Title : Comparison of Mean Platelet Component and Mean Platelet Mass in Immune Thrombocytopenia Versus Hypoproductive Thrombocytopenias
Name : Mala Varma
University : Mount Sinai Health System
Country : USA
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Introduction: The Siemens (Bayer) ADVIA 120 has the capacity to calculate the mean platelet component (MPC), a measure of platelet density, and the mean platelet mass (MPM). In September 2013, we initiated a prospective study to determine if the MPC and MPM are significantly higher in immune thrombocytopenia than in hypoproductive thrombocytopenias. Methods: Lavender tri-potassium EDTA tubes were filled and analyzed on the Siemens (Bayer) ADVIA 120 within a period not exceeding two hours from their collection. The student’s t-test was used to compare these parameters in the patient groups. Coefficients of variation were used to study intra-individual variability and inter-individual variability. Results:Twenty patients with immune thrombocytopenia and 20 patients with hypoproductive thrombocytopenias were enrolled. The MPC and MPM were significantly higher in immune thrombocytopenia than in hypoproductive thrombocytopenias. A unique patient was studied when he had immune thrombocytopenia and then when he had chemotherapy-induced thrombocytopenia during treatment of lymphoma. His MPC and MPM were significantly higher during immune thrombocytopenia than during chemotherapy-induced thrombocytopenia. Intra-individual variability and inter-individual variability were low in this study. Conclusion: A strength of our study is that the MPC and MPM assays were measured within 2 hours of collection, since the MPC decreases over time. Our results attest to the clinical utility of MPC and MPM toward distinguishing immune thrombocytopenia from hypoproductive thrombocytopenias.
Biography:
Dr. Mala Varma is an Assistant Clinical Professor of Medicine at the Icahn School of Medicine at Mount Sinai, New York, USA. She has research interests in platelet and coagulation disorders. She has developed original studies for the treatment of immune thrombocytopenia and immune thrombotic thrombocytopenic purpura with danazol: Varma M, Shapira I, Friedman M, Nakhoul I, Torri V, Shulman J, Kozuch P, Culliney B, Patel AA, Yoe J, Shah VP, Mirzoyev T, Machuca M. Danazol and cost-savings in immune thrombocytopenia and in immune thrombotic thrombocytopenic purpura. Blood Coagul Fibrinolysis. 2025 Dec 1;36(8):388-390.
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