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Title : Synchronous Bilateral Papillary Renal Cell Carcinoma in Native Kidneys 10 Years After Renal Transplantation: A Case Report and Literature Review
Name : Haytham Araibi
University : Department of Urology
Country : United Kingdom
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Renal transplantation significantly improves survival and quality of life in patients with end-stage renal disease; however, it is associated with an increased risk of malignancy, particularly in native kidneys. The incidence of renal cell carcinoma (RCC) in transplant recipients is reported to be up to 15-fold higher than in the general population, often linked to long-term immunosuppression and acquired cystic kidney disease. We present the case of a 48-year-old male who underwent living donor renal transplantation 10 years prior and was maintained on immunosuppressive therapy. During routine follow-up, computed tomography imaging (page 2) revealed bilateral cystic renal lesions with enhancing solid components, consistent with multifocal renal masses. No distant metastases were identified. The patient underwent bilateral radical nephrectomy with preservation of the functioning graft. Histopathological examination demonstrated bilateral multifocal papillary renal cell carcinoma, Fuhrman grade 1–2, staged as T1aN1M0, with no lymphovascular invasion or sarcomatoid features. Follow-up over 36 months showed no evidence of recurrence or disease progression. This case highlights the increased risk of synchronous bilateral RCC in native kidneys of renal transplant recipients and emphasises the role of acquired cystic kidney disease as a key predisposing factor. Regular surveillance using imaging modalities is essential for early detection. Surgical management remains the mainstay of treatment, with favourable outcomes when diagnosed at an early stage.
Biography:
Dr. Haytham Araibi is a urology specialist with over 13 years of experience in general surgery and urology, with a particular interest in transplant urology, oncology, and minimally invasive surgery. He currently works as a Specialty Doctor in Urology in the United Kingdom and previously served as a Senior Clinical Fellow in Transplant and Renal Surgery at Guy’s Hospital, London. He holds an MD in Urology and master’s degrees in Medical Education and Human Morphology and Anatomy. Dr. Araibi is a member of the Royal College of Surgeons of Ireland and has multiple peer-reviewed publications in urology, including studies on transplant-related malignancies and complex surgical cases.
Title : Comparison of Mean Platelet Component and Mean Platelet Mass in Immune Thrombocytopenia Versus Hypoproductive Thrombocytopenias
Name : Mala Varma
University : Mount Sinai Health System
Country : USA
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Introduction: The Siemens (Bayer) ADVIA 120 has the capacity to calculate the mean platelet component (MPC), a measure of platelet density, and the mean platelet mass (MPM). In September 2013, we initiated a prospective study to determine if the MPC and MPM are significantly higher in immune thrombocytopenia than in hypoproductive thrombocytopenias. Methods: Lavender tri-potassium EDTA tubes were filled and analyzed on the Siemens (Bayer) ADVIA 120 within a period not exceeding two hours from their collection. The student’s t-test was used to compare these parameters in the patient groups. Coefficients of variation were used to study intra-individual variability and inter-individual variability. Results:Twenty patients with immune thrombocytopenia and 20 patients with hypoproductive thrombocytopenias were enrolled. The MPC and MPM were significantly higher in immune thrombocytopenia than in hypoproductive thrombocytopenias. A unique patient was studied when he had immune thrombocytopenia and then when he had chemotherapy-induced thrombocytopenia during treatment of lymphoma. His MPC and MPM were significantly higher during immune thrombocytopenia than during chemotherapy-induced thrombocytopenia. Intra-individual variability and inter-individual variability were low in this study. Conclusion: A strength of our study is that the MPC and MPM assays were measured within 2 hours of collection, since the MPC decreases over time. Our results attest to the clinical utility of MPC and MPM toward distinguishing immune thrombocytopenia from hypoproductive thrombocytopenias.
Biography:
Dr. Mala Varma is an Assistant Clinical Professor of Medicine at the Icahn School of Medicine at Mount Sinai, New York, USA. She has research interests in platelet and coagulation disorders. She has developed original studies for the treatment of immune thrombocytopenia and immune thrombotic thrombocytopenic purpura with danazol: Varma M, Shapira I, Friedman M, Nakhoul I, Torri V, Shulman J, Kozuch P, Culliney B, Patel AA, Yoe J, Shah VP, Mirzoyev T, Machuca M. Danazol and cost-savings in immune thrombocytopenia and in immune thrombotic thrombocytopenic purpura. Blood Coagul Fibrinolysis. 2025 Dec 1;36(8):388-390.
Title : In silico of Jatropha Gossypiifolia-derived Compounds Against Breast Cancer Targeting PR, p130Cas and hERα using Molecular Docking, DFT, MM-GBSA, and Molecular Dynamics Simulations
Name : Emmanuel Kitete Mulongo
University : University of Kinshas
Country : Congo
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Title : Novel Immunodominant Neoepitope in a KPC Mouse Model of Pancreatic Cancer Allowing Identification of Tumor-specific T Cells
Name : Ines Grazina de Matos
University : Roche Innovation Center Zurich
Country : Switzerland
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Title : Arts in Medicine for the Reduction of Pain and Stress in Cancer Patients During Chemotherapy
Name : Valerie J Kelley
University : Orlando Health Cancer Institute
Country : USA
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Title : B-cell Lymphoblastic Lymphoma Patient Presenting with Life-Threatening Ruptured Mycotic Aneurysm of the Internal Iliac Artery
Name : Mariam Malik
University : Consultant Radiologist Al Hilal Hospital
Country : Bahrain
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Title : The Role of Gut-Breast Axis during Critical Development Prenatal Period in Prevention of Breast Cancer by Epigenetic and Immune Regulation
Name : Chantal Matar
University : University of Ottawa
Country : Canada
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Title : Diagnostic Accuracy of DSC MRI Brain Perfusion Imaging in Differentiating Radiation Necrosis from Disease Progression in Early Postoperative Period
Name : Mariam Malik
University : Consultant Radiologist Al Hilal Hospital
Country : Bahrain
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Title : Improving the Accuracy of Reporting Ki-67 IHC by using an AI Tool
Name : Sahil Ajit Saraf
University : V G Saraf Memorial Hospital
Country : India
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Title : Evaluating the Effects of Curcumin Nano-chitosan on MiR-221 and MiR-222 Expression and Wnt/β-catenin Pathways in MCF- 7, MDA-MB-231 and SKBR3 Cell Lines
Name : Vida Mirzaie
University : Anatomy in Kerman University of Medical Sciences
Country : Iran
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Title : Cessation of Dormancy Involves an Increase of the Expression of TGFβ1 at Protein Level in Breast Cancer
Name : Maria Kristiina joensuu
University : University of Helsinki
Country : Finland
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Title : Atypical Spindle Cell/Pleomorphic Lipomatous Tumors
Name : Amir Qorbani
University : University of California San Francisco
Country : USA
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Title : Skin Metastasis Revealing Lung Carcinoma
Name : Abdelkader Sqalli Houssaini
University : National Institute of Oncology
Country : Morocco
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Title : Therapeutic Effect of MicroRNA‑21 on Differentially Expressed Hub Genes in Gastric Cancer Based on Systems Biology
Name : Hesam Ghafouri Kalajahi
University : Koc University
Country : Turkey
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Title : The Clinical Progression of Patients with Glioblastoma
Name : John E. Waneb
University : Barrow Neurological Institute
Country : USA
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Title : Hematological, Clinical, Cytogenetic and Molecular Profiles of Confirmed Chronic Myeloid Leukemia Patients at Presentation at a Tertiary Care Teaching Hospital in Addis Ababa, Ethiopia: A Cross-sectional Study
Name : Fekadu Urgessa Fita
University : Addis Ababa University, Addis Ababa
Country : Ethiopia
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Title : Pseudotumor Pulmonary Sarcoidosis: A Case Report
Name : Abir Bouhamdi
University : Sidi Mohamed Ben Abdellah University
Country : Morocco
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Title : RORγt and T-bet Expressions, Clinicopathological Indices and Survival Rate in Oral Squamous Cell Carcinoma Patients
Name : Maryam Ghelichli
University : Golestan University of Medical Sciences
Country : Iran
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Title : The Peritoneal Cancer Index as a Predictor of Completeness of Cytoreduction at Primary and Interval Cytoreductive Surgery in Advanced Ovarian Cancer
Name : Paula Josephine Fagan
University : St. George’s University Hospitals
Country : United Kingdom
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Title : “You Feel Different in your Body”: Experiences of Fatigue Among Children Undergoing Radiotherapy for Cancer Treatment
Name : Jessy Thambiraj
University : Charles Darwin University
Country : Australia
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Title : American Indian Cancer Epidemiology: An Oklahoma Experience
Name : Janis E. Campbell
University : The University of Oklahoma Health Sciences
Country : USA
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Title : The Efficacy of Neoadjuvant Chemotherapy as Compared to Upfront Surgery for the Management of Oral Squamous Cell Carcinoma- A Systematic Review and Meta-analysis
Name : Varthangpuii Varte
University : Govt Dental College and Hospital
Country : India
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Title : Facial Tumor in an Indigenous Child from the Brazilian AmazonDr
Name : Adryadne da Silva Adolfs
University : Federal University of Amazonas
Country : Brazil
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Title : The First-In-Class Radio enhancer NBTXR3: from Cancer Cell Destruction to Antitumor Immune Response Activation
Name : Sebastien Paris
University : Nanobiotix – Translational Science department
Country : France
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Title : Liquid Biopsy is useful to Find Cancer Clonal Changes and to Develop Personalized Cancer Immunotherapy
Name : Junichi Taguchi
University : Center for Advanced Medical Science and Technology
Country : Japan
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