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Title : Phytochemical Investigation of Naturally Occurring Compounds from Musanga Cecropioides R.Br. Ex Ted (Urticaceae) and Evaluation of their Anticancer and Antibacterial Activities
Name : Thabang Mphahlelea
University : University of Johannesburg
Country : South Africa
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Musanga cecropioides, commonly known as African corkwood, was studied for its phytochemical composition and antibacterial properties. Stem bark extracts were prepared using a dichloromethane-methanol mixture and subjected to chromatographic techniques, including column chromatography and thin-layer chromatography for compound isolation. Six known bioactive compounds were successfully isolated and identified: three sterols, stigmasterol (1), cupreol (2), and daucosterol (3), and three pentacyclic triterpenoids, friedelin (4), oleanolic acid (5), and betulinic acid (6). Structural elucidation was accomplished through spectroscopic analysis using one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), Fourier-transform infrared (FTIR) spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS). Spectral data were cross-referenced with literature reports to confirm compound identities. The antibacterial efficacy of the isolated compounds and crude extract was assessed using the microdilution method against twelve bacterial strains. Among these, Bacillus subtilis and Klebsiella aerogenes were the most susceptible. Most isolated compounds exhibited minimum inhibitory concentrations (MICs) of 18.5 µg/mL against these bacterial strains. However, friedelin (4) was significantly less active, with an MIC of 294 µg/mL against Klebsiella aerogenes. Of particular note, oleanolic acid (5) displayed the highest antibacterial potency, outperforming three standard antibiotics in activity against certain bacterial strains. This study provides new insights into the chemical constituents of Musanga cecropioides, marking the first report of stigmasterol, cupreol, daucosterol, friedelin, and betulinic acid being isolated from this species. The findings highlight the considerable antibacterial potential of these natural compounds, positioning Musanga cecropioides as a promising source for novel antibacterial agents. Further research may explore its therapeutic applications and contribute to the development of plant-derived antimicrobials.
Keywords: Musanga cecropioides, antibacterial activity, sterols, pentacyclic triterpenoids, Klebsiella aerogenes
Biography
Mr. Thabang Mphahlele began his academic journey in 2017 with a Diploma in Analytical Chemistry from the University of Johannesburg (UJ), graduating in 2021. He completed an Advanced Diploma in 2022 and earned his BSc Honours in Chemistry the same year. He is currently pursuing an MSc in Chemistry under Prof. Derek Ndinteh at UJ’s Drug Discovery and Smart Molecules Research Laboratory. A member of the Centre for Natural Product Research, Mr. Mphahlele is a dedicated young researcher with a manuscript ready for publication and a strong interest in drug discovery and natural product chemistry.
Title : Nutraceuticals that Influence Oxidative Stress, Inflammation and Gene Regulation
Name : Krishnakumar. K
University : Maharaja’s College
Country : India
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Nutraceuticals are the substances that derived from food sources with additional health benefits in addition to the basic nutritional value. It is well known that many compounds of plant origin can ameliorate various patho-physiological conditions. Reactive Oxygen Species and free radicals are the key factors associated with oxidative stress that induce cell damage by interfering the biomolecules including DNA. Any molecule/s that can scavenge the free radicals have a potential to use as a nutraceutical.
While screening the nutraceutical potential of algae we could isolate two algae Asterarcys quadricellulare and Scenedesmus vacuolatus and found that it produced a variety of pigments. It was identified that A. quadricellulare produced b-carotene, astexanthin, lutein and canthaxanthin under nutrient limited cultural conditions. These pigments were subjected for bioassay and noticed that it possessed in vitro free radical scavenging property, cytotoxicity on HeLa and Ht29 cell lines as well as anti-inflammatory property on RAW 264.7 macrophage cell lines by inhibiting the action of inflammatory mediators like COX, LOX, MPO and iNOS and reducing cellular nitrite level. The aplanospores of S. vacuolatus accumulated canthaxanthin, b-carotene, astaxanthin and lutein under Nitrogen-limited conditions in a two-stage cultivation system. These pigments were subjected for bioassay and found that they possessed cytotoxic property on HeLa and HT-29 cell lines. These results indicated the nutraceutical potential of A. quadricellulare and S. vacuolatus.
Our laboratory also conducted diverse study on phytochemicals of plant origin. The plant one which we focused was C. papaya. A preliminary study of the flavonoids of this plant showed that it possessed a variety of nutraceutical potential. Hence, we standardized the methodology for isolating its flavonoid fractions from the leaf further fractionating with HPTLC, identifying flavonoids through UPLC-Q-ToF-MS/MS analysis, quantification by HPLC and evaluating free radical scavenging potential using DPPH and FRAP assays.
The Flavonoid rich fraction and HPTLC separated fractions were characterized via UPLC-Q-ToF-MS/MS analysis and identified 11 flavonoids with 4 new ones. HPLC quantification revealed that mauritianin is one of the major flavonoids in FFCP, with its yield being twofold higher compared to previous reports. Flavonoid rich fraction exhibited significant free radical scavenging and metal-reducing property. The antioxidant activity of the HPTLC fractions of FFCP showed that the quercetin and its derivative-containing fraction (B3) exhibited superior antioxidant activity compared to the fraction containing kaempferol and its derivatives.
The in-vitro investigation demonstrated that the flavonoid fraction of exerts cytoprotective effects on human erythrocytes and peripheral blood mononuclear cells (PBMCs). It was ascertained by SEM, H2O2 induced oxidative damages such as lipid peroxidation, LDH leakage, DNA damages, effectively reduced intracellular ROS production and calcium mobilization. The efficacy was ascertained by increased the activity of antioxidant enzymes, upregulated Nrf2 gene expression and its nuclear translocation. ADMET and drug likeness prediction showed that all flavonoids have good ADME and drug likeness score to develop as a potential drug against oxidative stress associated diseases. Flavonoid rich fraction inhibited the activity of key inflammatory enzymes namely COX, LOX, and iNOS responsible for the production of proinflammatory markers such as prostaglandins, leukotrienes, and nitric oxide. Additionally, the fraction downregulated the expression of the NF-κB transcription factor and the subsequent production of pro-inflammatory markers such as TNF-α, IL-6, and IL-1β in LPS induced cells.
These studies revealing the potential of algal pigments obtained from two algae and flavonoids of plant origin have nutraceutical value to ameliorate the consequences of free radical medicated damages.
Biography
Prof. Krishnakumar. K, PhD in Biochemistry, currently working as a Professor in Department of Botany, Maharaja’s College, supervising research students in the field of nutraceuticals, published more than 25 research articles in the field of nutraceuticals, presented papers in national and international seminars, 25 years of teaching Botany.
Title : The Effect of the Fenugreek Hydrolyzed Protein on Lipid Profile in Patients with Mild-to Moderate Hypercholesterolemia: A Confirmatory Triple-blind Randomized-controlled Clinical Trial
Name : Ali Askari
University : Isfahan University of Medical Sciences
Country : Iran
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The risk of coronary artery disease in people with high serum cholesterol is more than twice as high as in those with moderate serum cholesterol. Natural medicines, especially herbs, have been the focus of attention for many years because of their desirable and minimal side effects for controlling blood lipids. The present study aims to investigate the effect of fenugreek hydrolyzed protein (FHP) on lipid profile. This study is a confirmatory, triple-blind, two-group parallel, randomized controlled trial, phase 3, conducted on patients aged 18–65 years with mild-to-moderate hypercholesterolemia and low risk for cardiovascular disease. Sixty patients were randomized with a 1:1 allocation ratio into the FHP group (N = 30) and the placebo group (N = 30). The intervention group was administrated 40 mg/day of FHP for 8 weeks. The primary outcome was the patient’s lipid profile, including total cholesterol (TC), high- density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), triglyceride (TG), and non-HDL-C. In the intervention group, lipid profile improved through a significant reduction in TC (P < 0.001), LDL- C (P = 0.043), and non-HDL-C (P < 0.001), but no significant changes were observed in the TG level. The mean difference of these variables was -10.07 mg/dl [95 %CI: 30.84; 10.70], -8.93 mg/dl [95 %CI: 27.07; 9.21], and -10.37 mg/dl [95 %CI: 32.26; 11.52], respectively. FHP successfully decreased LDL- C level by 7 % compared to baseline. There was no significant change in any component of the lipid profile in the comparison group. FHP was well tolerated, with only one patient experiencing gastrointestinal adverse manifestations. These findings suggest that FHP administration can improve the lipid profile of patients with mild-to-moderate hypercholesterolemia. Considering the low adverse effects of FHP and patients’ high tolerance, it can be considered in the management of these patients, who fall into the low-risk cardiovascular disease category, adjuvant to the main therapies. Biography
Ali Askari is a medical student at Isfahan University of Medical Sciences. He’s a medical extern with experience as a research assistant in the field of cardiology from 2022 at Isfahan Cardiovascular Research Center.
Title : Exploring Siddha Perspectives in Autoimmune Disorders: Evidence from Crohn’s Clinical Case Studies
Name : Dr. Bhuvanagiri Sathya Sindhuja
University : Chakrasiddh Holistic Healing Centre
Country : India
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Autoimmune diseases, characterized by the immune system’s erroneous attack on the body’s own cells, present a complex pathophysiological challenge, often necessitating a comprehensive and integrative treatment strategy. The current emerging complementary therapies, such as Siddha and energy healing, offer a holistic approach to restoring immune balance by addressing both the underlying causes and symptomatic manifestations of autoimmune disorders. Crohn’s disease (CD), a chronic autoimmune disorder affecting the gastrointestinal tract, is characterized by inflammation, abdominal pain, diarrhea, weight loss, and malabsorption. Conventional treatments involve immunosuppressants, biologics, and surgery, but chances for relapse of the system are always present. Many patients seek complementary therapies to manage symptoms and improve quality of life in such conditions.
According to Siddha principles, Crohn’s is caused by an imbalance in the three humors (Vatham, Pitham, and Kapham), primarily Pitha aggravation, leading to chronic intestinal inflammation. Traditional Siddha medicine offers a holistic and integrative approach in managing Crohn’s disease, focusing on restoring immune balance, reducing inflammation, and healing the gut. This study presents two cases of Crohn’s disease successfully managed at Chakrasiddh, demonstrating significant clinical improvement through Siddha-based therapy, energy healing, and dietary modifications. Both cases exhibited marked improvements in laboratory biomarkers, symptomatic relief, and colonoscopic findings following treatment. Pre and post-therapy assessments, including biochemical parameters, inflammatory markers, and endoscopic evaluations, provide objective evidence of the therapeutic efficacy of this integrative approach. These findings highlight the potential role of Siddha therapies in complementing conventional treatments for autoimmune gastrointestinal disorders like Crohn’s disease, promoting both symptomatic relief and mucosal healing.
Biography
Dr. Sathya Sindhuja, a renowned 36th-generation Siddha healing practitioner, brings over 35 years of expertise in holistic wellness, having successfully treated nearly 100,000 patients worldwide. As the Founder and Director of Chakrasiddh Holistic Centre, she seamlessly integrates Siddha therapies with customized energy healing sessions, fostering profound remedials and balance. Recognized as a divine healer and esteemed astrologer, Dr. Sindhuja possesses the unique ability to read auras, offering insights into both past influences and future well-being. Her exceptional healing practices have garnered international recognition, attracting patients from around the globe. A dedicated philanthropist, she extends free treatments to the underprivileged, exemplifying her unwavering commitment to public welfare and holistic care. She has also served distinguished dignitaries, Telugu celebrities, and prominent personalities, earning widespread admiration. With a specialized focus on women’s health, mind-body interactions, and dietary wellness, Dr. Sindhuja has contributed extensively to the academic and medical communities, authoring 30 peer-reviewed articles and delivering numerous public lectures. Her contributions have been honored with prestigious accolades, including the Times Group’s Icon in Siddha Vaidyam Award and the Dr. A.P.J. Abdul Kalam Award for Ancient Siddha Therapy. Through her compassionate care, groundbreaking research, and holistic healing approach, Dr. Sathya Sindhuja continues to pioneer the global advancement of Siddha medicine, transforming lives and shaping the future of integrative healthcare.
Title : Integrating Somatic Therapy and Bhakti Principles: A Holistic Approach to Trauma
Name : Ashley Amundson
University : Villa Kali Ma - Holistic Treatment Centers for Women
Country : USA
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Trauma healing requires a mind-body-spirit approach, yet traditional mental health treatment often focuses solely on cognitive and behavioral interventions. This presentation explores how somatic therapy, nervous system regulation, and Bhakti principles—rooted in devotion, connection, and emotional surrender—offer a holistic alternative for deep trauma recovery.
Drawing from clinical applications at Villa Kali Ma, this session will showcase how integrating traditional somatic healing methods (breathwork, movement, and polyvagal-informed techniques) with alternative spiritual practices (mantra, self-compassion, and mindfulness) creates a comprehensive healing framework that improves treatment outcomes in both residential and outpatient settings.
Biography
Ashley Amundson, LPCC, LAADC, is a licensed therapist and addiction counselor with a specialization in holistic trauma treatment. As the Director of Operations at Villa Kali Ma, a women’s residential trauma recovery center, she led the integration of somatic therapy, alternative medicine, and clinical interventions to enhance healing outcomes.
With over seven years of experience, Ashley is passionate about bridging traditional and alternative medicine to create a more effective, sustainable model for trauma recovery.
Title : Bio-available Forms of Indian Spices For Enhanced Outcomes to Deliver Benefits Across Human Health—The Emerging Scenario
Name : Suresh Madathycandy Padignareil
University : Spices Board
Country : India
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India is fast becoming an active hub neutraceuticals and is poised to take off to a higher trajectory of growth potential by 2030 reach to a 100 billion dollar industry* from the current growth rate of over 26 percent. It was during the Covid 19 pandemic the growth stabilized from 10 percent to over 16 percent and the shift is still positive. The holistic change was admittedly due to an increase in the wide number of Indians consuming basic nutraceuticals during the pandemic. It was during the pandemic period the Indian community woke up to fuel the growth and touch the present growth from an early meager rate of around ten percent.
It is a fact that the medicinal farming sector is vibrant in its 52 Agro-climatic zones with about 1700 medicinal plants and with the aid of IT applications, the environment is acting as a driving force for raw material supply chain for nutraceutical products. Besides, India has become a focus of vast number of world-class GMP facilities in the Formulation ecosystem and could proudly be termed as having the largest FDA-approved contract manufacturing facilities in the world with additional high-end nutraceutical manufacturing facilities. In fact, India has become a global contract manufacturing hub in nutraceuticals. Further, it is stated that the Start-up ecosystem in India is having around 7500 nutraceutical start-ups embracing latest technological transformation taking place across the entire ecosystem.
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*Survey Conducted by Nutrify Today*
One of the major issues that were currently faced was a lack of awareness among the consumers. The differentiated responsible nutraceutical portfolios need to be drawn up along with clinical validation outcomes. At the current pace and trend, India is likely to offer wealth of opportunities for the nutraceutical industry outside the USA.
From 2021 onwards, Immune health has become synonymous with maintaining a healthy lifestyle. However, except few products related to Black Pepper, Turmeric, Ginger, Fenugreek, Saffron, Pomegranate and few others, there has been a lack of innovation within the Immune Health category. In the wake of a turbulent Covid 2020, consumers are more focused on taking care of their health and are looking for safe, transparent, quality solutions focusing mainly to botanical and herbal solutions.
The emergence of nanotechnology has also changed the face of the booming nutraceuticals in India as well. New technologies like water dispersion technology, The use of Polar-Non-polar Sandwich (PNS) technology, The Hydroalcoholic extraction have also changed the face of nutraceutical industry in India.
New horizons that will contribute to advanced research in the field of Spices primarily leading to have detox potential, strategic nutrition for organ health and holistic health solutions have to be focused upon, including well designed Clinical Studies on a pharma level.
Biography
Dr. M P Suresh is a multi-disciplinary academic post-graduate and Doctoral Degree holder from World-class Madras University, across his career in Spices Board of India, he has handled myriad roles as Editor and Deputy Marketing Director and gained insightful experience in Marketing, Export Promotion, New Product Development, Quality and Safety of spices and spice products spanning over three decades. He gained hands on experience in policy formulation related to marketing, export promotion and export development including market access initiative projects in overseas markets, up-gradation of technology, and organised several National and International Seminars and Buyer-seller meets of Spices Board. Besides a Master trainer and Resource Person for various programmes on marketing and post-harvest improvement of spices, he presented several Papers in National and International Conference, Seminars and Workshops. He had also officiated as Chief Rapporteur in International Conferences including that organised by FAO and WHO.
Suresh has gained rich cross-cultural experience from his travel to Saudi Arabia, Malaysia, Singapore, USA, Brazil, China, Tokyo, UAE and Bahrain.
He has been teaching at prestigious universities like IGNOU, Government of India and Pondicherry University as a Senior Guest Faulty over the last 35 years in multi-disciplinary subjects at Bachelor and Master Level and as a media personnel, he did programmes over Television and also covered national and international events for print media with credit for over 300 articles in leading English publications on a variety of topics. He is a recipient of Fellowship of UNDP.
Title : Evaluation of the Topical Repellent Potential of Essential Oil from Croton sp (Euphorbiaceae) Leaves against Aedes Aegypti (Culicidae)
Name : Janaína Silva de Freitas
University : State University of Southwest Bahia-UESB
Country : Brazil
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Aedes aegypti (Linnaeus, 1762) is one of the most medically important mosquitoes because it is a vector of different arboviruses in urban areas, such as dengue, chikungunya and zika. The use of synthetic topical repellent based on N,N-diethyl-3-methylbenzamide (DEET) is one of the main methods of protection against the vector. However, studies show that mosquitoes have been showing resistance to the repellent action of DEET, which demonstrates the importance of alternative topical repellents, such as those based on essential oils (EOs). Among plant species that synthesize EOs is Croton sp. In this sense, the objective was to evaluate the in vitro topical repellent activity of the EO from Croton sp leaves against Ae. aegypti. For the test, mated female mosquitoes up to ten days old were used. Firstly, we sought to estimate two effective concentrations to repel 50 and 99% of mosquitoes from concentrations of 125; 100; 75; 50 and 25 mg/cm2 formulated in non-ionic emulsion. Each concentration was evaluated as follows: with 50 mosquitoes in the cage, five areas of 4.9 cm2 were marked on the upper part. A quantity of 0.1 g of the formulation initially containing the lowest concentration was applied to one of the markings. Subsequently, an artificial feeder containing 1 mL of blood from Capra aegagrus hircus (Linnaeus, 1758) preheated to 37 °C was placed over each concentration for three minutes (For the use of blood, the project was approved under registration 23076.058811/2020). The evaluation criterion was the number of landings. Next, the protection time of the 99% effective repellent concentration was evaluated. The same materials described above were used for the test. However, the evaluations were as follows: After 30 minutes of applying the 99% effective concentration, the artificial feeder was placed over the concentration for three minutes. Afterwards, the feeder was removed and placed in a water bath until the next evaluation, which occurred at 30-minute intervals, until 360 minutes were completed. The evaluation criteria were landings and blood feeding. The results showed that to repel 50 and 99% of mosquitoes, the estimated concentrations were 3 and 109 mg/cm2, respectively. The concentration of 109 mg/cm2 offered 64.8% protection against landings in 360 minutes and 100% against blood feeding for 150 minutes. The results indicate that Croton sp leaf EO is a promising alternative topical repellent in protection against the mosquito Ae. aegypti.
Biography
Prof. Janaina Freitas holds a degree in Biological Sciences (Licentiate and Bachelor’s) from the State University of Paraíba (UEPB, 2003) and a Ph.D. in Biochemistry from the Ribeirão Preto Medical School – University of São Paulo (FMRP-USP, 2008). Currently is a Full Professor at the State University of Southwest Bahia (UESB), teaching in the Chemistry, Environmental Engineering, Food Engineering, Animal Science, and Biological Sciences programs.
Currently is a permanent member of the Graduate Program in Environmental Sciences (PPGCA) and serves as the Local Coordinator of the Multicenter Program in Biochemistry and Molecular Biology (PMBqBM). Her research focuses on microbial metabolism and genetics, as well as biotechnology, particularly in fermentation processes for bioproduct production. She collaborates with the Innovation and Biotechnology Laboratory (InBiotec).
Title : Effectiveness of Adjuvant Yoga Therapy on Exacerbation Related Adverse Events and Inflammation Among Pediatric Patients with Bronchiectasis: A Pilot Randomized Control Trial
Name : Dr Vyas Kumar Rathaur
University : All India Institute of Medical Sciences
Country : India
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Introduction: Bronchiectasis is a chronic respiratory condition. Pediatric patients with bronchiectasis often experience exacerbations that significantly impact their quality of life and overall health. Conventional treatments primarily focus on managing symptoms and preventing infections, but there is a growing interest in complementary therapies that can enhance these outcomes.
Pediatric bronchiectasis, previously thought to be irreversible and progressive, can actually be halted and even reversed with optimized clinical management. Antibiotics and chest physiotherapy are mainstays for managing bronchiectasis exacerbations. The guidelines by ERS aim to optimize bronchiectasis management by focusing on key aspects such as lung growth, preserved lung function, improved quality of life, reduced exacerbations, minimal complications, and, if feasible, the reversal of lung injury. Yoga has demonstrated positive effects on pulmonary function and quality of life, making it a valuable adjunct therapy. Specifically, yoga practices have been associated with reduced dyspnea-related distress, and enhanced self-reported functional performance in COPD. Respiratory muscle strength training exercises (RMST) are used as a rehabilitation tool or treatment in case of patients with respiratory diseases such as asthma, COPD, respiratory weakness to improve the clinical outcomes. RMST is designed with exercises to enhance strength and endurance of inspiratory and expiratory muscles. Studies show that respiratory muscle training (RMT) interventions improve sputum clearance and respiratory muscle weakness in bronchiectasis.
Aim: The aim of the current trial is to explore the efficacy of yoga based intervention exacerbation related adverse events, inflammatory biomarkers and quality of life among children with BC when compared to the standard care provided at a tertiary care hospital over 6 months.
Objectives- Primary objective:
• Efficacy of yoga-based intervention on frequency of acute exacerbations, hospitalization and need of emergency
medication among children with bronchiectasis over a period of 06 months.
Secondary objective:
● Evaluate quality of life (QoL)
● Lung function assessment
● Inflammatory biomarkers (IL-6, TNF-α)
Materials and methods: –
Study design setting:
Its a two-arm prospective, randomized open labeled blinded endpoint trial with 1:1 allocation ratio. Patients will be randomized into intervention arm and control arm. The study was conducted in collaboration with two departments, i.e. dept. of Pediatric Pulmonary medicine and AYUSH, AIIMS, Rishikesh.
Participants: Patients attending the pediatric medicine and diagnosed case of bronchiectasis were screened for preset inclusion and exclusion criteria.
Description of exposure and follow-up: The intervention group was taught additional yoga practices (as per the protocol enclosed) by institutionally trained yoga therapist over a period of 6 months. Standard medical care were continued for all the patients during the study. There was a minimum of 6 contact classes of 45 minutes each during the study period. The first three supervised sessions were conducted within the first week following the randomization followed by 3 sessions at 3rd month. During the intervention period; i.e. 3 months, the subjects were provided with two online sessions every week. During the noncontact period, the subjects were encouraged and motivated to practice the yoga protocol for 30 min/day daily.
Data Collection: Assessment were taken at 3 points during the study i.e, Baseline, 12 & 24 weeks. And they were encouraged to practice Yoga at home for 6 months. A logbook was maintained by the patient to record the number of home- based practices.
Sample size estimation: There was no study available in the literature in which yoga has been given as an intervention among pediatric BC patients. For the sample size calculation, considering the trial as a pilot explorative trial. 20 subjects in each group is were taken.
Review of literature: Yoga has demonstrated positive effects on pulmonary function and quality of life, making it a valuable adjunct therapy (1,2). Upon practice of Yoga patient’s symptom control and respiratory function values improved and quality of life increased (3). Specifically, yoga practices have been associated with reduced dyspnea-related distress and enhanced self-reported functional performance in COPD (4). Respiratory muscle strength training exercises (RMST) are used as a rehabilitation tool or treatment in the case of patients with respiratory diseases such as asthma, COPD, respiratory weakness to improve clinical outcomes. RMST is designed with exercises to enhance strength and endurance of inspiratory and expiratory muscles (5).
Relevant references in Vancouver style: 1.Yadav A, Singh S, Singh K, Pai P. Effect of yoga regimen on lung functions including diffusion capacity in coronary artery disease patients: A randomized controlled study. Int J Yoga. 2015 Jan;8(1):62–7.
2.Gunjiganvi M, Mathur P, Kumari M, Madan K, Kumar A, Sagar R, et al. Yoga-An Alternative Form of Therapy in
Patients with Blunt Chest Trauma: A Randomized Controlled Trial. World J Surg. 2021 Jul;45(7):2015–26.
Biography
I Dr Vyas Kumar Rathaur is currently working as Assistant professor in the department of pediatrics at one of the most prestigious institute of INDIA, that is AIIMS Rishikesh. I have more than 15 years of post PG research, teaching and clinical experience from various institutes and has more than 50 publications in indexed and pubmed journals.
Title : Exploring Evidence on Path to Workplace Wellness by Harnessing role of Sudarshan Kriya Yoga(SKY)
Name : Dr. Monika Pathania
University : All India Institute of Medical Sciences
Country : India
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SKY is increasingly gaining recognition as a means to relieve occupational stress and burnout especially in high-stress environments. The controlled breathing patterns of SKY are meant to bring about the relaxing effect, emotional regulation, and general improvement in employees’ mental well-being.
Research has shown that SKY can significantly reduce the levels of stress and elevate psychological well-being among professionals. For example, a randomized control trial with medical doctors showed a significant decrease in psychological distress and burnout among participants participating in a SKY program against those who just received standard training on stress management (Korkmaz, 2024). This is specifically relevant because doctors and other professionals in the healthcare line experience high rates of stress and burnout and this can worsen their effectiveness and well-being (Korkmaz, 2024). The study demonstrates the viability of applying SKY as a non-pharmacological intervention in boosting resilience and coping in high-stress occupations.
Additionally, the physiological aspects of SKY contribute to its effectiveness in handling workplace stress. The exercise is known to enhance vagal tone, associated with improved emotional regulation and decreased reactivity to stress (Parimala & Kanchibhotla, 2020; Goldstein et al., 2016). This physiological response is essential for individuals working in stressful work environments, as it may result in effective stress management and reduced anxiety levels (Parimala & Kanchibhotla, 2020). SKY has also been associated with enhanced cognitive functioning and attention, which are necessary for keeping one’s productivity and concentration in the workplace (Chandra et al., 2016; Kopańska et al., 2022).
Besides these, the effectiveness of SKY in reducing burnout is complemented by the fact that it instills a feeling of community and social support in practitioners. Practice in group sessions of SKY can enhance the sense of social connection, a protective factor for burnout, as indicated by Vasudev et al. (2022). This sense of community provides both emotional support and stimulates the sharing of coping strategies at work, therefore creating a work environment that fosters support.
There is a potential positive effect of integrating SKY into workplace wellness programs. Organizations that adopt SKY as part of their employee wellness initiatives have reported improvement in employee satisfaction, reduced absenteeism, and overall workplace morale (Bhaskar et al., 2020). These outcomes suggest the potential for SKY as a holistic approach to managing workplace stress and preventing burnout.
In conclusion, Sudarshan Kriya Yoga offers a multifaceted approach to addressing workplace stress and burnout. Its effectiveness in reducing psychological distress, enhancing emotional regulation, and fostering social support makes it a valuable intervention for individuals in high-stress occupations. Continued research and implementation of SKY in workplace settings could provide significant benefits for employee well-being and organizational health.
Biography
Dr. Monika Pathania is an accomplished medical professional serving as an Additional Professor in the Department of Medicine at the All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand. She has also held key administrative roles as Ex-Associate Dean (Research) and Ex-Assistant Dean (Student Welfare) at the institute. With a distinguished academic background, including an MD in Internal Medicine and certifications in Lifestyle Medicine (IBLM, ASLM, ISLM), Dr. Pathania has significantly contributed to healthcare innovation. She pioneered the institute’s first “Lifestyle Disease Clinic” and later expanded it into an Integrative Medicine Clinic and a Professional Burnout and Well-Being Clinic. Her research portfolio includes 112 publications and 18 projects. She is a DFID fellow in diabetes from CMC Vellore and a board-certified lifestyle medicine physician. Additionally, she is a certified yoga instructor under AYUSH (200 hours) and SSY. Dr. Pathania’s excellence has been recognized with several prestigious awards, including the Outstanding Woman Researcher in Internal Medicine Award (VIWA 2024), Excellence in Research of the Year Award (DISTF-2023), and Best Teacher Award (2018). She has also received accolades for her presentations at national conferences and achievements in yoga competitions.
Title : Hydrogels in Drug Delivery: Revolutionizing Therapeutic Precision through Smart, Tunable System
Name : Saruchi
University : St. Solider group of Institutions
Country : India
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Hydrogels, characterized by their three-dimensional crosslinked polymeric structure and remarkable water retention capability, have become a cornerstone in the development of advanced drug delivery systems. These materials exhibit unique physicochemical properties, including high porosity, biocompatibility and tunable mechanical strength, which make them ideal candidates for delivering a broad spectrum of therapeutic agents. The water content of hydrogels, which can exceed 90%, not only provides an aqueous environment conducive to the stabilization of hydrophilic drugs but also mimics biological tissues, enhancing their potential for in vivo applications. One of the most compelling advantages of hydrogels in drug delivery lies in their tunability. Through careful modification of their polymer composition, crosslinking density and degradation profile, hydrogels can be engineered to achieve controlled, sustained, or pulsatile release of drugs over prolonged periods. This adaptability enables the formulation of
personalized treatments, especially for chronic conditions requiring consistent drug dosing, such as diabetes, cancer, and cardiovascular diseases. Furthermore, hydrogels can be designed to respond to external or internal stimuli—such as changes in pH, temperature, light, or the presence of specific enzymes—allowing for smart, site-specific drug delivery. For example, pH-sensitive hydrogels are advantageous for delivering drugs to acidic
environments, such as tumor tissues, ensuring targeted release and reducing systemic side effects. Recent advances in hydrogel technology have led to the development of sophisticated systems that integrate nanotechnology and bioengineering. Nanocomposite hydrogels, which incorporate nanoparticles, nanofibers, or nanocapsules, offer enhanced mechanical properties and multifunctionality. These systems can encapsulate drugs within nanocarriers that provide additional control over release rates, improve drug solubility, or protect drugs from premature
degradation. Similarly, injectable hydrogels have gained significant attention for their minimally invasive application. These hydrogels can be administered through simple injection, where they gel in situ upon exposure to physiological conditions, making them ideal for localized drug delivery in tissue repair and regenerative medicine. Another area of innovation is the use of hydrogels for the delivery of biologically active molecules, such as proteins, peptides, and nucleic acids, which are highly sensitive to degradation. Hydrogels provide a protective matrix that preserves the bioactivity of these molecules, facilitating their controlled release and improving therapeutic efficacy. This has broad implications for gene therapy, immunotherapy, and the treatment of complex diseases, where precise dosing and controlled spatial and temporal release are critical. In conclusion, hydrogels represent a transformative platform in drug delivery, offering unparalleled versatility, biocompatibility, and functionality. Their ability to provide controlled, localized, and responsive drug release, coupled with recent advancements in nanotechnology and biomaterials, positions them as key players in the next generation of therapeutic delivery systems. Hydrogels are poised to revolutionize the treatment of diseases across multiple fields, from cancer and chronic illnesses to regenerative medicine, offering promising avenues for personalized and precision medicine.
Keywords: Hydrogels, Medicine, Nanotechnology, Drugs and Environment.
Title : Current Innovative Approaches in Reducing Carcinogenic Polycyclic Aromatic Hydrocarbons (PAHs) in Indian Environment by Different Technique
Name : Vaneet Kumar
University : CT Group of Institutions
Country : India
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Different thermo-processing methods, including smoking, grilling, barbecuing, roasting, and frying, which use heated fuels and unusually high temperatures, produce PAHs in our environment. The production of these extremely hazardous and persistent carbonaceous compounds with two or more cyclic benzene rings is facilitated by poor thermal processing methods, tainted raw materials, and environmental contamination. To avoid safety and public health hazards, it is vital to concentrate on the prevention and control of PAH development in the environment using a variety of techniques. In order to prevent or lessen the negative effects of PAHs, a number of strategies have been employed, including the employment of biological procedures, safe processing systems, innocuous cooking techniques, marinating with natural plant components, etc. In this paper we will discuss reduction of PAHs from our environment by different blending technique, green diesel technique, photochemical and bioremediation methods.
Keywords: Petrodiesel Engine; Green Diesel; Biodiesel; Carcinogenic PAHs; photochemical.
Title : Mindfulness in Medicine: Promoting Health, Well-Being, and Resilience
Name : Dr. Anju Sawni
University : Michigan State University
Country : USA
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Background: Resident physician burnout is a long-standing issue in medical education with the COVID-19 pandemic causing significant additional burnout burden. Navines et. al. (2021) found current burnout rates of residents as high as 76% (vs 50% prior). Implementation of mindfulness programs has been shown to improve physician wellness, decrease burnout, & create environments of resilience (Romcevich et.al 2018, Ireland,et. al 2017). Epstein et. al. (2021) implemented a 4-day mindfulness workshop for physicians, improving emotional exhaustion, depersonalization, & patient-centered care. While mindfulness has recently come to the forefront of wellness, few studies describe feasible, longitudinal programs focused on resident wellness. Programs like Search Inside Yourself (SIY) teach mindfulness, emotional intelligence & leadership skills & may assist with mitigating burnout.
Objective: To assess a feasible, longitudinal mindfulness program (SIY) for resident physicians to combat burnout & stress; build resilience; & improve self-care.
Design/Methods: After completion of SIY training, Dr. Sawni (pediatrician) & Dr. Wolf (psychologist), taught a modified version to Pediatric & Medicine-Pediatric residents at Hurley Hospital, Flint MI. It consisted of 12 hours, split over 3 consecutive sessions. Pre & post-surveys were given,(n=25) assessing demographics, wellness, & program evaluation. Desired responses to 29 wellness questions (combining Strongly Agree/Agree, Very Often/Often, Strongly Disagree/Disagree, or Rarely/Never) were compared pre- to post-training. The study was approved by Hurley Hospital IRB.
Results: Of the 29 wellness questions,10 items had a positive change by at least 10 percentage points. There were 5 items, related to distractibility, that decreased by at least 10 points, indicating that mindfulness helps with being more present. After the program, 93% of attendees said they were Satisfied/Very Satisfied with the mindfulness program and 93% agreed that the material was relevant to current challenges. The majority (86%) reported feeling ready to apply what they learned.
Conclusions: Mindfulness as an approach to mitigate burnout & stress has been successful with resident physicians in limited previous studies. Teaching & incorporating mindfulness is feasible & can be introduced as part of the core residency curriculum. This pilot study presents a feasible way to incorporate mindfulness training within the educational context. Though the number of completed surveys was relatively low, the overall impact of the study was large. Limitations include a small sample size & a limited number of sessions. Future programs will include similar mindfulness interventions to support wellness longitudinally.
Biography
Dr. Anju Sawni M.D. FAAP, FSAHM is the Director of Adolescent Medicine at Hurley Children’s Hospital/Hurley Medical Center, Flint MI & Associate Professor of Pediatrics Department of Pediatrics & Human Development, Michigan State University/College of Human Medicine, Lansing, MI. Her interest not only includes Adolescent Health, but also Integrative Medicine. She is a member of the AAP section on integrative pediatrics. She has done research, published several papers & written chapters on Adolescent health & Integrative Medicine, and presented many lectures/workshops; nationally, statewide & locally. She integrates mind/body therapies such as relaxation techniques/self-hypnosis/mindfulness meditation, yoga, nutritional supplements, etc. in her adolescent practice. She has trained in mindfulness with Dr. Ronald Epstein, the University of Rochester, Mindfulness in Medicine Program, Search Inside Yourself Institute that promotes Mindfulness, Emotional Intelligence & Leadership & Awake Network; mindful health care summit as well as given several lectures on “Mindfulness in Medicine”. She incorporates/teaches mindfulness in medicine as part of the professionalism series to Hurley hospital & McLaren Health system residents. She serves on the board of directors of the Crim Foundation Mindfulness Initiative, Flint MI. She practices meditation/mindfulness/yoga in her personal and professional life.
Title : Effect of Anuloma Viloma Pranayama (AVP) on Heart Rate Variability (HRV) and Brain Activity: A Cohort Study
Name : Dr. Varun Malhotra
University : All India Institute of Medical Sciences
Country : India
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Anuloma Viloma Pranayama (AVP), also known as Alternate Nostril Breathing (ANB), is a widely practiced pranayama technique known for its regulatory effects on cardiovascular and brain activity. This study aimed to explore the simultaneous effects of AVP on heart rate variability (HRV) and brain wave activity in a cohort of 30 healthy volunteers practicing kriya yoga for over 15 years. The study was conducted from October to December 2021. ECG for HRV analysis and EEG recordings for brain wave spectrum analysis were collected during three phases: pre-AVP, during AVP, and post-AVP, each lasting five minutes.
Statistical analysis using repeated measures of analysis of variance (ANOVA) with Bonferroni and Holm’s post-hoc comparisons showed significant increases in time-domain HRV parameters (SDNN and RMSSD) during AVP compared to pre- and post-AVP. In frequency-domain analysis, total power, LF power, HF power, and LF/HF ratio also showed significant increases during AVP, with the LF/HF ratio remaining elevated post-AVP. EEG recordings revealed a significant rise in Alpha, Beta, and Gamma wave power during AVP compared to baseline and post-AVP phases. These findings suggest that the lungs, heart, and brain act as coupled oscillators, and AVP induces an aroused, attentive state without significantly affecting heart rate, while enhancing overall HRV.
Biography
Dr. Varun, MD, DNB, MNAMS, holds a diploma in Naturopathy and Yoga and has been a regular faculty member at several institutions. He previously served as a Professor and Head of the Department at Santosh Medical College and is currently an Additional Professor in the Department of Physiology at AIIMS Bhopal. With 22 years of experience, his research interests include Medical Education and Mind-Body Medicine. Dr. Varun conducts yoga and meditation sessions for students and staff and enjoys sharing his passion for physiology. He has received multiple awards, including the prestigious Shri Ram Murthy, VIHA, and ISSN awards.
Title : Current Concepts in the Management of Neuropathic Pain
Name : May L. Chin
University : George Washington University
Country : USA
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Unrelenting neuropathic pain presents challenges in diagnoses and treatment. The International Association for the Study of Pain (IASP) defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory nervous system.” The injury or disease may occur in the peripheral or central nervous system giving rise to painful conditions such as post herpetic neuralgia, painful diabetic neuropathy, post amputation pain, complex regional pain syndrome, trigeminal neuralgia, post stroke pain, and pain after spinal cord injury, to name a few. These patients are frequently disabled from severe pain, have poor quality of life, and suffer from anxiety, depression and sleep problems. They often strain the healthcare system with frequent visits. Treatment of neuropathic pain can be challenging, often exhausting conventional approaches. A multimodal approach integrating pharmacological, interventional and integrative modalities may be helpful. This talk will cover a brief review on the pathophysiology of pain and focus on interventions that specifically target neuropathic pain, such as neuromodulation, including peripheral nerve stimulation and infusions using ketamine.
Biography
Dr. Chin is Professor Emeritus of Anesthesiology and Critical Care Medicine at the George Washington (GW) University, Washington DC. She served as Director of the GW Pain Medicine Fellowship Program and Co Director of the GW Spine and Pain Center. Dr. Chin earned her medical degree at the University of Melbourne, Australia. Her interests include innovative pharmacological, interventional and neuromodulatory techniques for management of chronic neuropathic pain. She has published on topics in pain medicine including pain in women, written numerous articles and authored book chapters on both acute and chronic pain. She served on the American Society of Anesthesiologists (ASA) Pain Medicine Committee, the American Medical Association (AMA) advisory board for pain, the Anesthesia and Analgesia (A&A) Editorial board as a reviewer, and the American Board of Anesthesiologists (ABA) as an associate board examiner. She has presented and lectured on acute and chronic pain at national meetings including the ASA, the American Society of Regional Anesthesia and Pain Medicine and the American Academy of Pain Medicine. For the past twenty years she was consistently listed in Washington Top Docs for Pain Medicine and was recently awarded the Trailblazer Award from ASRA.