Dr. Shumei Song is a Professor at the Coriell Institute for Medical Research in Camden, New Jersey, and the Director of Translational GI Research at MD Anderson Cancer Center at Cooper, Cooper University Hospital, Camden, New Jersey. She received her Ph.D. in Molecular Biology and Biochemistry from the Beijing Cancer Institute, Peking University, China, where her graduate work focused on cloning and elucidating the functional role of the VEGF receptor KDR in tumor angiogenesis and metastases in gastric cancer. After obtaining her Ph.D. in 1999, she pursued a postdoctoral fellowship at UT MD Anderson Cancer Center in Houston, where she focused on cancer biology in gastrointestinal cancers, particularly in the esophagus and the gastroesophageal (GE) junction, the area where the esophagus joins the stomach, as well as in gastric cancer. She has been gained extensive experience in gastrointestinal cancer biology, gene transcription and expression regulation, and molecular approaches to investigating the mechanisms underlying the initiation, progression, and metastasis of GE junction and gastric cancers. As an independent investigator, her laboratory and team are dedicated to understanding the molecular mechanisms and identifying novel therapeutic targets, with a focus on how deregulation of Hippo/YAP signaling mediates cancer stem cell traits, therapy resistance, and metastases in gastroesophageal cancers. One of the primary projects in her laboratory aims to decipher how Hippo/YAP/TAZ signaling and other stem cell factors, such as SOXs, mediate immunosuppressive tumor microenvironments. This includes investigating the interactions among tumor cells, macrophages, cancer-associated fibroblasts (CAFs), and T cells to develop novel therapeutic strategies. Her long-term goal is to develop YAP1/TAZ/TEAD inhibitors for the targeted therapy of gastrointestinal cancers and to discover innovative immunotherapy approaches for advanced GI tumors by utilizing patient-derived tissues and cells.
Before joining the Coriell Institute, Dr. Song was a Professor in the Department of Gastrointestinal Medical Oncology at the University of MD Anderson Cancer Center in Houston, Texas, where she focused on GI cancer research for over 20 years.