including peripheral nerve stimulation and infusions using ketamine.

Biography

Dr. Chin is Professor Emeritus of Anesthesiology and Critical Care Medicine at the George Washington (GW) University, Washington DC. She served as Director of the GW Pain Medicine Fellowship Program and Co Director of the GW Spine and Pain Center. Dr. Chin earned her medical degree at the University of Melbourne, Australia. Her interests include innovative pharmacological, interventional and neuromodulatory techniques for management of chronic neuropathic pain. She has published on topics in pain medicine including pain in women, written numerous articles and authored book chapters on both acute and chronic pain. She served on the American Society of Anesthesiologists (ASA) Pain Medicine Committee, the American Medical Association (AMA) advisory board for pain, the Anesthesia and Analgesia (A&A) Editorial board as a reviewer, and the American Board of Anesthesiologists (ABA) as an associate board examiner. She has presented and lectured on acute and chronic pain at national meetings including the ASA, the American Society of Regional Anesthesia and Pain Medicine and the American Academy of Pain Medicine. For the past twenty years she was consistently listed in Washington Top Docs for Pain Medicine and was recently awarded the Trailblazer Award from ASRA.